Week 14 MOAs

Question 1

Digoxin

Answer 1

• positive inotropic actions

- inhibits NaK ATPase pump, increasing Ca in the myocytes changing the electric activity of the heart

Question 2

dopamine

Answer 2

acts on beta adrenoreceptors to cause release of norepinephrine from sympathetic nerve endings

increases HR and contractile force

Question 3

quinidine

Answer 3

blocks sodium channels

• slows impulse conduction, delays repolarization.
• blocks vagal input to heart, widens QRS, prolongs QT

Question 4

lidocaine

Answer 4

accelerates repolarization

Question 5

amiodarone

Answer 5

blocks potassium channel, delaying repolarization

• reduces automaticity of AV node, contractility, contraction velocity
• widens QRS, prolongs PR, QT interval

Question 6

adenosine

Answer 6

-short half life

Question 7

nitroglycerin

Answer 7

acts directly on vascular smooth muscle to promote dilation of veins

• decreases cardiac oxygen demand, reducing pain
• relaxes and prevents spasm in coronary arteries