week 2 Flashcards

Question

thought interference

Answer 1

insertion withdrawl broadcast

Answer 2

a false belief - anorexia

Answer 3

recurrent , intrusive, distressing ideas - patient recognises it on their own

Answer 4

perception with no stimulus

Answer 5

orientation - time place and person

Answer 6

the persons understanding of their presentation and their needed treatment

Answer 7

drugs which are designed/ targeted for specific groups of patients targets can be found by looking for molecular markers

Answer 8

predict which patients will benefit from specific treatment help chose which drug to use the basis of precision medicine eamples include EGFR mutations in lung cancer , RAF mutations in melanoma

Answer 9

inform about outcome regardless of treatment may help chose which patients to treat , but now how to treat them examples include CTCs in breast cancer

Answer 10

we don't have targeted drugs for most patients cancer usually isn't a single mutation disease but more a complex cascade of events to understand tumour biopsy is needed , not ll patients will have one and they cant always be performed KEY TO SUCCESS - precise matching of the right drug for the right patient at the right time

Answer 11

cancer of bone marrow - myeloid cells- average age diagnosis 65 incidence 1:100000

Answer 12

a drug that inhibits the action of Abl . it is a tyrosine kinase inhibitor . once daily oral meds . overall survival at 5 yrs is doubled to 60%

Answer 13

the most common eaxmple of chromosomal rearrangement - bcr-Abl gene translocation . the abl gene codes for tyrosine kinase . with the mutated brc-abl gene, the kinases are constantly turned on which stimulates downstream pathways to make cells divide.

Answer 14

where a section of a gene coding for one protein is physically attaching to a section of another gene coding for another protein. which gives rise to a hybrid protein.

Answer 15

drugs which target a specific process in an aberrant molecular pathway.- not all targets are in the cancer cell.

Answer 16

``` Targeting specific groups of patients using targeted therapies Aka “personalized medicine” “precision medicine” ```

Answer 17

1. we dont have a targeted drug for most patients | 2. cancer isnt usually a single mutation disease

Answer 18

is an AR signalling inhibitor that directly targets three stages of the AR signalling pathway

Answer 19

Some mutations were present throughout individual | tumour

Answer 20

Some were only present in a subset | of copies

Answer 21

``` appearance and behaviour speech mood and affect thought form and content perception cognition insight ```

Answer 22

```  Subjective: how the person tells you they feel in their own words  Objective: your impression of the person’s mood during the interview  Euthymic (normal)  Elevated/elated  Low/depressed  Anxious ```

Answer 23

 Reactive – appropriate reaction to the situation or topic being discussed  Flattened – limited emotional reaction  Blunted – no observed emotional reactions (specifically associated with psychosis)  Labile – excessive emotional fluctuations

Answer 24

perceived threat from others

Answer 25

belief that external events/objects are directly related to them (e.g. TV programme)

Answer 26

– insertion, withdrawal or | broadcast

Answer 27

false perception of a real stimulus

Answer 28

alertness orientation attention/concentration memory

Answer 29

The patient’s understanding of their | presentation and their need for treatment

Answer 30

↓ mood +/- anhedonia +/- fatigue Every day >2 weeks Biological: Diurnal variation, insomnia, ↓ appetite,↓ weight, ↓ libido, constipation, amenorrhoea

Answer 31

self / part of self is dead

Answer 32

persistent mild depression.

Answer 33

Cyclothymia -- or cyclothymic disorder -- is a relatively mild mood disorder. In cyclothymic disorder, moods swing between short periods of mild depression and hypomania, an elevated mood

Answer 34

``` Denial Anger Bargaining Depression Acceptance ```

Answer 35

``` electrotherapy controlled seizure and anaesthetic depression, mania , catatonia more effective than drugs side effect mem loss - rare ```

Answer 36

``` CBT OT SW- housing , financial , employment psycotherapy fam therapy ```