Week 2 Flashcards

1
Q

What are the two main types of Nervous systems?

A

Central Nervous System (CNS) and Peripheral Nervous System (PNS)

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2
Q

What does the Central Nervous System consist of?

A

Brain

Spinal cord

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3
Q

What does the Peripheral Nervous System consist of?

A

Somatic Nervous System (SNS)

Autonomic Nervous System (ANS)

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4
Q

What does the Somatic Nervous System (SNS) consist of?

A
Afferent nerves (incoming)
Efferent nerves (outgoing)
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5
Q

What does the Autonomic Nervous System consist of?

A
Afferent nerves (incoming)
Efferent nerves (outgoing) which have Parasympathetic (rest and digest) and Sympathetic (fight or flight)
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6
Q

Central Nervous System (CNS)

A

Brain and spinal cord
Encased in bone
Networks of interconnected neurons
Processing of information

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7
Q

Peripheral Nervous System (PNS)

A
Outside the skull and spine
Nerves – bundles of separate neurons
Transmission of information
Connects the CNS with the rest of the body
Somatic Nervous System (SNS)
Voluntary
Interaction with the environment
Autonomic Nervous System (ANS)
Involuntary
Regulate the body
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8
Q

Somatic Nervous System (SNS)

A
Voluntary
Interaction with the environment
Afferent
Incoming signals
Sensory info into the CNS
Exteroceptive sense organs 
Information to enable interaction with the world
Efferent
Outgoing signals
Motor commands from the CNS
Skeletal Muscle
Facilitate bodies interaction with the world
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9
Q

Autonomic Nervous System (ANS)

A
Involuntary
Regulate the body
Afferent
Incoming signals
Sensory info into the CNS
Interoceptive sense organs (viscera and blood vessels)
Information about the body’s internal state  
Efferent
Outgoing signals
Motor commands from the CNS
Smooth and cardiac muscle and glands
Change the body’s internal state
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10
Q

ANS Efferents

A

Sympathetic
Fight or flight
Stimulate organs and release hormones to wind things up
Mobilise energy sources
Increase blood flow and respiration
Supress non-essentials
Parasympathetic
Rest and digest
Counteract sympathetic to wind things down
Stimulate digestion and restorative functions
Conserve energy

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11
Q

CNS / PNS Interface

A

Cranial Nerves
12 pairs
Connect directly to the brain
Some purely sensory, some purely motor, some both

Spinal Nerves
31 pairs
Connect to the spinal cord
All are both sensory and motor

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12
Q

Neurons

A

Main functional cells of the nervous system

Collect, integrate and transmit information

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13
Q

Glia

A

Glia support neurons

Numerous types and many function

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14
Q

Clusters of cells within the CNS and PNS

A

CNS - Nuclei
PNS – Ganglia
in grey matter

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15
Q

Clusters of axons within the CNS and PNS

A

CNS - Tracts
PNS – Nerves
in white matter

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16
Q

4 Main Types of Neuron

A

Unipolar neuron- Sensory neurons transfer information from receptor cells to higher nerve cells
Bipolar neuron- Connecting adjacent cells typically in sensory system (e.g. retina)
Multipolar neuron- Transfer information between cells usually long distance; can collect and integrate info from many cells
Multipolar interneuron- Local connections collect and integrate info from many cells

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17
Q

4 Main Types of Glia

A

Oligodendrocytes- Myelination in CNS
Schwann Cells- Myelination in PNS
Microglia- Immune function
Astrocytes- Numerous structural and functional support

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18
Q

The Spinal Cord

A

13-14 million neurons
Protected by the vertebral column (and meninges)
Doesn’t go full length of the spine
Loose bundle of nerves below L2 – Cauda Equina (horses tail)
Messages to and from the brain
Also simple processing – reflex arcs

19
Q

The spinal cord cross section consists of?

A
Dorsal horn
Dorsal root
Dorsal root ganglion
Ventral horn
Ventral root
Spinal nerve
20
Q

The two main types of nerves to the spinal cord are?

A

Unipolar afferent neurons join the dorsal horn - both somatic (skeletal / sensory) and autonomic (internal organs) systems.
Multipolar efferent neurons have their cell bodies in the ventral root. Their axons project out to somatic and autonomic systems.

21
Q

The development of the brain and the neural tube

A

neural plate border, neural plate and epidermis
convergence of the neural plate borders to create a neural fold
the formation of the epidermis, neural crest an neural tube

22
Q

The sections of the brain

A

Forebrain
Midbrain
Hindbrain
Spinal cord

23
Q

Five Divisions of The Brain

A
Forebrain
-Telencephalon
-Diencephalon
Midbrain
-Mesencephalon
Hindbrain
-Metencephalon
-Myelencephalon
24
Q

Brainstem

A

Connects forebrain to spinal cord
White matter outside with grey matter inside in discrete nuclei
3 major levels
Myelencephalon
Metencephalon
Mesencephalon
All head muscles supplied by cranial nerves from the brainstem

25
Myelencephalon
Medulla Caudal brainstem – blends into spinal cord Primarily axonal tracts Pyramidal tracts – ‘decussation of the pyramids’ Head and neck movement Vital functions Portion of reticular formation (net-like formation) - arousal.
26
Mesencephalon
``` Midbrain -tectum and tegmentum Tectum superior and inferior colliculi Visual and auditory orienting of attention Multisensory integration ``` Tegmentum Portion ventral to tectum Periaqueductal grey matter Substantia nigra
27
Mesencephalon- Parkinson’s Disease
``` Loss of dopamine neurons in SN Project to basal ganglia Important for movement control Tremor or shaking Muscle rigidity or stiffness Slowing of movement Stooped posture Balance problems. ```
28
Diencephalon
Forebrain 2 major parts Thalamus Hypothalamus 2 major endocrine glands Pituitary gland Pineal gland
29
Thalamus
Relay station – all sensory except smell relays through thalamus Also receives many cortical projections Integration of bottom-up inputs and top-down Many separate nuclei Lateral Geniculate Nucleus first synapse after the optic nerve leaves the eye Medial Geniculate Nucleus Auditory relay Ventro Posterior Nucleus Sensorimotor relay
30
Hypothalamus
Ventral part of diencephalon Control centre for autonomic nervous system Inputs from many brain and body systems Outputs to brainstem (ANS) and pituitary gland (endocrine) Homeostasis Regulation of motivated behaviours – eating, sleeping, sexual
31
Telencephalon
Forebrain Collection of subcortical nuclei Cerebral cortex
32
Basal Ganglia
Control of movement Learning and motivation Striatum – caudate + putamen
33
Limbic System
Midline structures circling the thalamus Regulation of motivated behaviours - The Four Fs Affect/emotion Amygdala – learned fear response; recognition of emotion in others Hippocampus – long term memory
34
Cerebral Cortex
Layer of grey matter covering the cerebral hemispheres Folded – Gyri (ridges) and Sulci (fissures) 2 Hemispheres connected by corpus collosum 4 lobes Many regions or areas based on location (e.g. PFC), function (e.g. FEF), or cytoarchitecture (e.g. Brodmann areas) 28 billion neurons >1 trillion synapses >80% human brain mass
35
The four parts of the cerebral cortex
Frontal Lobe Thinking, planning, executive functions, motor execution Parietal Lobe Somatosensory perception, spatial perception Temporal Lobe Auditory, language, long term memory, emotion Occipital Lobe Visual
36
Main Neuron Types
Pyramidal Most common cortical neuron Large bodies, multipolar, long axon goes down and inward through layers Projection neurons – connect disparate brain regions or leave the brain (to spinal cord) Stellate small, star-shaped short axons; transmit info laterally Local – interneurons
37
Layers of Neocortex
Most cortex neocortex – new 6 layered outer covering of the cerebral hemisphere Each layer differs in the relative concentration of stellate and pyramidal cells, in the relative size and concentration of cell bodies Layer I - axons and dendrites, few cell bodies Layer II - densely packed stellate cells , a few pyramidal cells Layer III - Loosely packed stellate cells; intermediate sized pyramidal cells Layer IV is thick in sensory areas – Input Layer V – mainly pyramidal cells with long axons - in motor areas - output Layer VI - pyramidal cells of various sizes; loosely packed stellate cells
38
Protecting the Brain
``` Physical protection from mechanical injury Skull 3 Meninges (Dura Mater, Pia Mater, Arachnoid) – membranous coverings around the brain and spinal cord Cerebrospinal fluid (CSF) – supports and cushions ``` Chemical protection – maintaining chemical balance The blood-brain barrier Tightly packed cells along the blood vessel walls of the CNS prevent entry of many (large) molecules. Good and bad (eg L-Dopa)
39
Physical protection of the brain - in order
``` Scalp Skull Dura Mater Arachnoid membrane Sinus Arachnoid membrane Sub-arachnoid space Artery Pia mater maninx Cortex ```
40
The ventricles
``` Lateral Third Cerebral aqueduct Fourth Central canal ```
41
Cerebrospinal Fluid
Produced by choroid plexuses in ventricles Circulates subarachnoid space, ventricles and central canal Excess drains into sinuses in the dura mater If drainage is blocked - hydrocephalus
42
Commisurotomies / callosotomies
Antecedent: usually sever epilepsy Procedure: callosotomy, anterior commissurotomy Consequence: reduction of seizures Behavioural consequence: very little Experimental consequence: sensory information presented to one hemisphere is not available to guide behaviour in the other hemisphere
43
Split Brains
Visual information – left visual field to right hemisphere and right visual field to left hemisphere Intact brain – information can cross between hemispheres via the corpus callosum Callosotomy – lose communication Left hemisphere ignorant of left visual field Right hemisphere ignorant of right visual field Left hemisphere ignorant of left visual field Right hemisphere ignorant of right visual field But – speech typically in left hemisphere
44
Split Brains- explain your behaviour
confabulation- subconsciously make reasons for what they say or do