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CBT B3 > Week 2 > Flashcards

Week 2 Flashcards

1
Q

Liver cirrhotic

A

kerusakan sel hepatosit krna kerusakan perlahan2 (kronik), scar tissue ganti sel yg rusak, akhirnya ada blockage dari aliran darah ke hepar

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2
Q

etiology liver cirrhotic

A

chronic liver disease (viral [hep a, hep b], alcohol, non alcohol, cryptogenic)

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3
Q

etiopathogenesis liver cirrhotic

A

hepatosit injury –> inflamasi –> hepatric stella cell activate –> pembentukan myofibroblast –> fibrosis hati –> cirrhosis

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4
Q

mediator in liver cirrhosis inflamation + myofibroblast activation

A

igf-1, tgf,… (blm selsai)

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5
Q

Aliran darah akan terganggu di liver cirrhosis karena..?

A

perisinusoidal space menebal, vena tertekan

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6
Q

Fibrosis progression in liver cells

A

hepatic stellate activation –> mild fibrosis (f1) –> clinically relevant fibrosis (f2) –> advanced fibrosis (f3) –> cirrhosis (f4

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7
Q

Untuk menilai fibrosis/cirrhosis hepar

A

fibroscan, apri, fib-4, hepa score, fibro & forns index

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8
Q

compensated vs decompensated fibrosis in hepar

A

comp/decomp = kriteria klinis
decomp = adanya penimbunan cairan/ascites (bisa responsive –> refractory –> death is likely w/o transplant b4 tipe 2 hrs)
comp = tidak ada ascites
dokternya td jelasin dikit lagi tp jujur g kedengaran sinyanya jelek

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9
Q

liver crihosis criteria untuk parameter, tipe, severity yg umum dipake

A

child turcotte pugh, MELD score

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10
Q

Clinical presentation of liver cirrhosis/portal hypertension

A

ascites, splenomegaly, varisces oesophagus, palmar eritem, spider nevi, atrofi m.temporalis, kuku kuning tipis, gynecomastia, liver flap tremor (asterixis)

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11
Q

hepatic steatosis/fatty liver disease

A
  • can be accompanied with cirrhosis
  • akumulasi trigliserida & other fats di sel hepar
  • non alcoholic, alcoholic, metabolic disfunction
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12
Q

pathogenesis fatty liver disease

A
  • decrease faty acid beta oxidation
  • increased endogenous fatty acid sintesis or delivery to hepar
  • deficient VLDL…?
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13
Q

Diagnosis/DB

A

staetosis (non alchohol, alcohol, metabol) –> cubtype of non alcoholic –> steatohepatitis

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14
Q

Bedanya steatohepatitis dngn steatohepatitis lainnya

A

Dm as risk factor
besar heparnya masih tetap
??
sel digantiin lemak

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15
Q

Hepatitis

A

peradangan pada hati (hepar) krna ada luka di hati

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16
Q

Etiologi Hepatitis

A

virus, obat & toksin (parasetamol, amoksisilin, dkk), autoimun, metabolik, herediter

17
Q

Gejala klinis hepatitis

A

ringan (flu-like) –> berat (fulminant)

ikterik, hepatomegali, low grade fever, sakit kepala, sakit otot & sendi, keluhan perut, urin gelap

18
Q

Lab Hepatitis

A 
Fungsi hati :
integritas sel (GOT/AST, GPT/ALT)
integritas saluran (ALP, y-GT)
fungsi sekresi (bilirubin)
fungsi sintesis (albumin, ChE)
Imunologi : 
antibodi (hepatitis), antigen (ag), Molekuler (RNA/DNA)
19
Q

Virus di Hepatitis

A

Virus Hepatitis A-G tapi F gajelas
yg sering : A,B,C
Other : Mumps, Rubella, CMV, Epstein barr

20
Q

Hepatitis A virus

A

4 weeks udah ada IgM/IgG anti-HAV

-poin2 lain ini ga komplit

21
Q

Hepatitis B virus

A

penularan melalui darah and cairan biologis
gejala akut mirip HAV tapi perjalanannya kronik
bagi anak sangat kronis

22
Q

Hepatitis C virus

A

RNA virus
penularan dari darah
insidensi kronis tinggi, risiko parut hepar –> cirrhosis –> kanker
pengobatan interferon and anti-retroviral (tp blm ad yg spesifik c bngt)
labnya fluktuatif

23
Q

HDV

A

mirip B

sth sth

24
Q

HEV

A

RNA virus, non envelope, mirip A, enteric

25
Q

HGV

A

sangat infeksius, mirip C

26
Q

Pankreatitis

A

peradangan pankreas

akut or kronis

27
Q

gejala pankreatitis

A

nyeri lambung bagian atas,

nausea dan vomitus

28
Q

Etiologi pankreatitis akut

A

Penyebab banyak = batu empedu & alkohol. Lain: trauma, tumor, obat/toksin, infeksi (mumps/ parotitis, Coxsackie virus, CMV, HSV, Varicella-Zoster)

29
Q

lab test akut pankreatitis

A

amilase & lipase. Seroimunologi mumps jarang, pemantauan autoimun diabetes (IL-6, anti insulin, anti GAD)

30
Q

etiologi kronis pankreatitis

A

kalsifikasi (alkohol, merokok,
malnutrisi), obstruksi (striktur, tumor), autoimun (responsif
terhadap steroid)

31
Q

lab test kronik pankreatitis

A

Pemeriksaan Amilase & Lipase terdeteksi rendah, insufisiensi eksokrin pankreas
CFA (coefficient of fat absorption), acid steatocrit, fecal elastase-1, mixed triglyceride breath test, fecal chymotrypsin

CBT B3 (3 decks)

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