Week 10-Repro Flashcards
Gluteus maximus:
Action?
Innervation?
- action: keeps knee fully extended, hip extension, lateral rotation of the hip, abduction of the hip
- innervation: inferior gluteal nerve
Gluteus medius:
Action?
Innervation?
- action: hip extension, lateral rotation of the hip, abduction of the hip*, prevents hip drop
- innervation: superior gluteal nerve
Gluteus minimus:
Action?
Innervation?
- action: hip flexion, medial rotation of the hip, abduction of the hip, prevents hip drop
- innervation: superior gluteal nerve
Tensor fascia latae:
Action?
Innervation?
- action: keeps knee fully extended, hip flexion, medial rotation of the hip, abduction of the hip
- innervation: superior gluteal nerve
What is IT band syndrome?
IT band runs over the lateral condyle of the femur causing pain, often seen in runners
What are the lateral rotators of the hip, from superior to inferior?
- piriformis
- gemellus superior
- obturator internus
- gemellus inferior
- quadratus femoris
Where does the sciatic nerve run in relation to the lateral rotators of the hip?
between the piriformis and gemellus superior
What is piriformis syndrome?
tightening of the piriformis can compress the sciatic nerve
What muscle runs between the superior and inferior gluteal nerves?
the piriformis
What are the boundaries of the perineum?
pubic symphysis, coccyx, and ischial tuberosities
What triangles form the peirneum?
the anal (posterior) and urogenital (anterior)
What are the boundaries of the anal triangle?
What is contained within it?
- the ischial tuberosities and the coccyx
- anal canal and anal sphincters
Why is the pectinate line important?
-it separates visceral from parietal
Above the pectinate line: Vein drainage? Type of nerves? Hemorrhoid classification? Painful? Embryological origin?
- to the portal system
- visceral
- internal, not painful
- endoderm
Below the pectinate line: Vein drainage? Type of nerves? Hemorrhoid classification? Painful? Embryological origin?
- systemically
- somatic
- external, painful
- ectoderm
External anal sphincter:
Type of muscle?
Innervation?
- skeletal muscle
- somatic pudendal nerves
Internal anal sphincter:
Type of muscle?
Innervation?
- smooth muscle
- visceral involuntary nerves
What are the boundaries of the ischiorectal fossa?
What does it contain?
- lateral wall: obturator fascia and pudendal canal
- roof: pelvic diaphragm
- medial wall: external anal sphincter
- floor: skin
- fat and inferior rectal nerve, artery, and vein
Superficial uritogenital pouch:
Boundaries?
Contents in males?
Contents in females?
- superficial perineal fascia (Colle’s) and the perineal membrane
- males: ischiocavernous muscles, bulbospongiosus muscle, superficial transverse perineal muscles, crura and bulb of penis
- females: ischiocavernosus muscles, bulbospongiosus muscle, superficial transverse perineal muscles, crura of the clitoris, bulbs of vestibule, greater vestibular glands (Bartholin’s)
Deep uritogenital pouch:
Boundaries?
Contents in females?
In males?
- pelvic diaphragm and perineal membrane
- females: sphincter muscles, urethra, vagina
- males: sphincter muscles, bulbourethral gland (Cowper’s), membranous part of urethra
Why is the perineal body important?
it is the anchoring point for many muscles, therefore important for maintaining perineal tone and support to the pelvic organs
What things make up the root of the penis?
the crura and the bulb
What binds together the erectile bodies and vessels of the penis?
the deep penile fascia (Buck’s)
Describe the fundiform ligament.
it is a remnant of Scarpa’s fascia that forms a sling around the penis to suspend it
What is the pudendal canal?
What runs through it?
- a sleeve of obturator fascia
- the pudendal nerve and internal pudendal vessels
What is the major nerve of the perineum?
the pudendal nerve
How do S2-3 leave the pelvis?
the greater sciatic foramen
Describe the course of the pudendal nerve.
- passes out of the pelvic cavity through the greater sciatic foramen
What does the deep dorsal vein of the penis drain into?
the prostatic plexus
What does the deep dorsal vein of the clitoris drain into?
the vesical venous plexus
What is the function of the testis?
- spermatogenesis (in seminiferous tubules)
- testosterone production
What is the function of the epididymis and vas deferens?
- sperm maturation and storage
- exit route for sperm from the testis
What is the function of the seminal vesicle?
- supplies bulk of semen volume
- supplies fructose to seminal plasma
- secretes prostaglandins for sperm motility
- supplies precursors for semen clotting
What is the function of the ejaculatory duct?
-links the vas deferens and seminal vesicles to the urethra
What is the function of the bulbourethral glands?
-secretes mucous for lubrication
What is the function of the penis?
- erection and ejaculation
- urinary conduit
What is the general structure of the testis?
it is divided into about 250 lobules by septae, with each lobule containing 1-4 seminiferous tubules
Where do Sertoli cells live in relation to the seminiferous tubules?
Leydig cells?
- Sertoli cells live inside the seminiferous tubules
- Leydig cells live outside the seminiferous tubules
How long does spermatogenesis take to occur?
Each phase?
- 74 days overall
- 50 days in the testis, 24 days in the epididymis
In the sperm, what does the neck contain?
The principal/middle piece?
The tail?
- neck: centrioles
- principal/middle: mitochondria
- tail: flagella
What are the functions of Sertoli cells?
- support attachment of spermatogenetic cells
- nutrition of sperm
- secrete androgen binding peptide (ABP), inhibin, plasminogen activator, transferrin, and ceruloplasmin
- phagocytosis of residual bodies
- create tight Sertoli-Sertoli cell junctions to form the blood-testis barrier
What do Sertoli cells look like?
What is a prominent feature?
- tall columnar cells
- they have a prominent nucleolus
Why is the blood-testis barrier important?
it shelters the foreign haploid sperm from the immune system
What is the function of androgen binding peptide (ABP)?
What secretes it?
- it allows for concentration of testosterone
- Sertoli cells
Leydig Cells: What is their general function? What do they do during embryonic development? During puberty? During adulthood?
- secrete steroids, mainly testosterone
- embryo: testosterone helps develop the male gonads
- puberty: testosterone initiates spermatogenesis, accessory sex gland secretion, secondary sex characteristics
- adulthood: maintains spermatogenesis and secondary sex characteristics
What is the function of LH in males?
it tells Leydig cells to secrete testosterone
What is the function of FSH in males?
it tells Sertoli cells to make ABP in order to concentrate testosterone at the site of spermatogenesis
In reproductive years in males, do you have more LH or FSH produced?
more LH as compared to FSH
What converts androgens to estrogen?
Where is it found in males?
- aromatase
- seminiferous tubules and fat
What converts testosterone to DHT?
Where is it found?
- 5a-reductase
- hair, external genetalia, and prostate gland
What happens to sperm in the epididymis?
Why does the epididymis produce a glycoprotein?
- sperm mature, get transported, get concentrated, and acquire motility
- to inhibit capacitation (don’t want that to happen until inside female)
What is the epithelium of seminal vesicles?
columnar epithelium with secretory granules
What does the prostate secrete?
prostatic acid phosphate (PAP) and prostate specific antigen (PSA)
What is BPH?
What problem can it cause?
How do you therapeutically target it?
- benign prostatic hypertrophy, androgen-dependent growth of stromal and epithelial cells forms nodules
- urinary obstruction
- inhibition of DHT formation or smooth muscle relaxants
What is DHT’s role in prostatic hyperplasia?
How/where is it made?
- it is a potent growth factor
- made in stromal cells that cross-talk with the epithelial cells
What type of erectile tissue surrounds the penile urethra?
the corpus spongiosum
What epithelium do you find in the penile urethra?
pseudostratified columnar epithelium
What epithelium is the glans penis lined by?
squamous epithelium
What is the most important molecule for erection?
Where does it come from?
What is important for terminating an erection?
- nitric oxide
- nitric oxide synthase in parasympathetic nerves and endothelial cells
- alpha adrenergics and PDE5
What are the hormones made by the ovaries responsible for?
- prepare the endometrium for conception
- maintain pregnancy after fertilization
What is the purpose of the stroma in the ovary?
- provides structural support for the developing ova
- with hormonal stimulation, the stroma around the ovum differentiates into hormone producing layers (theca externa and interna)
Outline the difference between primordial follicles, primary, secondary, and mature follicles?
- primordial: oocyte in stroma
- primary: oocyte surrounded by a flat layer of granulosa cells
- secondary: oocyte enveloped by zona pellucida, granulosa cells, theca interna, and theca externa
- mature: a cavity develops in the granulosa cell layer (antrum)
What happens to the corpus luteum of menstruation?
in the absence of hCG, the corpus luteum degenerates into the corpus albicans in 10-12 days
How is the corpus luteum of pregnancy maintained?
the corpus luteum is sustained by paracrine hormones (estrogen and IGF-1) and endocrine hormone (placental hCG, LH, and prolactin)