Week 2 - Somesthesis Flashcards
how can tactile receptors be divided? what are examples of cells?
- slowly adapting mechanoreceptors, which respond to enduring stimulus (Merkel and Ruffini, types I and II)
- rapidly adapting mechanoreceptors respond only at onset and sometimes termination of long-lasting stimulus (Meissner and Pacinian)
how do Pacinian corpuscles respond to stimuli?
rapidly adapting mechanoreceptor, so its ability to respond is based on unique lamellar accessory structure
-responds w/ single AP for each phase of stimulus
what happens on hairy skin?
slight movement of any hair on the body stimulates hair mechanoreceptors made of nerve fibers entwining base of hair
-although each receptor has unique properties, sensory experiences of touch, pressure, and vibration are different from tactile sensation from normal stimuli
how is “wet” skin felt?
no receptor for “wet” skin, but the combination of all receptors conveys it
what does the two-point discrimination threshhold mean?
ability to differentiate between stimuli of same quality that differ in place, magnitude, and spatial pattern
- due to relationship between receptor density and receptive field size
- receptive field is part of skin directly innervated by receptor terminals and area of adjacent tissue through which a stimulus can be conducted to receptor
- areas of skin that are most sensitive and have greatest capacity for fine spatial discrimination have high density of receptors
- receptors have smallest receptive fields, and largest number of receptive fields per unit area
how do 2-point discriminations differ for fingers, arms, and back?
finger: 2-3 mm (highest innervation and lowest pressure thresholds)
forearm: 20 mm
back: 40 mm (lowest innervation and highest pressure threshold)
how do Merkel’s receptors, Meissner’s corpuscles, and Pacinian corpuscles differ in stimulus resolution?
Merkel’s - slowly adapting, provide spatial recognition
Messner and Pacinian - rapidly adapting, provide timing info
what are the 2 major ascending systems that carry somatosensory info to cerebral cortex?
- dorsal column-lemniscal system (mediates high tactile sensations like vibration and proprioception)
- anterolateral system (pain, temperature)
- tactile info only crude touch and pressure sensations, poor localizing ability on body, and little capability for fine intensity discrimination
how does somatosensory info enter spinal cord?
peripheral mechanoreceptors are innervated by afferent axons whose cell bodies lie in dorsal root ganglia
-on entering spinal cord, the large myelinated fibers pass medially into lateral margin of dorsal columns
what is the laminar organization of the spinal cord for somatosense?
- medial branch turns upward in dorsal columns, and continues via dorsal column pathway to brain
- lateral branch divides many times to give off multiple terminations in cord
- participate in mediation of local spinal activity
what is the somatopic organization of the dorsal columns?
at the level of the spinal cord, the first segregation of sensory information begins
- afferent fibers of different receptors take specific routes on way to central projections
- within dorsal columns, these modality segregated axons are arranged in highly ordered manner
- sacral axons enter spinal cord and are packed near midline
- axons added at higher levels are packed at successively more lateral positions
what is the entering central ascending pathway in the brainstem?
nerve fibers entering dorsal columns pass up columns on ipsilateral side to caudal medulla, where they synapse in the dorsal column (cuneate and gracile) nuclei
how are 2nd order neuron receptive fields developed?
at level of dorsal column, nuclei receptor neurons converge onto single second order neurons
- receptive fields become larger b/c they get convergent input from many primary neurons, each w/ a slightly different but overlapping receptive field
- become more complex, b/c unlike simple excitatory receptive field of sensory receptor, the receptive field of the second order neurons has both excitatory and inhibitory regions
lateral inhibition with a punctate stimulus
idealized point source of stimulation
-activates several touch receptors to varying degree, since primary unit influences its own secondary unit plus nearest neighbors
two point discrimination with punctate stimuli
two receptive fields are stimulated by points separated by a third receptive field