Week 12 Opioids Flashcards
Leading cause of accidental death
Opioid drug overdose
Any substance that activates the mu- opioid receptor
Opioid
Opioids can be 3 things
Syntethic
Semi senthetic
Naturally occurring
What 3 characteristics make heroine highly addictive
Short half life
Rapid
Potent
Is opioid withdrawal fatal?
No
How can opioid withdrawal be fatal
Poorly treated withdrawal can result with patients leaving treatment and dying
Opioid intoxication
A cute - pinpoint pupils, dry mouth, intensity (lower dose) nodding out (high dose) , pale skin, depressed respiration’s, euphoria
Long term- weight loss, malnutrition, poor hygiene, constipation, urinary hesitantancy, scarring
Opioid withdrawal
7-14 days
Protracted 6 months or longer
Tachycardia, sweats, dysphoria, insomnia, pain, dialated pupils, runny nose, agitation, nausea, tremors, yawning, goose flesh skin, drug craving
Suboxone has both
Naloxone - opioid antagonist
Buprenorphrine- opioid partial agonist
Difference between buprenophrine and methodone
Buprenorphrine- opioid partial agonist
Methadone- opioid full agonist
What two things is tramadol
Weak mu-receptor agonist
Has snri properties
How many half lives does it take to clear a substance from the body
Takes 5 half lives to get to steady state and to clear out of system