WEEK 14 - Gastritis, GERD, PUD

Question 1

Pharm Goal of Antacids

Answer 1

Provide immediate relief from symptoms

Question 2

Pharm Goal of Proton Pump Inhibitor (PPI) and H2 receptor blockers

Answer 2

Promote healing of ulcers

Question 3

Pharm Goal of Triple Drug Therapy

Answer 3

Eradicate helicobacter pylori and prevent recurrence of the disease

Question 4

MOA and Indication

Answer 4

PPI: binds irreversibly to proton pump in the gastric parietal cells which result in a reduced gastric acid secretion
H2 blockers: blocks h2 receptors in the gastric parietal cells which results in a reduced gastric acid secretion

Indication (PPI+h2 blocker): reduce gastric acid secretion in patient with GERD, gastritis, PUD

Antacids: neutralize gastric acid
Indication: relieve pain and prevent further damage to mucosa in GERD, gastritis, PUD

Question 5

Side effects of PPI and H2 receptor blocker

Answer 5

Headache
Abdominal pain
Nausea
Diarrhoea
Drowsiness

PPI: Vitamin B12 deficiency
(long term)
H2 receptor blocker: confusion in elderly

Question 6

side effects of antacids

Answer 6

Calcium & Aluminum :
Constipation, nausea,
stomach cramps, flatulence
Magnesium : Diarrhoea,
nausea, vomiting, abdominal
cramping
Sodium :fluid retention,
hypernatremia

Question 7

why is PPI preferred

Answer 7

PPI’s low potential for drug-drug interactions is an advantage as the drug can be used in combination with other ulcer medications without having to separate administration timings

Question 8

simethicone

Answer 8

is an antiflatulent that reduces gas bubbles, antacids containing simethicone decreases the amount of gas associated with bloating and discomfort

Question 9

why is ppi preferred over h2 receptos blockers

Answer 9

ppi reduce gastric acid secretion to a greater extent than the h2 blockers and have a longer duration of action

Question 10

why is cimetidine used less frequently than other h2 blockers

Answer 10

because cimetidine inhibits hepatic drug-metabolizing enzymes, resulting in numerous drug drug interactions and must be taken up to 4 times a day

Question 11

mylanta

Answer 11

is an alternative antacid that can be given if patient feels bloated, simethicone decreases the amount of gas associated with bloating and discomfort

Question 12

what is triple drug therapy

Answer 12

2 antibiotics + 1 PPI
first line 7-10 days
second line 10-14 days