Week 3 Neuro Flashcards

1
Q

In peds, must r/o these severe head injury before dx of minor head injury or mild TBI (concussion):

A
  • skull fracture
  • spinal cord injury
  • brain bleeds
  • moderate-severe TBI
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2
Q

What guideline is used if a CT scan is needed?

A

PECARN calculator

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3
Q

Glasgow coma scale score 13-15 means

A
  • mild
  • no focal deficits
  • < 30 minutes LOC
  • may have linear skull fractures
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4
Q

Glasgow coma scale score 9-12 means

A
  • moderate
  • focal signs
  • variable loss LOC
  • may have depressed skull fracture or intracranial hematoma
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5
Q

Glasgow coma scale of < 8 means

A
  • severe
  • focal signs
  • prolonged loss LOC
  • depressed skull fractures and intracranial hematoma
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6
Q

Pedi head injury management

A
  • If worried caregiver is not reliable = admit
  • Discharge home with close observation:
    • Minor head trauma and no LOC
    • Brief LOC (< 5 mins) with:
      • Normal neuro exam
      • No s/sx IICP (vomiting, h/a)
      • No s/s basilar skull fracture (raccoon eyes, battle sign)
    • With or w/o a head CT
  • Wake child every 2-4 hours at night for first 24-48 hrs
  • Educating parent s/sx of deterioration
    • Not responding to q’s
    • Vomiting
    • Horrible headache
    • Slurring speech
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7
Q

highest risk sport for boys and girls for concussion/mild traumatic brain injury?

A

boys: football and hockey
girls: soccer and basketball

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8
Q

concussion red flags, bring to ED!

A
  • Weakness, numbness, decreased coordination
  • Worsening headaches
  • Repeated vomiting or nausea
  • Slurred speech
  • Anisocoria (unequal pupils)
  • Seizures
  • very drowsy
  • Increasing confusion, agitation, restlessness
  • Focal neurological signs
    • Problem with nerve, spinal cord, left side face numb / arm numb, paralysis of leg
  • Can’t recognize people or places
  • Neck pain
  • Unusual behavior changes
  • Any loss of consciousness, especially if for 30 seconds or more
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9
Q

retrograde amnesia vs anterograde amnesia

A

retrograde amnesia: very brief, can’t recall events before injury

anterograde amnesia: seconds-minutes, can’t make new memories and can’t recall

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10
Q

which imaging preferred for concussions? and what are the indications?

A

CT scan

indications:

  • Focal neurological findings
  • Signs of IICP
  • GCS < 15 after 2 hrs OR < 13 at any time
  • Seizures r/t to trauma
  • Age > 60
  • Anticoagulation or coagulopathy
  • Intoxication
  • Recurrent vomiting
  • s/sx skull fracture
  • LOC (excessive irritability or lethargy)
  • LOC >1 min
  • Amnesia
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11
Q

simple concussion

A

sx’s resolve (brain healed) in 7-10 days without complications

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12
Q

complex concussion

A
  • prolonged healing that is persistent for over 10 days
  • may develop post concussive syndrome
  • prolonged impaired cognitive function
  • repeated concussions
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13
Q

concussion monitoring

A

repeat neuro exam q 15 mins

if sent home, monitor next 24 hrs:

  • Inc drowsiness
  • Vomiting > 2x
  • Neck pain
  • Drainage from ear / nose
  • Seizure , fainting
  • Unu irritability, personality changes
  • h/a getting worse or lasts > 1 day
  • Unequal pupils, blurred vision
  • Gait abnormalities
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14
Q

When can the child return to play after a concussion?

A

not until all symptoms have cleared, both at rest and with exertion and without meds

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15
Q

Return to play guidelines after a concussion

A
  • Physical & cognitive rest for the first 24-48 hrs before return to play, 24 hrs or longer each step
  • Need to communicate with coach, teachers
  • Advance activity slowly (includes screen use, reading, homework, physical activity) with lots of breaks
    • 1 - sx limited activity (no sx)
    • 2 - light aerobic - no weights
    • 3 - sport specific
    • 4 - non contacting drills - yes weights
    • 5 - full contact practice
    • 6 - return to play
  • If symptoms return, cannot attempt that activity again for 24 hours
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16
Q

concussion prevention

A
  • Wear helmets when appropriate and properly fitted
  • Avoid re-injury before first concussion resolves
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17
Q

What is second impact syndrome?

A
  • Patient sustains a 2nd head injury before the symptoms from the first head injury have resolved
  • Days to weeks after the first injury
  • LOC is not a requirement; impact may be mild and athlete may appear only dazed initially
  • Can cause cerebral edema and herniation, leading to death

*Stress importance with patients that ALL concussion symptoms must be resolved prior to return to activity*

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18
Q

What is post concussive syndrome?

A
  • Sequela of minor head injury
  • poorly understood
  • at least 3 of these:
    • h/a, dizziness, fatigue, irritability, impaired memory/concentration, insomnia, lowered tolerance for noise and lights
  • no imaging needed unless red flags
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19
Q

What is Bell’s palsy?

A
  • Acute, isolated peripheral facial paralysis of the 7th cranial nerve
  • most common cause: HSV activation
    • Other associated viruses are: cytomegalovirus, Epstein–Barr virus, adenovirus, rubella virus, influenza B, coxsackie virus
    • Pregnancy
  • most spontaneously resolve
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20
Q

What is Bell’s palsy?

A
  • Acute, isolated unilateral peripheral facial paralysis of the 7th cranial nerve
  • most common cause: HSV activation
    • Other associated viruses are: cytomegalovirus, Epstein–Barr virus, adenovirus, rubella virus, influenza B, coxsackie virus
    • Pregnancy
  • most spontaneously resolve
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21
Q

Bell’s palsy sx’s

A
  • Sx’s can persist up to 3 months
  • Acute onset (w/in 48 hrs) of unilateral of upper and lower facial paralysis
  • Weakness of facial muscles
    • flattening of the nasolabial fold
    • drooping mouth/asymmetrical smile
  • Hyperacusis (sounds too loud)
  • Posterior auricular pain
  • Decreased tearing
  • can’t close eyelid = irritation
  • Taste disturbances
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21
Q

Bell’s palsy sx’s

A
  • Acute onset (w/in 48 hrs) of unilateral of upper and lower facial paralysis
  • Weakness of facial muscles (flattening of the nasolabial fold and drooping of the affected corner of the mouth)
  • Hyperacusis (sounds too loud)
  • Posterior auricular pain
  • Decreased tearing
  • Poor eyelid closure
  • Taste disturbances
  • Otalgia
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22
Q

when are you worried if it’s a central cause/stroke or if it’s Bell’s palsy?

A

a stroke/central cause would have only 1 area affected (mouth drooping) and other parts of face are still movable like wrinkling forehead and eyes

paralysis from stroke spares forehead

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23
Q

What grading system used for Bell’s palsy?

A

house and brackmann system

1 = normal

6 = severe paralysis

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24
Q

bells palsy diagnostic criteria

A

paralysis or paresis of *all* facial nerve muscle groups unilaterally, sudden onset and absence of CNS disease

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25
Q

What other testing to consider in dx for Bell’s Palsy?

A
Lyme titer (if tick exposure)
MRI (if don't recover in 3 months)
EEG/EMG (if fail to improve)
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26
Q

Bell Palsy treatment/management

A
  • Corticosteriods/Prednisone w/in 72 hrs of sx onset
  • or Acyclovir or valacyclovir in conjunction
  • Eye care
    • risk for corneal abrasions/ ulcers
      • Artificial tears during the day and lubricating ointment at night
  • tape or an eye patch for 24–48 hours to help heal a corneal abrasion
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27
Q

Ramsay hunt syndrome

A
  • Peripheral facial nerve weakness caused by varicella zoster
  • Same symptoms as Bell’s palsy but:
    • rash/vesicles
    • Paralysis more severe
    • Anterior tongue numbness, ear pain, vertigo, hearing impairment
    • Less likely to have a complete recover

Treat early with oral glucocorticoids and antivirals:

  • Prednisone and acyclovir
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28
Q

what is the SCAT5?

A

sport concussion assessment tool 5

  • No screen time, no reading, no strenuous activity
  • No aspirin or NSAIDs
  • Worsening sx’s to seek help
  • Enough rest /sleep
  • Return in 7-10 days and repeat SCAT test to see
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29
Q

Is imaging indicated with recurring, stable headache with normal neurological exam?

A

NO

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30
Q

indications for imaging for headache include

A
  • Abnormal neuro exam findings
  • History suggestive of ICP
  • seizures
  • Recent onset of severe HA
  • Change in type or pattern of HA
  • Severe HA with underlying disease that predisposes them to intracranial process (sickle cell anemia, HTN, coagulopathy, history of neoplasm, neurofibromatosis
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31
Q

what is SNOOP and what is it for?

A

headache warning signs

  • systemic symptoms
    • fever, muscle pain, weightless
  • neoplasm or neurologic sx’s
  • onset
    • How fast h/a sets in, severely
  • older age
    • 50+
  • pattern, position change, pregnancy, progressive, painful eye
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32
Q

tension headache sx’s

A

at least 2 of:

  • bilateral, band like
  • pressing/tighening quality
  • mild to moderate intensity
  • no aggravation from routine physical activity

both of these:

  • NO n/v
  • NO photophobia or photophobia
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32
Q

tension headache sx’s

A

at least 2 of:

  • bilateral, band like
  • pressing/tighening quality
  • mild to moderate intensity
  • no aggravation from routine physical activity

both of these:

  • NO n/v
  • NO photophobia or photophobia
33
Q

tension headache treatment

A
  • Tylenol, asa, NSAIDS (ibuprofen, naproxen); caffeine [don’t overuse]
  • Consider prophylaxis if headaches are frequent (>2/ week), of long duration (> 3-4 hours), or severe enough to cause significant disability or overuse of abortive treatment
    • Amitriptyline only proven medication
34
Q

what medications are NOT helpful with tension headaches?

A

triptans

barbiturates, opiates

35
Q

do the majority of migraines have aura or no aura?

A

80-85% have no aura

15-20% have aura (positive sx’s: flashing lights, scintillation, paresthesia then neg sx’s numbness, aphasia, scotoma (chunk of vision gone))

36
Q

migraine triggers

A
  • Changes in weather (heat, humidity, high altitude)
  • Stress; crying
  • Alcohol
  • Hunger
  • Fatigue / no sleep
  • Loud noises
  • Flickering lights
  • Noxious stimuli
  • Foods
    • Fried food, red wine, hot dogs (MSG), cheese, chocolate, cured meats & fishes, peanuts
  • Exertion
  • Nitroglycerin
  • Minor head trauma
  • Menses
  • Surgical menopause
37
Q

migraine diagnosis

A

repeated attacks lasting 4-72 hrs, normal exam and no other reasonable cause for headache

at least 2:

  • unilateral pain 60%
  • throbbing/pulsating pain
  • aggravating of movement or activity
  • mod-severe

at least 1:

  • nausea/vomiting
  • photophobia or photophobia
38
Q

How to treat migraines?

A
  • avoid triggers
  • headache diary
  • educate: won’t cure but will try controlling
  • abortive treatment and preventative treatment
39
Q

Migraine preventative treatment indications

A
  • > 4 attacks a month
  • Consider comorbid conditions when prescribing medications
  • Freq long lasting h/a a/s with significant disability
  • Contraindication to abortive tx
  • Frequ use of abortive tx
  • Uncommon migraine (hemiplegic, basilar, migraine with prolonged aura, migrainous infarction)
40
Q

migraine preventative treatment

A
  • Start low, titrate up for 8–12 weeks (educate results til 8 weeks)
  • TAPER OFF if need to d/c!
    • Beta blockers [propranolol]
    • TCAs [Amitriptyline]
    • Valproate [BBW suicide]
    • Topiramate
    • CCB [verapamil]
  • CGRP (monoclonal antibody): a potent vasodilator
    • ‘numab’ = monoc. antib
      • Erenumab (Aimovig)
      • Fremanezumab (Ajovy)
      • Galcanezumab (Emgality)
      • Eptinezumab (Vyepti): IV
41
Q

Migraine abortive treatment

A
  • start ASAP when it comes
  • limit abortive use max 2 days per week (rebound analgesic)

mild to moderate: Tylenol, NSAID, allieve, excedrin, triptans

severe (incapacitating; ED): abortive + IV/IM antiemetics (metoclopramide, Benadryl)

42
Q

pediatric red flags headaches

A
  • < 5- 6 yrs old
  • New onset
  • Focal neuro signs
  • Nocturnal awakening [Tumor]
  • Vomiting, papilledema [IICP]
  • Loss of cognitive/neuro functioning
  • Sig change in existing h/a pattern
  • Head trauma with LOC >10 minutes
  • Inability to control headache with appropriate tx
43
Q

Pediatrics: migraine abortive vs preventative treatment

A
  • abortive: early as possible, NSAIDs more effective, sleep, sedative if distressed (dephenhydramine/benzos)
  • preventative: NOT recommended but mostly lifestyle, propranolol, topiramate
44
Q

pediatrics tension headache

A

mild - analgesics

refer if more severe (analgesics, indomethacin (not for young), combo)

45
Q

define seizure and epilepsy

A

seizure: abnormal focal or generalized neuronal discharge with physical manifestations
epilepsy: 2 or more unprovoked seizures

46
Q

most common secondary identifiable cause of seizures in adults and children?

A

adults: stroke, vascular disease, neurocysticercosis (tapeworm in brain)
children: idiopathic

47
Q

causes of seizures in neonates (< 1 month)

A
  • Perinatal hypoxia and ischemia
  • Intracranial hemorrhage and trauma
  • Acute CNS infection
  • Metabolic disturbances (hypoglycemia, hypocalcemia, hypomagnesemia)
  • Drug withdrawal
  • Developmental disorders
  • Genetic disorder
48
Q

causes of seizures: infant and children (1 month - 12 yrs)

A
  • Febrile seizures
  • CNS infection
  • Trauma
  • Genetic disorders (metabolic, degenerative, primary epilepsy syndromes)
  • Idiopathic
49
Q

causes of seizures in adolescents (12-18 yrs)

A
  • Trauma
  • Genetic disorders
  • Infection
  • Brain tumor
  • Illicit drug use
  • Idiopathic
50
Q

causes of seizures in young adults

A
  • Trauma
  • Alcohol withdrawal
  • Illicit drug use
  • Brain tumor
  • Idiopathic
51
Q

causes of seizures in older adults > 35 yrs

A
  • Cerebrovascular disease (embolic stroke, hemorrhagic, thrombotic stroke)
  • Brain tumor
  • Alcohol withdrawal
  • Metabolic disorders (hepatic failure, hypoglycemia, uremia, hyponatremia)
  • Idiopathic
52
Q

generalized tonic clonic/grand Mal seizure

A
  • most dramatic and most common generalized epilepsy
  • May begin as a cry as the result of air moving across the glottis from sudden tonic muscle contraction
  • Tonic phase: stiffening of limbs bilaterally
  • Clonic phase: rhythmic jerking, will become slower in frequency as seizure is coming to an end
53
Q

absence seizures/petit mal seizure

A
  • Momentary loss of awareness
  • May not realize the seizure has occurred
  • Few seconds
  • NO post-ictal period
  • Typically begin in childhood, often noticed first by school teachers
  • Misdiagnosed with ADHD
54
Q

myoclonic seizures

A
  • Brief episodes of sudden motor contraction, often flexion of the upper extremities; muscle jerks
  • difficult to tell if LOC occurs or not
  • Most commonly occur in the morning just after awakening, or when awakening from a nap
55
Q

atonic seizures

A
  • drop attacks
  • Brief episodes that are characterized by a sudden increase or decrease in muscle tone
  • dramatic falls
  • Wear protective head gear
56
Q

simple partial seizures

A

simple partial: sensory complaints: metallic taste in mouth, rising sensation in stomach, déjà vu

  • Others are generally unaware the patient is having a seizure unless the patient tells someone
  • Gelastic seizures: bursts of uncontrollable laughter not associated with anything funny, typically only seen with hypothalamic hamartomas (rare)
57
Q

complex partial seizures

A
  • may seem alert and responsive, but patient is not aware of what is going on
  • can talk but doesn’t make sense
  • May have automatisms [non purposeful movements (picking at clothing, lip smacking, nose wiping)]
58
Q

non epileptic seizures/psychogenic seizures

A
  • Paroxysmal events that have NO electrographic correlate
  • Very similar to true epileptic seizures
  • Patients are NOT faking; they are unaware these are not true ictal events
  • Often associated with psychiatric disorders such as depression, anxiety, borderline personality disorder, OCD, PTSD
  • Hx of physical, emotional or sexual abuse
  • May have both epileptic and non-epileptic seizures
  • Diagnosis: Capture an event on video
    • EEG monitoring
59
Q

Epileptic seizure (vs Non ES)

A
  • LOC with generalized motor activity
  • Eyes are generally open
  • Mouth generally open
  • Tongue bite on the lateral edges
    • Tongue falls when on side
  • No response to painful stimuli
    • Sternal rub to test
  • Episode is short-lived (< 5 minutes)
60
Q

Non epileptic seizures (vs ES)

A
  • Awake, alert
  • Forced eye closure
  • Forced mouth closure
  • Tongue bite on the tip of the tongue
  • Normal response with painful stimuli
  • Episode can wax and wane for hours
61
Q

seizure (vs syncope)

A
  • LOC quick
  • Can have cyanosis
  • motor manifestations lasting >30 seconds
  • post-ictal disorientation, muscle soreness, and sleepiness
  • Accompanied by an aura
  • Duration of tonic-clonic movements is usually 30–60 seconds
    • TIME!
  • Tongue biting, incontinence, and post-ictal headache
62
Q

syncope (vs seizure)

A
  • Provoked by acute pain, anxiety, or occurred immediately after rising from a lying or sitting position
  • Stereotyped transition to unconsciousness that includes tiredness, sweating, nausea, and tunnel vision
  • Can have convulsive movements if remains upright after losing consciousness due to sustained decreased cerebral perfusion (such as in a dentist chair)
  • may have incontinence
  • Tonic-clonic movements < 15 seconds
  • Rarely see tongue biting or post-event headache; can have incontinence (not common)
63
Q

treatment for seizures

A
  • 1st line: anti epileptic medications
  • surgery: implantable devices
63
Q

treatment for epilepsy

A
  • start med after 2nd seizure
    • 1st line: anti epileptic medications
    • don’t sub to generic brand (dilantin and phenytoin)
  • surgery
    • temporal lobectomy
    • lesionectomy
    • multiple subpial transection
    • corpus callosotomy
    • hemispherectomy
  • implantable devices
    • vagal nerve stimulator (under clavicle)
    • NeuroPace (pacemaker for brain)
    • Deep brain stimulator
64
Q

hormonal birth control and AED meds

A
  • Counsel oral contraceptives will be less effective and they may need to use a back-up method
    • phenytoin, phenobarbital, carbamazepine, topiramate, oxcarbazepine, and lamotrigine
      • Lamotrigine makes BC less effective and BC makes lamotrigine less effective
  • need at least 50 mcg of estrogen to overcome interaction (use backup)
  • Efficacy of the morning-after pill is decreased
    • Interaction with BC hormones (NuvaRing, Mirena, etc.)
  • Folate should be prescribed in all women of childbearing age taking AEDs.
    • Tegretol reduces folate in body
  • AEDs OK in pregnancy
    • risk of tonic-clonic seizure during pregnancy greatly outweighs fetal risk
  • Valproic acid considered the most teratogenic of all the AED
    • 10% risk of congenital malformation (cleft lip and cleft palate)
65
Q

childhood absence epilepsy

A
  • Girls 60–78%
  • Peak: 6-7 years years old
  • Tend to occur in developmentally normal children
  • seizures are brief, often lasting 5–10 seconds; they start and stop suddenly
  • NOOO post-ictal period
  • 10–100x/day
  • May also see eye fluttering, eyes rolling upwards (tonic movements of the eye), lip smacking, and autonomic symptoms such as flushing and tachycardia
  • EEG can be normal, though can show interictal spike and wave discharges
  • Children may become seizure free (33–80%) though some will go on to develop GTC seizures (40%)
  • May develop problems with cognition, social adaptation, or behavior
  • Usually well controlled with ethosuximide
    • or valproate
    • or lamotrigine
66
Q

infantile spasms (west syndrome)

A
  • Rare, very dramatic form of epilepsy mostly in 1st year of life
  • Triad of
    • infantile spasms
    • EEG pattern of hypsarrhythmia
      • continuous multifocal spike and slow waves with high amplitude on ECG
    • developmental delay
  • Any disorder that produces brain damage can be associated with infantile spasms (prenatal, perinatal, postnatal disorders)
    • underlying structural cause!!
  • Diminish/disappear by the 4-5th year of life
  • Underdeveloped psychomotor development from the spasms in 70–90%
    • Milestone loss
  • Spasms begin with a sudden, rapid, tonic contraction of the trunk and limbs that gradually relaxes over 0.5–2 seconds •
  • Intensity may vary form subtle head nodding to a powerful contraction of the body
  • Goals: best quality of life with few seizures, the fewest side effects from treatment, and the least number of medications
  • treatment:
    • ACTH, vigabatrin, vitamin B6 and prednisone are mainstays of treatment
      • benzos, valproic acid, lamotrigine, topiramate, zonisamide, and levetiracetam
  • Ketogenic diet
  • poor prognosis
67
Q

Lennox Gastaut syndrome criteria and causes

A
  • Having multiple seizure types: tonic and atonic seizures, include absence and myoclonic seizures and non-convulsive status epilepticus
  • Developmental Delay or regression with or without other neurologic abnormalities;
  • Causes
    • Genetic disorders
    • Neurocutaneous syndromes (tuberous sclerosis
    • Encephalopathies following hypoxic-ischemic insults
      • Trauma at birth
    • Meningitis
    • Head injuries
    • 40% have cryptogenic etiology; these children are commonly found to have genetic disorders
68
Q

Lennox gastaut syndrome treatment

A
  • No drug very effective
  • Rufinamide first approved and clobazam
  • Valproic acid, lamotrigine, topiramate, rufinamide, felbamate, clobazam
  • Carbamazepine/tegretol can worsen drop attacks
  • Ketogenic diet
  • Corpus callosotomy
  • Vagus nerve stimulation
69
Q

juvenile myoclonic epilepsy

A
  • typically a healthy young teenager with one or more of the following seizures:
    • Absence seizures
    • Myoclonic jerks
    • Generalized convulsions
    • Myoclonus and generalized seizures often occur shortly after awakening in the morning
  • control with AED
    • Valproic acid, lamotrigine, topiramate, levetiracetam, and clonazepam
  • Lifelong disorder, treatment indefinitely
  • Good prognosis, normal cognitive development, seizures generally respond well to treatment
70
Q

ketogenic diet

A
  • high fat, protein causing ketosis = anti seizure effect
  • 4 parts fat: 1 part protein and carbs
  • need supervision by dietician
  • better in children than adults
  • don’t do longer then 2 years
  • complications:
    • GI
    • metabolic acidosis
    • osteopenia (need Ca and vitamin D supplements)
71
Q

when is surgery considered with epilepsy?

A
  • children who are medically refractory, meaning failed 3 or more trials of medications
  • severe
  • well localized epilepsy respond best to remove
72
Q

febrile seizures criteria

A

benign condition

  • > 38°C (100.4°F)
  • 6 months to < 5 years of age
  • No CNS infection or inflammation
  • No acute systemic metabolic abnormality that may produce convulsions
  • No previous afebrile seizures
73
Q

simple febrile seizure

A
  • Most common type of febrile seizure
  • Seizures that last < 15 minutes
  • No focal features
  • If they occur in a series, last less than 30 minutes
74
Q

complex febrile seizure

A
  • Last > 15 minutes
  • Have focal or post-ictal paresis
  • If the occur in a series, last more than 30 minutes
75
Q

febrile seizure management

A
  • Antipyretics, AED = not useful
  • Possible causes: any viral or bacterial illness or rarely an immunization, HSV 6 commonly causes febrile seizures, likely d/t high fever), MMRV vaccine 1 week afterwards & family hx of seizures
  • If the child has focal or prolonged seizures, generalized or focal EEG abnormalities, repeated episodes of febrile convulsion during a febrile illness (complicated febrile seizures), or seizures associated with fever and without fever = sus more serious underlying cause (i.e., bacterial meningitis, encephalitis)
76
Q

risk factors for recurrence of febrile seizure

A
  • 1st one before 18 months
  • low degree temp during seizure
  • fever occurs AFTER seizure
  • family hx of febrile seizures
77
Q

multiple sclerosis

A
  • autoimmune ​inflammatory and neurodegenerative disorder of CNS; demyelination of the brain, the spinal cord, optic nerves
  • Ages 20 to 50
  • Unknown cause; autoimmune; genetic and environmental influence.
  • further from equator = higher risk
  • Silent lesions that may be seen on an MRI; no symptoms.
  • women> males.
78
Q

multiple sclerosis sx’s

A
  • non-specific
  • most common: visual distrubances/eye pain, paresthesias or weakness of limbs, or facial pain
  • if lesions in brain stem = see double vision, facial paralysis, numbness, vertigo.
    • cerebellum = poor coordination or tremors
    • optic nerve = impaired vision
  • pain with movement
  • very vague complaints
    • fatigue
    • depression
    • pain, paresthesia
    • sexual dysfunction
    • spasticity
    • tremor
    • weakness
    • ataxia
  • spinal cord lesions = limb weakness, decrease in sensation, and possibly bowel and bladder symptoms
79
Q

if think it’s MS, get

A

CBCs, ESR, LFTs, renal function panel, calcium, glucose, thyroid panel, B12, zinc. HIV or Lyme titer

Gold standard diagnosis: MRI (or LP)

80
Q

MS differentials

A
  • vascular, metabolic things, infections, or neoplasm.
  • inflammatory processes like lupus or vascular disorders like a stroke.
  • metabolic disorders, like B12 or zinc, and then infection.
  • Lyme, HIV
81
Q

MS treatment

A
  • care team (OT, PT, PA, neurologist, social workers, psych)
  • DMT (decrease exacerbation, MRI activity, slow disability rate)
    • start asap with 1st sx
    • vitamin D
    • immunosuppressive
    • monoclonal antibody (-zumab)