Week 11 The respiratory system (introduction & respiratory strategies Flashcards
What is air made of?
Air = mixture of gases Nitrogen (78%), Oxygen (21%), Argon (0.9%), Carbon dioxide (0.03%)
What does Dalton’s law dictate?
– In a gas mixture, each gas exerts its own partial pressure (PP)
– The sum of PPs of all gases in a mixture gives total pressure
– PP of a gas is proportional to the number of gas molecules
Calculate the PP of O2 in environment at sea level.
– atmospheric pressure = 760 mmHg (might be given might not, good to know)
21% is Oxygen of that total
-0.21 x 760= 160 mmHg
Calculate the PP of O2 in environment at 18,000 ft
– atmospheric pressure = 380mmHg (would be given)
- 0.21 x 380 mmHg= 80mmHg
How does atmospheric pressure change with altitude and how does that affect biological organisms? give examples.
With increasing altitude, atmospheric pressure ↓ (decreases)
• air becomes thinner at higher altitudes
• summit of Everest - air has 1/3 of the O2 content per unit volume
– Humans – cant survive high altitudes > only few hrs without supplemental O2
– Many other animals reach higher altitudes with no ill effects
– E.g. pikas (genus Ochotona), jumping spiders (family Salticidae)
What adaptations do animals that live in high altitude regions have?
– Able to extract O2 more efficiently from air
– Can tolerate low blood O2
– Can tolerate changes in blood CO2 & pH
Why is oxygen necessary for life?
– animals depend on cellular respiration to supply ATP
– mitochondria oxidise nutrients → produce ATP
– consume O2 & produce CO2
= must obtain O2 from environment & dispose of CO2 to meet metabolic needs
What is cellular respiration?
– process by which mitochondria consume O2 and produce CO2
What is external respiration?
– sequence of events associated with exchange of O2 & CO2 between external environment & mitochondria within cells
– mitochondria consume O2 & ↓ local O2 concentration
=concentration gradient – low O2 in cell, high O2 in blood
How do Unicellular organisms & small organisms (aquatic environments) perform external respiration?
• utilize diffusion gradient – drives gas exchange with environment
How do larger animals perform external respiration?
• diffusion & bulk flow used to obtain O2 from environment & deliver to cells
- utilise diffusion to transport gases across short distances
- utilise bulk flow to transport gases over long distances
What are the steps of external respiration?
(x 4 steps)
1. Ventilation (bulk flow)
– respiratory medium (air/water) moved across respiratory surface
2. Exchange of O2 & CO2
– exchange between respiratory surface & blood
3. Transport of O2 & CO2 (bulk flow)
– transport between respiratory surface/blood interface & tissues by CS
4. Exchange of O2 & CO2
– exchange between blood & tissues across systemic capillaries
What is the formula for rate of diffusion? (alternatively what is rate of diffusion?)
-Fick’s law of diffusion dQ/dt = D x A x (dC/dx)
What are Factors that influence rate of diffusion?
– Diffusion coefficient (D)
• index of ease of diffusion of particular substance through given medium
– Area of the membrane (A)
– Concentration or energy gradient (dC/dx or ∆Pgas)
• difference in concentration per unit distance – energy gradient
• when applied to gases the energy gradient - pressure difference
What are Factors that influence diffusion when gases dissolved in liquids ?
– gas solubility (proportional)
– molecular weight (indirectly proportional)