Week 2: Gut micro biome and probiotics

Question 1

Disorders that are impacted by gut microbiome

Answer 1

• obesity
• IBD: IBD patients show reduction of diversity of micro biome. Loss of normal anaerobic bacteria such as Bacteroides, Eubacterium, Lactobacillus
• IBS
• allergies
• NEC
• clostridium difficile

Question 2

effect of probiotics on various diseases

Answer 2

• Pouchitis: effective for treatment
• Crohns disease: probiotics have no proven role
• ulcerative colitis: probiotics similar to ASA effect
• antibiotic assoc. diarrhea: not all probiotics are effective, mainly lactobacillus and saccharomyces
• C difficile diarrhea: effective in severe recurrent disease
• acute diarrhea: shortens duration of illness about 1 day
• atopic dermatitis: mild efficacy
• NEC: decrease incidence of severe NEC
• URI: lower # developing URI and decrease antibiotic use