WEEK 3 - Infectious Disease & Resistance Flashcards
What are characteristics of bacteria?
Only have single stranded, circular DNA, no plasma membrane.
No membrane bound organelles.
70S ribosomes for protein production.
No nucleus, DNA lies in the nucleoid.
Flagella for movement towards food and away from immune mechanisms of host.
May have plasmids - additional DNA (usually gram -ve).
Cell wall (peptidoglycans, for maintaining shape and rigidity, for multiplication, may contribute to resistance.
What colour do Gram positive bacteria stain and why?
Purple, stain is trapped in thick peptidoglycan wall.
What colour do Gram negative bacteria stain and why?
Red, thin peptidoglycan wall does not retain crystal violet, is counterstained with safranin to produce red.
What are characteristics of viruses?
Acellular - cannot replicate on own, requires host mechanisms.
Viral genome DNA or RNA packaged into capsid (protein coat).
Capsid = rigid, protects against envi conditions, resistant to acid/drying, helps transmission (faecal-oral).
Some have a lipid membrane envelope in addition to capsid which is only maintained in aqueous solutions (transmission via bodily fluids).
When do fungi/parasitic/protozoa infections occur?
When there is disruption in the protective barriers (skin, mucous membranes) or due to defective immune system (immunosuppression).
Are fungi, parasites and protozoa prokaryotes or eukaryotes?
Eukaryotes
What characteristics do eukaryotes have?
Membrane bound organelles. Nucleus Mitochondria 80S ribsomes Smooth ER (for detox, lots in liver) Rough ER Golgi apparatus
What are prions and how are they transmitted?
Completely made up of protein.
Transmitted by electrical transmission, eating food that is contaminated with it, medical procedures.
Define pathogen
An agent able to evade the various physiological defences of the human host to cause infection.
Define infection
When an infectious agent enters the body, increases in number and causes damage to the host.
Define commensalism
Where the host and microbe live together with no effect on each other’s life cycle i.e. normal flora of the skin (Candida albicans protects our skin from other pathogenic agents).
Define parasitism
Unequal relationship ‐ one benefits to the detriment of another; this is the case in all infections.
Define symbiosis
Where species live together for their mutual benefit i.e. human host and the gut flora ‐ bacteria get warm, moist, protected environment; host cell ‐ digestion.
Define opportunistic infection
When the healthy human defences are weakened infection by organisms not generally causing an infection in healthy humans i.e. Pneumocystis carinii (Jirovecii) ‐ known to cause pneumonia in people who have AIDS, won’t happen to a healthy person.
Define nosocomial infection
Infections transmitted in hospitals; some may be opportunistic affecting seriously ill (immunocompromised) patients, others occur because of the special nature of the hospital environment i.e. Methicillin‐ Resistant Staphylococcus aureus (MRSA); VRE.