Week 3: Ch. 9 - Ligament Healing

Question 1

Connective Tissue

Answer 1

• Bind cells together to form and organize tissues, organs, and systems
• Provides mechanical link between musculoskeletal junctions and joints

Question 2

Connective Tissue Functions

Answer 2

Mechanical support for bones and soft tissues
* Absorb shock
* Provide stability
* Provide mechanical link system between bones
* Transmit forces

Intercellular exchange of oxygen, blood, water, gases, cells, and wastes

Question 3

Extracellular Matrix Components

Answer 3

1. Elastin
2. Collagen
3. Ground Substance
4. Proteoglycans
5. Glycosaminoglycans
6. Lipids, Phospholipids Proteins,
   Glycoproteins

Question 4

Elastin

Answer 4

Found in tissue that requires high levels of physiologic motion (elasticity)

Unique ability to deform under stress and return to original shape and orientation
* Can elongate up to appx 70%

Question 5

Collagen

Answer 5

• Most abundant component of connective tissue
• 12-19 types
• Properties of connective tissue dependent on type of collagen in extracellular matrix
• Network of crosslinks = stability & strength of extracellular matrix

Question 6

Key Members of Collagen

Answer 6

• Amino acids
  Resists tensile forces
• Fibroblasts:
  Stimulate collagen synthesis by assembling polypeptides**

Question 7

Ground Substance

Answer 7

Facilitates intracellular exchanges and provides mechanical support

Question 8

Proteoglycans and Glycosaminoglycans (GAGs)

Answer 8

• Responsible for Compressive strength of cartilage (strength, stiffness, rigidity, and flexibility)
• Hydrophilic: attract and bind to water