Week 10: Psychotherapeutics Flashcards

1
Q

Schizophrenia: General pathophysiology (2)

A
  1. Excessive DA receptor activation
  2. Insufficient glutamate receptor activation
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2
Q

Compare and contrast first-generation (conventional) antipsychotics to second-generation (atypical) antipsychotics (4)

A

Both are equally effective
- 1st gen are cheaper than 2nd gen
- 1st gen causes extrapyramidal symptoms (ex. tremors)
- 2nd gen causes metabolic effects and carries risk for CV events + premature death

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3
Q

Extrapyramidal side effects (EPS): 4 types and treatments

A

4 types: Pseudoparkinsonism, acute dystonia, akathisia, and tardive dystonia
Only the first three can be treated with drugs

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4
Q

Neuroleptic malignant syndrome: Symptoms (8) and treatments (2)

A

Symptoms:
- Rigidity
- Sudden high fever
- Sweating
- ANS instability
- BP changes
- Dysrhythmias
- Seizures
- Loss of consciousness
- Coma
Treatment: Supportive measures and withdrawal of antipsychotic med

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5
Q

Main differences between neuroleptic malignant syndrome and serotonin syndrome

A

Cause:
- NMS: Antipsychotic medications
- SS: Drugs that inc. 5-HT

Symptoms:
- NMS: Rigidity, dec. bowel activity, normal pupils
- SS: Tremor/hyperreflexia, hyperactive bowel activity, dilated pupils

Onset and duration:
- NMS: Gradual onset, long duration
- SS: Rapid onset, short duration

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6
Q

Haloperidol: Class, indications, MOA, AE (10)

A

Class: High potency first-generation antipsychotic
Indications: Schizophrenia
MOA: Block dopamine receptors in mesolimbic area of the brain
- May also block ACh, histamine, NE
AE:
- EPS
- Neuroleptic malignant syndrome
- Anticholinergic effects
- Orthostatic hypoTN
- Neuroendocrine effects
- Seizures
- Sexual dysfunction
- Agranulocytosis
- Severe dysrhythmias
- Dermatologic effects

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7
Q

Haloperidol: What’s unique? (3)

A
  • Generally preferred for initial therapy
  • EPS symptoms present earlier
  • Lower frequency of all other AEs
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8
Q

Chlorpromazine: Class, indications, MOA, AE (10)

A

Class: Low potency first-generation antipsychotic
Indications: Schizophrenia
MOA: Block dopamine receptors in mesolimbic area of the brain
- May also block ACh, histamine, NE
AE:
- EPS
- Neuroleptic malignant syndrome
- Anticholinergic effects
- Orthostatic hypoTN
- Neuroendocrine effects
- Seizures
- Sexual dysfunction
- Agranulocytosis
- Severe dysrhythmias
- Dermatologic effects

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9
Q

Second Generation Antipsychotics: Indications, MOA, AE (8)

A

Indications: Schizophrenia
MOA: Blockade of DA, 5-HT receptors
- Also can block a1, histamine, and muscarinic receptors
AE:
- EPS
- Metabolic effects (DM, weight gain, hyperlipidemia)
- Agranulocytosis
- Seizures
- Myocarditis
- Orthostatic hypoTN
- Higher risk mortality w/ dementia
- Avoid drugs that suppress bone marrow

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10
Q

Second-generation antipsychotics: What’s unique? (2)

A
  • Lower EPS but higher metabolic effects
  • Very expensive
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11
Q

Depression: General pathophysiology

A

Deficiency of NE, 5-HT, or both

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12
Q

Fluoxetine: Class, indications, MOA, AE (8), drug interactions (9)

A

Class: SSRI
Indications: Depression and/or anxiety
MOA: Blocks reuptake of 5-HT = inc. serotonin available
AE:
- Nausea
- Agitation/insomnia
- Sexual dysfunction
- Weight gain
- Dec. platelet aggregation
- Serotonin syndrome risk
- Withdrawal syndrome with abrupt discontinuation
- In late pregnancy: Withdrawal and pulmonary HTN in newborn
Drug interactions:
- Inc. risk of serotonin syndrome: MAOIs, SNRIs, TCAs, analgesics, triptan antimigraine drugs
- Tramadol
- Linezolid (antibiotic that inhibits MAO)
- Inc. bleeding risk: Antiplatelets and Anticoagulants

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13
Q

Venlafaxine: Class, indications, MOA, AE (8), drug interactions (9)

A

Class: SNRI
Indications: Depression and anxiety
MOA: Blocks reuptake of 5-HT and NE = inc. serotonin and NE available
AE:
- Nausea
- Agitation/insomnia
- Sexual dysfunction
- Weight gain
- Dec. platelet aggregation
- Serotonin syndrome risk
- Withdrawal syndrome with abrupt discontinuation
- In late pregnancy: Withdrawal and pulmonary HTN in newborn
Drug interactions:
- Inc. risk of serotonin syndrome: MAOIs, SSRIs, TCAs, analgesics, triptan antimigraine drugs
- Tramadol
- Linezolid (antibiotic that inhibits MAO)
- Inc. bleeding risk: Antiplatelets and Anticoagulants

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14
Q

SNRIs vs SSRIs

A
  • SSRIs are safer
  • SNRIs have more AEs, especially dose-related HTN
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15
Q

Amitriptyline: Class, indications, MOA, AE (6), drug interactions (4)

A

Class: TCA
Indications: Depression, anxiety, and BPD
MOA: Block the reuptake of 5-HT, NE, and acetylcholine = inc. serotonin, NE, and acetylcholine available
- Not very selective, can also impact other receptors
AE:
- Orthostatic hypoTN
- Anticholinergic effects
- Sedation
- Cardiac toxicity
- Seizure risk
- Toxicity = dysrhythmias, heart block
Drug interactions:
- MAOIs = severe HTN risk
- Direct acting sympathomimetics = HTN/tachycardia risk
- Indirect acting sympathomimetics = dec. responsiveness
- CNS depressants = additive effect

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16
Q

MAOIs, nonselective: Indications, MOA, AE (2), drug interactions (6)

A

Indications: Depression and anxiety
MOA: Inhibition of MAO
- Inc. of available NE, 5-HT, DA
AE:
- CNS stimulation
- Orthostatic hypoTN
Drug interactions:
- Indirect acting sympathomimetics = HTN
crisis
- MAO inhibition = increased epi, NE, DA. Intensified/prolonged effects!
- TCAs = HTN crisis
- Serotonergic drugs = serotonin syndrome risk
- Antihypertensives = hypotension
- Meperidine = hyperpyrexia risk

17
Q

MAOIs, MAO-B selective: Indications, MOA, AE (2)

A

Indications: Depression and anxiety
MOA: Inhibition of MAO-B
- Inc. of available DA
AE:
- CNS stimulation
- Orthostatic hypoTN

18
Q

MAOIs: What’s unique?

A

All drugs in current use are IRREVERSIBLE, effects persist 2 weeks

19
Q

Buproprion: Class, indications, MOA, AE (6)

A

Class: Atypical antidepressants
Indications: Depression and anxiety
MOA: Unclear, may be due to DA/NE reuptake block
AE:
- Agitation
- Tremor
- Insomnia
- Seizures in high doses
- Weight loss
- GI upset, constipation

20
Q

Bipolar disorder: General pathophysiology

A

Disruption of neuronal growth

21
Q

Bipolar disorder: General considerations for treatment (3)

A

Acute mania = Mood stabilizer +/- SGA. May also require benzo
Acute depression = Mood stabilizer +/- SGA +/- antidepressant (never antidepressant alone)
Long-term preventative treatment = 1+ mood stabilizer

22
Q

Lithium: Class, indications, MOA, AE (9), drug interactions (4), PK (2)

A

Class: Mood stabilizer
Indications: BPD
MOA: Unknown, may be alteration of glutamate uptake/release, 5-HT antagonism, and/or glycogen synthase kinase03 beta inhibition
AE:
- N/V
- Diarrhea
- Thirst, polyuria
- Lethargy
- Slurred speech
- Fine hand tremor
- Renal toxicity
- Hypothyroidism + goiter
- Teratogenesis
Drug interactions:
- Diuretics
- NSAIDS inc. lithium plasma levels
- Anticholinergics
- ACE inhibitors
PK:
- Short half-life, must be administered multiple times per day
- Caution in renal disease

23
Q

Lithium: Therapeutic index

A

Very low therapeutic index - must monitor drug levels

Toxicity/overdose = No antidote, supportive treatment, may consider hemodialysis

24
Q

Valproate // Carbamazepine: Class, indications, MOA

A

Class: Antiepileptic drugs
Indications: BPD
MOA: Neurotrophic and neuroprotective effects

25
Q

Benzodiazepines: Indications, MOA, AE (5)

A

Indications: Insomnia
MOA: GABA potentiation
AE:
- CNS depression
- Anterograde amnesia
- Can have paradoxical effects
- Teratogenic
- PO dosing: Minimal respiratory depression, minimal CV effects

26
Q

Zolpidem: Class, indications, MOA, AE (2)

A

Class: Benzodiazepine-like drugs
Indications: Insomnia
MOA: Acts as agonist at GABA receptor
AE:
- Similar to benzos
- Little to no respiratory depression at therapeutic doses

27
Q

Ramelteon: Class, indications, MOA, AE

A

Class: Melatonin agonist
Indications: Insomnia
MOA: Melatonin agonist
AE: Nothing notable

28
Q

Suvorexant: Class, indications, MOA, AE (5)

A

Class: Orexin antagonist
Indications: Insomnia
MOA: Antagonizes orexin
AE:
- Somnolence, dizziness
- HA
- Dry mouth
- Cough
- Physical dependence

29
Q

Barbituates: Indications, MOA, AE (5)

A

Indications: Insomnia
MOA: Agonize GABA receptors directly
AE:
- Respiratory depression
- Sedation
- Minimal CV effects at hypnotic doses
- CYP450 induction
- Physical dependence

30
Q

Buspirone: Indications, MOA, AE (3)

A

Indications: Anxiety
MOA: Binds to 5-HT receptors, less so to DA receptors
AE: Minimal
- Dizziness
- Nausea
- Headache

31
Q

Buspirone: What’s unique?

A

As effective as benzos, but no abuse potential/CNS depressant interactions

32
Q

Panic disorder: Definition and treatments (2)

A

Definition: Recurrent, intensely uncomfortable episodes
Treatments:
- Antidepressants (SSRIs,
TCAs)
- Benzodiazepines (2nd
line)

33
Q

OCD: Definition and treatments (3)

A

Definition: Persistent obsessions & compulsions that cause marked distress
Treatments:
- SSRIs
- One TCA
- Last resort: deep brain
stimulation

34
Q

Social anxiety disorder: Definition and treatments (3)

A

Definition: Intense, irrational fear of situations in which one might be scrutinized by others
Treatments:
- SSRIs (first line)
- Benzodiazepines
- Propranolol or other BB for
performance anxiety

35
Q

PTSD: Definition and treatments (3)

A

Definition: After a traumatic event that elicited reaction of fear, helplessness, or horror
Treatments:
- SSRIs/SNRIs (only paroxetine & sertraline are approved for this)
- TCA/MAOI (2nd line)
- Psychotherapy

36
Q

ADHD: General pathophysiology (3)

A
  • Structural and functional abnormalities in multiple areas of the brain
  • May involve dysregulation of NE, DA, 5-HT pathways
  • Genetic factors
37
Q

Amphetamines: Indications, MOA, AE (6)

A

Indications: ADHD
MOA: Causes release of NE and DA
- Partially inhibits their reuptake
AE:
- CNS: Insomnia, restlessness, euphoria, talkativeness, appetite suppression
- CV: Tachycardia, inc. contractility, vasoconstriction = dysrhythmias, HTN
- Psychosis with excessive use

38
Q

Methylxanthines: Indications, MOA, AE (9)

A

Indications: ADHD
MOA: Reversible adenosine receptor block
- Inc. SR Ca2+ permeability
- cAMP accumulation
AE:
- CNS: Nervousness, insomnia, tremors
- CV: Tachycardia, dysrhythmias, peripheral vasodilation, CNS vasoconstriction
- Bronchodilation
- Diuresis

39
Q

Modafinil: Indications, MOA, AE (5)

A

Indications: ADHD
MOA: Unclear, influences hypothalamic areas involved in maintaining areas involved in maintaining sleep/wake cycles
AE:
- Headache
- Nervousness
- Nausea
- Diarrhea
- Rare skin interactions