Week 2: Diabetes Flashcards
What is a concern w/ metformin use?
r/f lactic acidosis
What needs to be monitored w/ metformin use?
renal function, B12 levels
With what GFR should metformin be d/c’d?
30 or less
Wen should you avoid SGLT2 inhibitors?
renal impairment
What is a benefit of SGLT2 inhibitors?
may hinder progressive CVD and renal dysfunction;
may promote weight loss
What is an increased risk w/ SGLT2 inhibitors?
UTI, genital infections, Fournier gangrene, bone fractures
What is a benefit of GLP-1 agonists?
decrease in CV events and progressive renal dysfunction
weight loss
When should you exercise caution with GLP-1 agonists?
pancreatitis, renal disease
when are GLP-1 agonists CI?
hx of MEN syndrome and thyroid C-cell tumors
When are DPP-4 inhibitors CI?
pancreatitis
When should you exercise caution w/ DPP-4 inhibitors?
renal impairment
What drugs do DPP-4 inhibitors interact w/
ACE inhibitors
What other effect do TZDs have on the body?
improves TGs, HDL
