Week 10 - Lipoprotein Metabolism Flashcards
Cholesterol can be removed from of the body by the kidney.
a) True
b) False
b) False
Cholesterol occupies most of the volume of adipocytes.
a) True
b) False
a) True
The following are characteristics of ———
I. Component of cell and organelle membranes
II. Precursor for steroid hormones
III. Precursor for vitamin D
IV. Precursor for synthesis of bile acids and salts
a) Carbohydrates
b) Cholesterol
c) Enzymes
d) Triglycerides
b) Cholesterol
—-is more hydrophilic than ——.
a) Cholesterol
b) Cholesteryl ester
–a) Cholesterol–is more hydrophilic than —b) Cholesteryl ester—.
Cholesteryl ester is the storage form of cholesterol.
a) True
b) False
a) True
Amphipathic is a molecule containing both hydrophilic and hydrophobic moieties.
a) True
b) False
a) True
Triglycerides are —-whereas phospholipids are ——.
a) Amphiphatic
b) Hydrophobic
c) Hydrophilic
Triglycerides are —b) hydrophobic—whereas phospholipids are —a) amphiphatic—.
Cholesterol could be found
a) Inside the cells
b) Inside, outside, and within the cells
c) Outside the cells
d) Within the cells
b) Inside, outside, and within the cells
The right order of lipoproteins in terms of density from the lowest to the highest is:
a) Chylomicrons – VLDL – IDL – LDL – HDL
b) Chylomicrons – VLDL– LDL – HDL –IDL
c) IDL – VLDL – LDL – HDL – Chylomicrons
d) VLDL – IDL – LDL – HDL – Chylomicrons
a) Chylomicrons – VLDL – IDL – LDL – HDL
The smallest lipoproteins in terms of size is:
a) Chylomicron
b) HDL
c) IDL
d) LDL
e) VLDL
b) HDL
The largest lipoproteins in terms of size is:
a) Chylomicron
b) HDL
c) IDL
d) LDL
e) VLDL
a) Chylomicron
The highest amount of proteins in lipoproteins is in:
a) Chylomicrons
b) HDL
c) IDL
d) LDL
e) VLDL
b) HDL
The highest amount of lipids in lipoproteins is in:
a) Chylomicrons
b) HDL
c) IDL
d) LDL
e) VLDL
a) Chylomicrons
The carrier of lipoprotein is cholesterol:
a) True
b) False
b) False (lipoproteins are the carriers for cholesterol)
Lipoproteins are composed of all the following: o Cholesterol o Phospholipids o Proteins o Triglycerides
a) True
b) False
a) True
Lipoprotein is a component of cholesterol.
a) True
b) False
b) False (cholesterol is a component of lipoproteins)
Lipoproteins are composed of; outer shell of —-, core of fats including —-and a surface —–molecules help tissues to recognize and take up the particles.
a) Apoproteins
b) Cholesterols
c) Phospholipids
Lipoproteins are composed of; outer shell of —-(c)Phospholipids—-, core of fats including —-(b)Cholesterols——-and a surface ——-(a)Apoproteins—molecules help tissues to recognize and take up the particles.
- ————- serve as a vehicle to transport fats and cholesterol in the plasma
a) Carbohydrates
b) Lipoproteins
c) Phospholipids
d) Triglycerides
d) Triglycerides
Apolipoproteins are ———— binding to lipoproteins.
a) Carbohydrates
b) Hormones
c) Proteins
d) Lipids
c) Proteins
The surface of lipoproteins contains the –1—components phospholipids and apolipoproteins, whereas the core contains the –2—components triglycerides and cholesteryl ester.
a) Hydrophilic
b) Hydrophobic
- Hydrophilic
2. Hydrophobic
Binding of LDL to its LDL-receptor is mediated by the apoprotein ——–.
a) Apo A-I
b) Apo A-II
c) APO B 100
d) Apo E
c) APO B 100
Binding of HDL to its receptor ABC1 is mediated by the apoprotein ——–.
a) Apo A-I
b) Apo A-II
c) APO B 100
d) Apo E
b) Apo A-II
One of the functions of —————- is to mediate binding of lipoproteins to lipoproteins receptors.
a) Apolipoproteins
b) Cholesterol
c) HDL
d) LDL
a) Apolipoproteins
One of the functions of —————- is to regulate the metabolism of lipoproteins and their uptake in tissues.
a) Apolipoprotein
b) Lipoprotein receptor
c) Cholesterol
d) HDL
e) LDL
b) Lipoprotein receptor
- ————— is required for synthesis, secretion and catabolism of lipoproteins.
a) Apolipoprotein
b) Cholesterol
c) HDL
d) LDL
a) Apolipoprotein
Elevated LDL and HDL cholesterol increase the risk to get atherosclerosis.
a) True
b) False
b) False
The following factors have a positive impact on increasing the risk to get atherosclerosis.
- High LDL cholesterol
- Diabetes mellitus
- Hypertension
- Smoking
- High triglycerides
a) True
b) False
a) True
Cholesterol is brought to tissues by HDL.
a) True
b) False
b) false
Our body needs —–
a) HDL not LDL
b) HDL and LDL
c) LDL not HDL
b) HDL and LDL
Due to endothelial dysfunction, cholesterol LDL is oxidized and deposited on the blood vessel wall as part of the repair process.
a) HDL
b) LDL
c) VLDL
d) IDL
e) Chylomicron
b) LDL
All LDL are —–cholesterol.
a) Bad
b) Good
c) Good and could be bad
c) Good and could be bad
Cholesterol is needed by many tissues and it is only considered harmful if it is deposited on the blood vessel.
a) True
b) False
a) True
- —– is synthesized by the liver, and —— is synthesized from the GIT.
a) VLDL
b) IDL
c) Chylomicron
d) LDL
e) HDL
a) VLDL
c) Chylomicron
- —-synthesized by the liver and —–synthesized from the GIT will be hydrolysed by lipoprotein lipase to release free fatty acid, which will be uptake by the muscle and adipose tissue.
a) VLDL
b) IDL
c) Chylomicron
d) LDL
e) HDL
a) VLDL
c) Cholymicron
Cells that need lipids (e.g. adipocytes and muscle) will express ———- receptors on its surface.
a) Lipoprotein lipase
b) Cholesterol
c) HDL
d) LDL
a) Lipoprotein lipase
The product of hydrolysis of chylomicron with lipoprotein is —
a) HDL
b) LDL
c) VLDL
d) Chylomicron remnant
e) Cholesterol
d) Chylomicron remnant
A decrease in ———– in a certain tissue stimulates lipoprotein lipase synthesis. Accordingly, more lipoproteins bind to this tissue.
a) Carbohydrate
b) Cholesterol
c) Fatty acids
d) Lipids
e) Protein
b) Cholesterol
Lipoprotein lipase is a glycoprotein that is present on the surface of all cells. Its —-is not good for our health and its —-protect our body against obesity.
a) Excess
b) Deficiency
b) deficiency
a) excess
LPLD is a rare genetic condition that elevates the levels of fat in the blood.
a) True
b) False
a) True
Glybera is the first gene therapy to be licensed in Europe as a remedy for lipoprotein lipase deficiency.
a) True
b) False
a) True
Which tissue/organ can export cholesterol containing lipoprotein particles independent of HDL uptake? I. Adipose tissue II. Liver III. Mammary glands IV. Skeletal muscle Small intestine
a) I and II
b) I and III
c) II and IV
d) II and V
e) III and IV
d) II and V
In the —-lipid cycle, apolipoproteins will make —-from the food in the intestine and will distribute it to tissues through blood. These tissues as skeletal muscles and adipose tissues will produce lipoproteins lipase LPL, which will remove —-from chylomicrons and reduce their size. The remnant chylomicron will be removed by the —.
a) Chylomicrons
b) Cholesterols
c) Exogenous
d) TG
e) Liver
c) Exogenous
a) Chylomicrons
d) TG
e) Liver
In the —-lipid cycle, the —-will produce —-and will transport it through apolipoproteins to the blood stream, where it will be distributed to tissues. These tissues will produce lipoproteins lipase LPL, which will remove triglycerides TG from VLDL and reduce their size to —-then to —-.
a) VLDL
b) IDL
c) Endogenous
d) LDL
e) Liver
c) Endogenous
e) Liver
a) VLDL
b) IDL
d) LDL
Insulin is known to —LPL in —-and its placement in the capillary endothelium. By contrast, insulin has been shown to —-expression of —-LPL. In muscle and myocardial LPL is instead activated by —-and adrenaline.
a) Activate
b) Adipocytes
c) Decrease
d) Glycogen
e) Muscle
a) Activate
b) Adipocytes
c) Decrease
e) Muscle
d) Glycogen
Insulin is known to —-LPL secretion in adipocytes.
a) Activate
b) Deactivate
a) Activate
In case of —-, low insulin doesn’t activate LPL in —-. Accordingly, —–accumulate and deposit in the artery causes —–.
a) Adipocytes
b) Atherosclorosis
c) Diabetes
d) Heart
e) Triglycerides
c) Diabetes
a) Adipocytes
e) Triglycerides
b) Atherosclerosis
Atherosclerosis occurs in case of diabetes, when there is:
a) High insulin and high lipoprotein lipase
b) High insulin and low lipoprotein lipase
c) Low insulin and low lipoprotein lipase
d) Low insulin and high lipoprotein lipase
c) Low insulin and low lipoprotein lipase
- —–mediates binding of LDL to the LDL-receptor.
a) ABCA1
b) Apo B100
c) Apo 48
d) SRB1
e) LCAT
b) Apo B100
----carries ~ 2/3 of Cholesterol in plasma. a) HDL b) LDL c) IDL d) Lipoprotein lipase e) Lipoprotein receptors
b) LDL
Cholesteryl ester is the storage form of cholesterol in the body.
a) True
b) False
a) True
Cholesteryl ester is formed from cholesterol using LCAT.
a) True
b) False
a) True
LDL receptor recognizes VLDL, IDL and LDL through their ——–
a) ABCA1
b) Apo B100
c) Apo 48
d) SRB1
b) Apo B100
Hypercholesterolemia could be regarded to any of the following EXCEPT
a) Mutation in Apo B100
b) Excess production of LDL
c) Mutation in LDL receptor
d) Deficiency in Lipoprotein lipase
d) Deficiency in lipoptotein lipase
Hypercholesterolemia could be regarded to mutation in
a) Apo B100
b) Apo A-I
c) Apo A-II
d) Apo C-III
e) LPL
a) Apo B100
After —-state, we expect to see high chylomicrons in the blood.
a) Fasting
b) Feeding
b) Feeding
In —-state, no chylomicrons is present in the blood.
a) Fasting
b) Feeding
a) Fasting
Hypercholesteremia means high ——
a) Chylomicron
b) HDL
c) IDL
d) LDL
e) VLDL
d) LDL
The enzyme HMG-CoA reductase plays a central role in the production of cholesterol.
a) True
b) False
a) True
- —or HMG-CoA reductase inhibitors are a class of cholesterol lowering drugs that inhibit the enzyme HMG-CoA reductase which plays a central role in the production of —–and prevent cardiovascular disease.
a) Cholesterol
b) Cholesteryl ester
c) Clathrin
d) LPL
e) Statin
e) Statin
a) Cholesterol
In children inulins are effective at reducing cholesterol levels in those withfamilial hypercholesterolemia.
a) True
b) False
b) False
Excess cholesterol in the cells stimulates the liver to synthesise —-.
a) HDL
b) LDL
c) IDL
d) VLDL
e) Lipoprotein lipase
a) HDL
HDL is synthesized by the liver and it picks —– in the cell by interaction with the ATP-binding cassette transporter A1 (ABCA1).
a) Cholesterol
b) Cholesteryl ester
a) Cholesterol
How does cholesterol bind to HDL?
- —— activated ———-which phosphorylates the ABC transporters. Phosphorylation induces a conformational change which permits binding of ATP and opening of the channel for cholesterol to bind to ——.
a) cAMP
b) HDL
c) LDL
d) Protein kinase A
e) Insulin
a) cAMP
d) Protein kinase A
b) HDL
- —————is a protein best known for its role in the direct reverse pathway, facilitating the uptake of Cholesteryl ester-HDL in the —–.
a) CETP
b) Extrahepatic cells
c) Liver
d) LCAT
e) Reverse Scavenger (SR-BI)
e) Reverse Scavenger (SR-BI)
c) Liver
Triglycerides are degraded by hepatic —-so that, finally, small HDL particles are left, which restart the uptake of —– from —.
a) Cholesterol
b) Cholesteryl ester
c) Cells
d) Hydrolase
e) Lipase
e) Lipase
a) Cholestrol
c) cells
In the reverse —-pathway for HDL to get rid of cholesterol, Cholesteryl ester transfer protein (CETP) exchanges —-in VLDL for the —–in HDL.
a) Cholesterol
b) Cholesteryl ester
c) Triglycerides
d) Direct
e) Indirect
e) Indirect
c) Triglycerides
b) cholesteryl ester
In the reverse —-pathway for HDL to get rid of cholesterol, LDL excreted its content of cholesterol to the —–via interacting with its LDL receptors.
a) Kidney
b) Liver
c) Direct
d) Indirect
d) Indirect
b) Liver
The commonly measured lipids in serum are all the following EXCEPT
a) Cholesterol
b) Chylomicron
c) HDL
d) LDL
e) Triglycerides
b) Chylomicron
VLDL-c is estimated to be equal to —— in mmol/L
a) Triglyceride/2
b) Triglyceride/3
c) Triglyceride/4
d) Triglyceride/5
e) Triglyceride/6
d) Triglyceride/5
VLDL-c is estimated to be equal to —— in mg/dL
a) Triglyceride/1.17
b) Triglyceride/2.17
c) Triglyceride/3.17
d) Triglyceride/5
e) Triglyceride/5.17
b) Triglyceride/2.17
Given a serum HDL-C of 0.8 mmol/L, a total cholesterol of 6.0 mmol/L and a Triglyceride of 5.5 mmol/L, what is the most likely calculated LDL-C by the Friedwald formula?
a) 3.0 mmol/L
b) Not valid
c) 4.5 mmol/L
d) 5.0 mmol/L
e) 5.5 mmol/L
b) Not valid
Friedewald equation can estimate the value of
a) Cholesterol
b) HDL
c) LDL
d) Triglycerides
c) LDL
Given a serum HDL-C of 1.5 mmol/L, a total cholesterol of 6.0 mmol/L and a Trigyceride of 1.0 mmol/L, what is the most likely calculated LDL-C by the Friedewald formula?
a) 3.0 mmol/L
b) 4.0 mmol/L
c) 4.5 mmol/L
d) 5.0 mmol/L
e) 5.5 mmol/L
b) 4.0 mmol/L
According to Friedewald equation, the equation is not valid if
a) Cholesterol > 4.5 mmol/L
b) Chylomicron > 4.5 mmol/L
c) HDL > 4.5 mmol/L
d) LDL > 4.5 mmol/L
e) Triglycerides > 4.5 mmol/L
e) Triglycerides > 4.5 mmol/L
The Friedewald formula has the following limitations EXCEPT
a) When chylomicrons are present
b) When plasma TG concentration exceeds 400 mg/dL (4.52 mmol/L)
c) In patients with type III hyperlipoproteinemia
d) When measured in fasting state
d) When measured in fasting state
Hyperlipidemia is measured in the —– state.
a) Feeding
b) Fasting
b) Fasting
Hyperlipidaemias are abnormally elevated levels of any or all——-or———in theblood or both in ————————.
a) Combined hyperlipidaemia
b) Lipids
c) Lipoproteins
b) lipids
c) Lipoproteins
a) Combined hyperlipidaemia
Hyperlipidaemia is the term used due to high concentration of plasma ——-.
a) Cholesterol
b) Chylomicron
c) HDL
d) LDL
e) Triglycerides
e) triglycerides
A disorder in lipoprotein metabolism is considered as a —-cause of hyperlipidemia, whereas, diabetes is considered as a —–cause of hyperlipidemia.
a) Primary
b) Secondary
a) Primary
b) Secondary
A patient with familial hypercholesterolemia could be the result of a deficiency in —-. Thus the cells do not absorb —–and it will be high in plasma.
a) LDL
b) LDL receptor
c) HDL
d) HDL receptor
b) LDL receptor
a) LDL
A patient with familial hypercholesterolemia could be the result of a high synthesis of LDL.
a) True
b) False
a) True
A patient with familial hypercholesterolemia could be the result of a normal synthesis of LDL, but lack of LDL receptors.
a) True
b) False
a) True
A patient with familial hypertriglyceridemia could be the result of a deficiency in —–. Thus the triglycerides won’t get hydrolysed and it will be high in plasma.
a) LDL
b) LDL receptor
c) Lipoprotein lipase
d) HDL receptor
c) Lipoprotein Lipase
A patient with combined ——– has elevated levels of serum cholesterol and triglycerides.
a) Hypercholestrolemia
b) Hyperlipoproteinemia
c) Hyperglycemia
d) Familial hypercholestrlemia
b) Hyperlipoproteinemia
A patient with Tangier disease is expected to have ——–
a) Hypercholestrolemia
b) Hypolipoproteinemia
c) Hyperglycemia
d) Familial hypercholestrlemia
b) Hypoliporoteinemia
A patient with Tangier disease is expected to have absence of the transporter —-, thus, accumulation of cholesterol in the cell, and consequently, low cholesterol and —–in the serum.
a) ABCA1 transporter
b) Cholesterol
c) HDL
a) ABCA1 transporter
c) HDL
Diagnosis of dyslipidemia is dependent upon the measurement of the following EXCEPT:
a) Chylomicron
b) HDL
c) LDL
d) Tg
e) Total cholesterol
a) Chylomircon
