Week 2

Question 1

Older adults have a ________ GI pH which impairs drug absorption

Answer 1

Higher

Question 2

Primary organ responsible for drug metabolism

Answer 2

The liver

Question 3

Which route of administration has the fastest most complete absorption

Answer 3

Intravenous

Question 4

Con of sustains release capsule

Answer 4

More expensive than pills

Question 5

Hepatic first pass effect

Answer 5

Drug becomes inactive in the liver, must be administered through IV, subcutaneous, or IM

Question 6

How do drugs exit vasculature

Answer 6

By passing between capillary cells

Question 7

Rate of delivery of drugs in the body is determined by

Answer 7

Blood flow

Question 8

Requirements to pass the blood brain barrier

Answer 8

Lipid soluble or have a transport system
P glycoprotein present in BBB

Question 9

Risks of placental drug transfer

Answer 9

Decreased mental aptitude
Gross malformations
Low birth weight
Drug dependent baby (opioids)

Question 10

Most abundant and important protein binder

Answer 10

Plasma albumin

Question 11

Highly protein bound drugs make the duration of the medication _____?

Answer 11

Longer

Question 12

Biotransformation

Answer 12

Enzymatic alteration of drug structure in the liver