Week 12 cont: GI Flashcards

1
Q

Clarithromycin // Amoxicillin // Bismuth // Metronidazole // Tinidazole // Tretracycline: Class, Indication, MoA (2), AE (2)

A

Class: Antibiotics
Indication: PUD due to H. pylori
MoA:
- CANNOT be given alone, give with antisec agent
- Targets bacteria
AE:
- Increased risk of bacterial resistance (if given alone)
- -azoles: Disulfram-like reaction with alcohol

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2
Q

Cimetidine // Famotidine: Class (2), Administration, Indication, MoA (2), AE (3), Interactions (2)

A

Class:
- H2 receptor antagonist
- Antisecretory agent
Administration: PO, large Vd (including BBB)
Indication: PUD
MoA:
- Block H2 receptor in stomach
- Decreased gastric acid secretion
AE (RARE):
- Anti-androgenic: gynecomastia, impotence
- CNS effects: confusion, hallucinations, depression/excitation
- Pneumonia
Interactions
- CYP450 inhibitors
- Antiacids decrease absorption of cimetidine

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3
Q

Omeprazole // Iansoprazole // Pantoprazole: Class (2), Indication, MoA (2), AE (5), Interaction (1)

A

Class:
- Proton pump inhibitor
- Antisecretory agent
Indication: PUD
MoA:
- Prodrug
- Irreversible inhibition of H+/K+ ATPase
AE:
- Minor: HA, N/V, dirrhea
- Pneumonia
- Long term + high dose → fractures
- Rebound acid hypersecretion
- HypoMg2+
Interaction: Decreased absorption of some HIV drugs + antifungals

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4
Q

Antiacids: Indication, MoA (2), Contraindications (2)

A

Indication: PUD
MoA:
- Alkaline compounds neutralize stomach acid
- Minimal systemic absorption
Contraindications:
- Severe renal disease
- Heart failure

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5
Q

Sucralfate: Class, Administration, Indication, MoA (2), AE (1), Interaction

A

Class: Increases defensive factors
Administration: PO
Indication: PUD
MoA:
- In low pH, polymerization of drug occurs
- Sticky gel over ulcer
AE: Minimal constipation
Interaction: May decrease absorption of other drugs (give 2hr apart)

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6
Q

Misoprostol: Class (2), Indication, MoA (3), AE (3), Contraindication

A

Class:
- Increases defensive factors
- Prostaglandin E1 analog* Direct replacement for NSAIDs that inhibit PG
Indication: PUD
MoA:
- Suppresses gastric acid secretion
- Promotes secretion of bicarbonate + mucus
- Maintains submucosal blood flow
AE:
- Dose-related diarrhea
- Abdominal pain
- Spotting/dysmenorrhea
Contraindication: Pregnancy

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7
Q

Psyllium: Class (2), Indications (2), MoA (2), AE

A

Class:
- Bulk-forming laxative
- Type 3: slow → soft, formed stool
Indications:
- Constipation
- Diarrhea
MoA:
- Swell in water → increase in stool bulk
- Stretching of intestinal wall → peristalsis
AE: Minimal

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8
Q

Docusate: Class (2), Indication, MoA (2), AE

A

Class:
- Surfactant laxative (stool softener)
- Type 3: slow → soft, formed stool
MoA:
- Lower surface tension of stool = facilitation of H2O entry
- May also stimulate H2O + electrolyte secretion into intestinal lumen
AE: Minimal

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9
Q

Bisacodyl // Senna: Class (2), Administration (2), Indication, MoA (2), AE (1)

A

Class:
- Stimulant laxative
- Type 2: Intermediate → semifluid stool
Administration:
- PO
- PR (more rapid)
MoA:
- Stimulate intestinal motility
- Increase H2O + electrolyte secretion into intestinal lumen
AE: Cramping

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10
Q

Mg compounds // Polyethylene glycol // Lactulose: Class (2), Indication (2), MoA (2), AE (4)

A

Class:
- Osmotic laxative
- Type 1/2: rapid/intermediate → watery/semi-fluid stool
Indication:
- Constipation
- Lactulose: liver cirrhosis symptoms
MoA:
- Poorly absorbed compounds draw water into the intestinal lumen
- Increase fecal mass and peristalsis
AE:
- Dehydration
- Bloating
- Cramping
- Flatulence

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11
Q

Methylnaltrexone: Class, Indication, MoA (2)

A

Class: Opioid antagonist (selective mu)
Indication: Constipation
MoA:
- Blocks mu receptors on the GI tract
- Increases peristalsis

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12
Q

Ondansetron: Class, Administration, Indication, MoA, AE (4)

A

Class: Serotonin receptor antagonist
Administration: PO/IV
Indication: Antiemetic
MoA: Block 5-HT3 of CTZ and afferent GI neurons
AE:
- Headache
- Dizziness
- Diarrhea
- QT prolongation

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13
Q

Dexmethazone: Class, Administration, Indication, AE (2)

A

Class: Glucocorticoid
Administration: IV
Indication: Antiemetic
AE:
- No serious AE due to short duration
- Can see transient blood glucose increase

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14
Q

Aprepitant: Class, Administration, Indication, MoA, AE, Contraindications (2)

A

Class: SubP/NK1 receptor antagonist
Administration: PO
Indication: Antiemetic (cancer nausea prevention)
MoA: Block NK1 receptors in CTZ
AE: Well tolerated (some fatigue + dizziness)
Contraindications:
- Inhibits one family of CYP450, induces another
- Increase metabolism of warfarin and OCs

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15
Q

Phenothiazine (Promethazine): Class, Indication, MoA, AE (5), Contraindication

A

Class: Dopamine antagonist
Indication: Antiemetic
MoA: Block DA2 receptors in CTZ
AE:
- Hypotension
- Sedation
- Respiratory depression
- EPS
- Tissue injury with extravasion
Contraindication: <2yr

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16
Q

Butyrophenone (Haloperidol): Class, Indication, MoA, AE (6)

A

Class: Dopamine antagonist
Indication: Antiemetic
MoA: Block DA2 receptors in CTZ
AE:
- Hypotension
- Sedation
- Respiratory depression
- EPS
- Tissue injury with extravasion
- QT prolongation

17
Q

Cannabinoids: Indications (2), MoA, AE (5)

A

Indications:
- Antiemetic
- Appetite stimulation in AIDS patients
MoA: Unknown (maybe agonism of cannabinoid receptors in vomiting center)
AE:
- Tachycardia
- Hypotension
- Drowsiness
- Abuse potential
- Caution with psych disease

18
Q

Scopolamine: Class, Administration, Indication, MoA (2), AE (4)

A

Class: Muscarinic receptor
Administration: PO, SQ, transdermal
Indication: Antiemetic (prophylactically)
MoA:
- Block M receptors
- Decrease transmission from inner ear to vomiting center
AE:
- Dry mouth
- Blurry vision
- Drowsiness
- Urinary retention, constipation, disorientation (rare)

19
Q

Meclizine: Class (2), Indication, MoA (2), AE (5)

A

Class:
- Antihistamine
- Muscarinic + histamine receptor antagonist
Indication: Antiemetic
MoA:
- Block M + H receptors
- Decrease transmission from inner eat to vomiting center
AE:
- Sedation
- Dry mouth
- Blurry vision
- Urinary retention
- Constipation

20
Q

Lopramide: Class, Indication, MoA (4)

A

Class: Opioid
Indication: Nonspecific antidiarrheal
MoA:
- Activate opioid receptors
- Decreased bowel motility
- Allows for increased time for absorption of H2O and electrolytes
- COMBINE WITH OTHER DRUGS with unpleasant side effects to prevent abuse

21
Q

Alosteron: Administration, Indication, MoA (3), AE (1), Contraindications (3)

A

Administration: PO, CYP450 metabolism
Indication: IBS-D in women
MoA:
-5-HT3 specific block
- Decreased abdominal pain
Increased colonic transit time
AE: Well tolerated, severe AE due to ischemic colitis
Contraindications:
- GI obstruction
- Constipation
- GI perforation

22
Q

Sulfazalazine: Class, Indication, MoA (3), AE (4)

A

Class: 5-aminosalicylate
Indication: IBD
MoA:
- Metabolized by intestinal bacteria (5-ASA + sulfrapyridine)
- 5-ASA: suppresses PG synthesis + local inflammation
- Sulfrapyridine: AEs
AEs:
- N/V
- Rash
- Arthralgia
- Rare: agranulocytosis, hemolytic anemia

23
Q

Budesonide: Class, Administration, Indication, MoA (2)

A

Class: Glucocorticoid
Administration: PO or IV
Indication: IBD (not long-term)
MoA:
- Releases drug when it reaches ileum and ascending colon
- Results in higher concentration where it’s needed with lower systemic effects (decreased inflammation)

24
Q

Azathioprine // Cyclosporine // Methotrexate: Class, Indication, MoA, AE (3)

A

Class: Immunosuppressants
Indication: IBD (long-term)
MoA: Suppress immune response
AE:
- Bone marrow suppression, pancreatitis
- Renal impairement
- Neurotoxicity

25
Q

Infliximab: Class (2), Administration, Indication, MoA, AE (2)

A

Class:
- Immunomodulator
- Tumor necrosis factor inhibitor
Administration: IV ONLY
Indication: IBD (2nd line)
MoA: Monoclonal antibodies that modulate immune response
AE:
- Infections
- Infusion reactions

26
Q

Metoclopramide: Class, Indications (4), MoA (2), AE (3), Contraindications (3)

A

Class: Dopamine antagonist
Indications:
- GERD
- Chemo-induced N/V
- DM gastroparesis
- Antiemetic AND prokinetic
MoA:
- Block DA2 + 5-HT receptors in CTZ
- Increase upper GI tone/motility via ACh enhancing
AE:
- Sedation
- Diarrhea
- Long-term → EPS
Contraindications:
- GI obstruction
- GI perforation
- Hemorrhage