Week 10 - Asthma / COPD and HTN / CKD / Hyperlipidaemia Flashcards
Chronic kidney disease - list the causes and risk factors for developing CKD
Causes:
- Hypertension
- Diabetes
- Glomerulonephritis
- Interstitial nephritis
- Polycystic kidney disease or other inherited kidney diseases
- Prolonged obstruction
- Recurrent pyelonephritis
Risk factors:
- Older age
- Hypertension
- Diabetes
- Smoking
- Nephrotoxic medications
Chronic kidney disease - list some symptoms and signs
Symptoms:
Can usually be asymptomatic
- Fatigue / lethargy
- Itchy skin
- Loss of appetite
- Confusion
- Insomnia
- Pulmonary oedema
- Peripheral oedema
Signs:
- Hypertension
- Oedema
- Electrolyte disturbances
- Anaemia
Chronic kidney disease - list some investigations to help confirm a diagnosis of CKD
- U&Es, looking at eGFR and serum creatinine
- Urine albumin:creatinine ratio (ACR), look for proteinuria
- Urine dip, look for haematuria
- (Renal) KUB ultrasound, for atypical patients
Chronic kidney disease - list some complications of CKD and how they are treated
Metabolic acidosis - oral sodium bicarbonate
Anaemia - iron supplementation and erythropoietin
Renal bone disease - Vitamin D
End stage renal failure - dialysis or renal transplant
Chronic kidney disease - list some indications for referral to a specialist
- eGFR < 30
- Raised ACR (≥ 70 mg/mmol)
- Accelerated progression defined as a 25% decrease in eGFR in 1 year
- Uncontrolled hypertension despite ≥ 4 antihypertensives
- Rare/genetic cause of CKD
Chronic kidney disease - outline the management steps
Slow progression:
- Optimise diabetic control
- Optimise hypertensive control
- Treat glomerulonephritis
Reduce risk of complications:
- Offer immunisations for influenza and pneumonia
- Exercise, maintain a healthy weight and stop smoking
- Special dietary advice about phosphate, sodium, potassium and water intake
- Offer atorvastatin 20mg for primary prevention of cardiovascular disease
Outline a rough definition of chronic kidney disease including how long it has to exist for
Reduction in kidney function or structural damage, present for > 3 months
Outline how chronic kidney disease is diagnosed (which parameters are looked at)
Markers of kidney damage:
- ACR ratio of > 3 mg/mmol
- Electrolyte disturbances
- Histological abnormalities (biopsy)
- Structural abnormalities (imaging)
Reduction in eGFR of < 60 ml.min.1.73m2
Outline any monitoring required for chronic kidney disease patients, looking for disease progression
Measure:
- eGFR
- ACR ratio
- FBC (anaemia)
- Serum calcium phosphate, PTH and vitamin D (renal bone disorder)
List some medications that might be offered in the management of CKD, to reduce CVS complications
Statins
- (20mg dose) used for primary prevention
Dapagliflozin
- SGLT2 inhibitor
Outline steps on how to reduce the risk of an AKI happening
- Regularly monitor U&Es (creatinine)
- Discuss the risk of AKI occuring in those with dehydrating conditions or nephrotoxic drugs
- Avoid nephrotoxic medications where possible
- Consider admission to hospital if pt appears hypovolaemic in primary care
Outline the ranges for hypertension classification (diagnostic criteria)
Normal < 120/80
Pre-hypertensive 120/80-140/90
Stage 1 hypertension 140/90 - 160/100
Stage 2 hypertension 160/100 - 180/120
Stage 3 hypertension either 180 or 120
Outline the symptoms of hypertension, including how hypertension presents in primary care
Almost always asymptomatic unless significant (> 180/110)
- Headaches
- Blurred vision
- Chest pain
- Dizziness
- Difficulty breathing
- Nausea / vomiting
- Anxiety
Outline some complications of hypertension
- Heart failure
- Coronary artery disease
- Stroke
- CKD
- PAD
- Vascular dementia
- Retinopathy
Outline the order of investigations for hypertension
If BP consistently over 140/90, offer:
- Ambulatory blood pressure monitoring
- Home blood pressure monitoring
Whilst waiting for confirmation, offer:
- Investigations for target organ damage or secondary causes of hypertension
- Assess CVS risk
Outline the lifestyle advice and medication management steps for hypertension
Lifestyle advice:
- Smoking cessation
- Reduce alcohol
- Reduce stress
- Increase exercise
- Weight loss / low fat diet
Medication:
- ACE-i / ARB or CCB
- Add other one in
- Add Thiazide-like diuretics e.g. Indapamide
- Add Spironolactone or beta-blocker
- Statins (QRISK score first)
Outline the investigation of hypertension in the following situations:
- Under 140/90
- 140/90 to 180/110
- > 180 or > 110
Under 140/90:
- Check BP every 5 years (sooner if very close to 140/90)
140/90 to 180/110:
- Offer ABPM (HBPM alternative)
- Investigate for target organ damage (non-urgent)
- Assess CVS risk factors
> 180 or > 110:
Urgent assessment for target organ damage
If target organ damage = start anti-hypertensives (without ABPM/HBPM)
If no target organ damage = repeating reading in 7 days and ABPM/HBPM and ensuring
Same-day specialist review if:
• Papilloedema
• Retinal haemorrhage
• Life-threatening symptoms
• Suspected pheochromocytoma
Outline the criteria for same-day specialist assessment for hypertension
Clinic BP either > 180 or >120 WITH signs of:
- Papilloedema
- Retinal haemorrhage
- Life threatening signs e.g. confusion, chest pain, HF, AKI
- Suspected pheochromocytoma
List BP targets in the following conditions
- Age < 80 years
- Age > 80 years
- CKD
- CKD and diabetes
Age < 80 years = < 140/90
Age > 80 years = < 150 / 90
CKD = between 120-140 / 90
CKD and diabetes (lower) = between 120-130 / 90
Outline the monitoring for hypertension
Annual review including:
- BP reading
- Review medication
- Discuss lifestyle
- Discuss issues with symptoms / medication
Outline the 2 possible causes of hypercholesterolaemia
- Familial hypercholesterolaemia
- Secondary hypercholesterolaemia
Outline when you would suspect that someone might have familial hypercholesterolaemia
- Total cholesterol greater than 7.5
- Personal or family history of premature CVS event (before 60 in a 1st degree relative)
- May also see tendon xanthomas or corneal arcus
Generally requires specialist involvement and genetic counselling
Outline some common causes of secondary hypercholesterolaemia
Lifestyle:
- Obesity
- Smoking
- Alcohol
Conditions:
- Diabetes
- Hypothyroidism
- CKD
- Nephrotic syndrome
- Primary biliary cholangitis (PBC)
- Pheochromocytoma
- Cushing’s syndrome
Drugs
List some drugs that can cause secondary hyperlipidaemia
- Steroids / Immunosuppressants
- Diuretics (thiazide)
- Beta-blockers
- Oestrogen / Progesterone
- Anti-HIV drugs
- Atypical antipsychotics
- Retinoids
State the name of the tool used to assess need for statin therapy in primary care
QRISK2 tool
Outline the role of the QRISK score, what the % score means and the significance of it being raised (>10%)
QRISK score is carried out to assess for the need of statin medication
- Estimates the percentage risk that a patient will have a stroke or myocardial infarction in the next 10 years
- QRISK of 10% means there is a 1 in 10 chance of developing a heart attack or stroke within the next 10 years
- If QRISK > 10%, offer a statin, initially Atorvastatin 20mg at night
Statins are also offered to all patients with:
- T1DM (for >10 years or over 40 years)
- CKD
Outline some complications of hyperlipidaemia
Cardiovascular disease
- Angina and ACS
- Stroke / TIA
- Peripheral arterial disease and claudication
- Acute limb ischaemia
- Erectile dysfunction
Outline the management of hyperlipidaemia for primary prevention and secondary prevention, including lifestyle advice and medications
Primary prevention - QRISK score:
Less than 10% = offer lifestyle changes e.g. healthy diet, increased exercise, weight loss, smoking cessation
Greater than 10% (or with T1DM if older or CKD) = offer 20mg Atorvastatin at night
Secondary prevention - higher doses (previous/existing CVD e.g. MI):
80mg Atorvastatin
Outline some rare and significant side effects of statins
- Myopathy
- Rhabdomyolysis
- Type 2 diabetes
- Haemorrhagic strokes (very rarely)
List some blood tests required prior to starting statins
- Lipid profile
- LFTs
- U&Es including eGFR
- HbA1c
- Creatine kinase (if muscle pains)
- Thyroid function tests if dyslipidaemia
What medication is offered to T1DM and CKD patients for primary prevention of CVS disease (hypercholesterolaemia)
20mg Atorvastatin
Don’t need to do a QRISK score - just give automatically
T1DM - if had it for > 10 years or > 40 years old