Week 3 Flashcards
(110 cards)
Explain the classification of drugs in terms of teratogenicity.
- Category A, B1, B2, B3, C, D, X?
What is a Teratogen?
Give some examples.
Teratogen: an environmental factor that causes a permanent structural or functional abnormality, growth restriction, or death of the embryo or fetus.
- Effects depend on multiple factors.
- The pharmacological properties, dose, and regimen of drug exposure determine the risk of developing teratogenic birth defects.
- Stage of pregnancy in which exposure occurs.
- It’s important to note that the effects of teratogens on the fetus can be influenced by the timing of exposure. The first trimester (weeks 1 to 12) is the most vulnerable period for organ development, making the fetus more susceptible to teratogenic effects during this time.
List 8 Types of Teratogens.
Explain the effects of common teratogens on the fetus at different gestational ages - timeline?
- Alcohol
- Tobacco (Nicotine)
- Illicit Drugs (e.g., Cocaine, Heroin, Methamphetamine)
- Prescription Medications (e.g., Thalidomide, Isotretinoin, Valproic Acid)
- Infections (e.g., Rubella, Cytomegalovirus, Zika virus)
- Environmental Toxins (e.g., Lead, Mercury, PCBs)
- Radiation (e.g., X-rays, Ionizing radiation)
- Hyperthermia (High Body Temperature)
Teratogenicity - Maternal conditions
- Obesity? (7)
- Graves’ Disease? (6)
- Preterm birth
- Stillbirth
- Neural tube defects
- Congenital heart disease
- Cleft lip, cleft palate
- Limb reduction abnormalities
- Macrosomia
Teratogenicity - Maternal conditions
- Hypothyroidism?
- Phenylketonuria?
Hypothyroidism
1. Congenital hypothyroidism
2. Congenital iodine deficiency syndrome
Teratogenicity - Alcohol: fetal alcohol syndrome (embryo-fetal alcohol syndrome)
- Epidemiology?
- Mechanism of Teratogenicity?
- Clinical Features - 7 Dysmorphic features?
Alcohol: fetal alcohol syndrome
- Epidemiology: Most common cause of teratogenic damage in children (0.2–1.5 per 1,000 live births), Most common preventable cause of intellectual disability in the US
- Mechanism of teratogenesis: Failed neuronal and glial cell migration
Teratogenesis - Cigarette smoking during pregnancy
- Mechanism of teratogenesis?
- 6 Effects?
Cigarette smoking during pregnancy - Mechanism of teratogenesis
Nicotine: ↑ catecholamine release → vasoconstriction of uteroplacental blood vessels → compromised blood flow and oxygen delivery to the fetus
Carbon monoxide: ↑ COHb causes tissue hypoxia
Teratogenicity - Cocaine & Opioids
- Mechanism of teratogenesis of cocaine?
- 4 Effects of cocaine on the fetus?
- Mechanism of teratogenesis of opioids?
- 6 Effects of cocaine on the fetus?
Cocaine Use in Pregnancy
- Mechanism of teratogenesis: cocaine → vasoconstriction of the uteroplacental placental vessels→ compromised blood flow and oxygen delivery to the fetus
- Effects
1. Intrauterine growth retardation
2. Low birth weight
3. Preterm labor
4. Placental abruption
What are TORCH infections?
Describe the Barker hypothesis in relation to the implications for health care provision and planning.
- 4 Key points?
- 6 implications?
The Barker hypothesis, also known as the Developmental Origins of Health and Disease (DOHaD) hypothesis, is a concept proposed by epidemiologist David Barker in the late 1980s. The hypothesis suggests that the environment and nutrition experienced during fetal development and early life can have long-term effects on an individual’s health and disease risk later in life.
Cesarean section
- 2 Advantages?
- 2 Disadvantages?
- 4 Maternal indications for a Primary cesarean delivery?
- Maternal indications for Secondary cesarean delivery?
- 3 Indications for Emergency cesarean delivery?
Advantages
1. Safest method of birth if maternal and/or fetal health is compromised by a vaginal delivery
2. Fetal birth trauma is rare.
Disadvantages
1. Postoperative complications
2. Long recovery period
Fetal indications for Caesarean section
- Primary caesarean delivery? (4)
- Emergency caesarean delivery? (3)
Fetal indications for Caesarean section
Primary caesarean delivery
1. Fetal growth retardation with circulatory depression
2. Premature birth, if further risk factors are present, e.g., infection
3. Fetal malformations that hinder a natural birth (e.g., severe hydrocephalus)
4. Multiple pregnancy with a significant difference in fetal weight
Emergency caesarean delivery
1. Immediate threat to life of fetus
2. Pathological CTG (particularly persistent, severe fetal bradycardia)
3. Fetal acidosis
List 8 Indications for C-Section?
Possible Complications of Cesarean Section
- 10 Maternal?
- 2 Fetal?
Risks for your baby
The most common problem affecting babies born by caesarean section is temporary breathing difficulty. There is also a small risk of your baby being cut during the operation. This is usually a small cut that isn’t deep. This happens in 1 to 2 out of every 100 babies
delivered by caesarean section, but usually heals without any further harm.
5 Benefits of a C-Section?
6 Complications of a C-Section?
What are the 2 options for Mode of delivery after cesarean delivery?
TOLAC: A planned or attempted childbirth in a mother who has had a prior cesarean delivery. Results in vaginal birth after cesarean (VBAC) if successful or a repeat cesarean delivery if unsuccessful. Associated with increased risk of rupture of the cesarean scar on the uterus. Contraindicated in patients with a history of > 2 prior low-transverse cesarean deliveries and classic cesarean delivery.
List 2 Indications for a TOLAC?
3 Indications for Planned repeat cesarean birth?
Describe the issues around vaginal birth after caesarean section (VBAC).
What are 4 Factors Increasing success in VBAC and 9 Factors reducing success in VBAC?
- Previous vaginal birth, especially successful VBAC, is the strongest predictor of success, with VBAC rates of 87-91% reported in that group.
- Induced labour, no previous vaginal birth, a BMI greater than 30 Kg/m2, and previous Caesarean section for dystocia are factors that all reduce the success rate; Landon reported if all four are present then the success rate was only 40%.
4 Benefits of a successful VBAC?
7 Risks of VBAC?
5 Benefits and 3 risks of elective repeat Caesarean section at 39 weeks?
What is the definition of Operative Vaginal Delivery?
- Can we avoid operative vaginal delivery? (7)
Operative Vaginal Delivery = Delivery of the fetus by Forceps or Vacuum extractor.
Avoiding an Operative Vaginal Delivery
1. Continuous support in labour
2. Correct posture in labour
3. Mobilisation in labour
4. Avoidance of epidural
5. Avoidance of epidural in early labour
6. Delayed pushing when epidural used
7. Judicious use of oxytocin in 2nd stage
How are operative vaginal deliveries classified?
Classification of operative vaginal delivery
Extraction is classified by the status of the fetal head at the time of vacuum application and the degree of rotation necessary. The lower the classification, the less the risk of complications.