Week 1 Flashcards

1
Q

4 Key things to know about a medication

A
  1. Properties of an ideal drug
  2. Therapeutic objective
  3. Factors determining intensity of drug response
  4. Therapeutics
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2
Q

3 most important properties of an ideal drug

A
  1. Effectiveness
  2. Safety
  3. Selectivity
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3
Q

Other properties of ideal drugs

A

Reversible action
Predictability
Ease of administration
Freedom from drug interactions
Low cost
Chemical stability
Simple generic name

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4
Q

Therapeutic index

A

Achieve therapeutic effect without reaching toxic effect

Provide maximum benefit with minimum harm

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5
Q

Factors that determine intensity of drug response

A

Administration
Pharmacokinetics
Pharmacodynamics
Sources of individual variation

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6
Q

4 Major Pharmacokinetic processes

A

Drug absorption
Drug distribution
Drug metabolism
Drug excretion

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7
Q

10 Rights of Pharmacology in Nursing

A

Right drug
Right patient
Right responsibility
Right dose
Right time
Right assessment
Right documentation
Right evaluation
Right of patient to education
Right of patient to refuse care

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8
Q

CNO best practice regarding medication administration

A

Authority
Safety
Competence

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9
Q

Pharmacology in patient care

A

Pre administration assessment
Dosage and administration
Evaluating and promoting therapeutic effects
Minimizing adverse effects
Minimizing adverse interactions
Making PRN decisions
Managing toxicity

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10
Q

Pharmacology in patient education

A

Drug name and therapeutic category
Dosage size
Dosing schedule
Route and technique of administration
Expected therapeutic response and when it should develop
Non drug measure to enhance therapeutic response
Duration of treatment
Method of storage
Symptoms of adverse effects
Major adverse interactions
Whom to contact in emergencies

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11
Q

Nursing Process

A

Asessment
Diagnosis
Planning
Intervention
Evaluation

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12
Q

Pre administration assessment

A

Baseline data to evaluate therapeutic and adverse effects
Identify high risk patients
Assess patients capacity for self care

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13
Q

Types of nursing diagnosis

A

Problem focused
Risk
Health promotion
Syndrome
Possible

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14
Q

Planning

A

Define goals
Set priorities
Identify specific interventions
Drug administration
Interventions to enhance therapeutic effect and minimize adverse effects
Patient education
Establish objective criteria for evaluation

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15
Q

Implementation

A

Drug administration
Patient education
Interventions to promote therapeutic effects and minimize adverse effects

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16
Q

Evaluation

A

Therapeutic responses
Adverse drug reactions and interactions
Adherence to prescribed regimen
Satisfaction with treatment

17
Q

Canadian Regulatory Framework
Acts
Regulations
Guidelines
Policies

A

Act - provide legal authority to health Canada to regulate and oversee development and marketing of drugs

Regulation - legally enforceable interpretations of the act

Guidelines - not legally binding and allow flexibility in interpretation, general details, how to interpret and meet regulations

Policies - expand or modify interpretation of regulations

18
Q

Steps to new drug development

A

Randomized control trial

Preclinical testing

Clinical testing (4 phases)

***limited info for women and children, fail to detect all adverse effects

19
Q

Should nurses use generic or brand names?

A

Generic - more complicated than trade names but a single drug has multiple trade names with different active ingredients

20
Q

OTC drugs must have

A

A valid DIN to meet requirements for safety, quality and effectiveness

Ingredients list

Must be licensed and able to provide documents for evidence

21
Q

Is pharmacokinetics specific to drug classes or general processes

A

General processes

22
Q

What is pharmacokinetics

A

The movement of drugs through the body (metabolism and excretion)

23
Q

The principles of ADME

A

Absorption- how does it get it
Metabolism- how is it broken down
Distribution- where will it go
Excretion- how does it leave

24
Q

Factors affecting drug absorption

A

Rate of dissolution
Surface area
Blood flow
Lipid solubility
PH partitioning

25
Q

IV and advantages and disadvantages

A

Advantages
- rapid onset, use of irritant drugs
Disadvantages
- high cost, difficult and inconvenient, irreversibility, infection, fluid overload, embolism

26
Q

Intramuscular advantages, disadvantages, and barriers to absorption

A

Advantages
- poorly soluble drugs, depot prep
Disadvantage
- discomfort, nerve damage and bleeding risk
Barrier to absorption: capillary wall

27
Q

Oral advantages, disadvantages, and barriers to absorption

A

Advantages
- easy and convenient, self med, safer then injections, potentially reversible, minimal risks
Disadvantage
- absorption highly variable, inactivation of certain drugs
Barriers: epithelial cells in GI tract and capillary walls

28
Q

P-Glycoprotein

A

Transmembrane protein
Transports drugs out of cells
(Into bile, urine, maternal blood)

29
Q

To penetrate cell membranes, a drug must be _____?

A

Lipid soluble (lipophilic)

30
Q

Rank the absorption or different oral administrations

A

I. Tablets (dissolve in stomach)
2. Enteric coated (dissolve in intestine)
3. Sustained release (slowly throughout the day)