week 12

Question 1

what class of drug is salbutamol?

Answer 1

Selective B2 adrenergic receptor agonist
Short acting B2 agonist (SABA)

Question 2

mechanism of action of salbutamol?

Answer 2

stimulation of B2 receptor on bronchi smooth muscle.
activates adenylate cyclase.
increase cAMP causing smooth muscle relaxation.
Also activation of Na/K/ATPase - shift in K

Question 3

how is tachycardia caused by salbutamol?

Answer 3

Saturation of B2 receptors at high doses causes B1 effects eg tachycardia.

Question 4

What class of drug is ipratropium bromide?

Answer 4

anticholinergic bronchodilator.
muscuranic receptor anatagonist (MRA).
Quarternary structure.

Question 5

mechanism of action ipratropium bromide?

Answer 5

Blocks muscuranic M3 receptors on bronchi smooth muscle.
Inhibits acetylcholine mediated bronchoconstriction.
reduces mucus absorption.

Question 6

why does ipratropium not cross the blood brain barrier.

Answer 6

Quarternary ammonium compound

Question 7

when should you use ipratropium with caution?

Answer 7

Narrow angle glaucoma.
Prostatic hypertrophy.
Urinary retention.
Pregnancy.