Week 3 Flashcards
At what gestation can a fetus survive independently outside the uterus?
From 32 - 34 weeks.
At what gestation is the sex of the fetus able to be distinguished externally?
12 weeks.
From when is the placenta fully established?
From 8 - 10 weeks. It will be full size by 4 months.
What is the purpose of maternal lacunae?
It allows primitive transfer of nutrients etc from mother to fetus from the endometrial glands.
How are maternal lacunae developed?
The syncytiotrophoblast errodes the glands and blood vessels of the endometrial tissue to form lacunae (spaces) where nutrients can pass. It is present by day 13.
By the end of the first trimester, these spaces develop into intervillous spaces of the placenta, where blood enters providing fluid with a higher o2 content for fetal exchange.
What are the chorionic villi?
Finger-like projections that develop due to the cytotrophoblast invading areas of syncytiotrophoblast between the lacunae. Blood vessels develop in the chorionic villi by 18 - 21 days.
There are two types, anchoring or branch. Branch villi facilitate diffusion, while anchoring villi attach the placenta to the decidua.
What are the chorion and the amnion?
The two layers of the chorioamniotic membrane which are separated by 200ml of amniotic fluid and mucous produced by the amnion.
The Amnion is the membrane around the embryo/fetus, the inner membrane.
The chorion is the membrane closest to the decidua, or the outer membrane.
Where does the amnion attach to the fetus?
At the site of the umbilical cord.
Which membrane contains blood vessels. The amnion or the chorion?
The Chorion.
What are the functions of amniotic fluid?
Allow fetal movement;
Protect fetus from changes in pressure and temperature;
Protection from infection (through antibacterial factors).
How is amniotic fluid produced/formed?
Initially by secretion by amniotic cells;
Then by diffusion of fluid from the interstitial fluid of the decidua parietalis and from the blood in the intervillous spaces of the placenta - across the amniochorionic membrane to the amniotic cavity.
What is amniotic fluid comprised of?
98 - 99% water;
Remaining is electrolytes, creatinine, urea, bile, renin, glucose, hormones, fetal cells, lanugo and vernix.
What is the other name for the primary yolk sac?
The umbilical vesicle.
What are the four roles of the placenta?
- Transport: of respiratory gases O2 and CO2, nutrients, hormones, waste products, electrolytes;
- Immunological: provides an effective barrier against most large bacterial microorganisms, but not most viruses or smaller bacteria. Protection is instead provided by the transport of maternal antibodies;
- Endocrine: hormones that help maintain pregnancy are synthesised by the placenta such as oestrogen, progesterone, hPL and hCG;
- Metabolic: the placenta synthesises glycogen, cholesterol, fatty acids and enzymes which are used by the embryo/fetus and the placenta. This is mostly important in early pregnancy before the fetal/maternal circulation is established.
What is wharton’s jelly?
It is a jelly like substance in the umbilical cord that suspends and protects the umbilical blood vessels.
What is the approximate size of a placenta at full term?
20 cm in diameter and 2.5cm thick at the centre.
What is the name given to the lobes of the placenta on the maternal side and how many are there in a normal placenta?
There are 15 - 20 cotyledons in a normal placenta.
What are the two “plates” of the placenta?
Basal plate: maternal tissue along the wall of the uterus that contains maternal blood vessels.
Chorionic plate: fetal tissue containing umbilical blood vessels that push into lacunae to allow diffusion of nutrients/waste products and gas exchange from the maternal blood to the fetal circulation.
True or False: The umbilical cord is wrapped in amnion membrane?
TRUE.
How many blood vessels are contained in the umbilical cord?
There are three: one vein, and two arteries.
What is calcification and how is it identified?
Calcification of the placenta is where deposits of lime salts occur on the surface of the maternal side and they appear as whitish/grey spots and are “gritty” to the touch.
They’re associated with maternal smoking and high blood pressure.