Week 10 Flashcards

1
Q

Supplements definition:

A

Supplements are added to supply a deficiency but in a sporting context are something used to improve performance.

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2
Q

Things athletes look for when deciding whether to use a supplement?

A

Athletes look at whether it helps:

  • improve health or performance
  • helps treat an illness/prevent an illness
  • Improve recovery
  • Helps compensate for a bad diet.
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3
Q

What may supplements claim to do?

A

Promote tissue growth, repair, adaptation to training, promote fat loss, enhance energy supply (including muscle buffering) (eg.carbohydratee nutritional buffers)
Promotes immume function and resistance to illness/infection,
CNS stimulant effects eg.caffeine, promotes joint health, promotes general health.

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4
Q

With supplements you need to do a cost-benefit analysis and see if they are worth if

A

Costs include:

  • Financial
  • health
  • performance
  • drug test failure

Benefits include:
Performance, health insurance, policy, free samples.

Many supplements cannot complete full analysis as the big picture is unknown.

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5
Q

What do anti-doping regulations do?

A

Anti- doping regulations provide liability in sport and help protect athletes health. The offence involves having the banned substance in your system. 1-2 % of athletes who do drugs tests then test positive.

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6
Q

Supplement use risk?

A
  1. ) Supplement could be contaminated due too poor quality control and storage
  2. ) Absence or lower levels than declared of ‘actives’- eg. in caffeine study some products do not even report the amount of caffeine and those which do often show variability in the amount of caffeine in each product.
  3. ) Presence of undeclared doping agents
  4. ) Can be harmful to health and performance
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7
Q

Sometimes contamination is not an accident

A

MHA led to cardiac issue. Often has been marketed as a dietary supplement for geranium- plant derived.
Was not actually oil from geranium that was used but was a synthetic version that was prohibited and some athletes were banned over it.

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8
Q

What is informed sport?

A

It is an accreditation company used to minimize risk of a supplement you consume containing anything prohibited.
Not every company will use such accreditation services as it costs them money to do so

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9
Q

How to determine the efficacy of a supplement?

A

You need to ask yourself?

  • What is the specific biochemical and physical function that supplements aimed at?
  • Does acute and or chronic exercise decrease the availability of the target substrate/ compound to an extent that will impair it’s normal physiological function and therefore exercise performance.
    eg. is that pathway affected by exercise and can limit performance, do we really need to supplement if it is not affected by sport.
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10
Q

How to determine the efficacy of a supplement

A
  1. ) Does the substrate/ compound reach it’s target destination?
  2. ) Does the substrate get there in a high enough concentration that is physiologically meaningful?
  3. ) Does an increased concentration have a measurable and reproducible effect on its biochemical / physiological effect during exercise?

4.) Does an increased concentration have a measurable or reproducible effect on exercise capacity or fatigue development

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11
Q

Maughan’s rules of dietary supplements for athletes

A

If it works it is probably not allowed

If it is allowed, it probably doesnt work. There are some exceptions.

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12
Q

What is the most commonly used drug?

A

Caffeine is the most commonly used drug.

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13
Q

How much caffeine is in an instant coffee and how much caffeine in a tea?

A

Caffeine = 40 -10 mg of caffeine.

Tea= 20-46 mg of caffeine

Caffeine content can vary in dietary supplements.

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14
Q

There is variability in caffeine content in coffee products

A
Coffee content  (all pods)
Caffeine content (all pods) ranged between 19 and 147 mg per serving
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15
Q

What is pharmokinetics?

A

Pharmokinetics = the movement of a drug into , through and out of the body.
Consists of: absorption, bioavailability , distribution, metabolism and excretion.

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16
Q

Caffeine absorption after ingestion involves:

A

BuccalMucousa and intestines

17
Q

Differing responses between caffeine gum and drink

A

Responses are similar between caffeine drink and gum and response peaked about 40 mins after exercise.

18
Q

How long does caffeine last ?

A

Half life/ time is time to reduce caffeine present by 50% and is about 4.7-4.9 hours in most people. Curve is not the same for every person.
Caffeine is readily absorbed in mouth and intestines and time to peak plasma conc is 30-90 mins.

Caffeine is metabolized in the liver by cytochrome p450 oxidase system.
Metabolites: paraxanthrine, theobromine, theophylline
1-3% of the caffeine is excreted in the urine.

19
Q

Caffeine effects?

A

Improves endurance and improves cognitive aspects of function.
Caffeine found to improve endurance by about 12%. However study found no improved effect with increased dosage and abstinence period did not have an effect- however this is controversial.

20
Q

Effects of caffeine dosage in the plasma

A

Lower dosage means lower caffeine in the plasma and higher dosage means higher caffeine in the plasma.

Dose effects- some studies suggest 3 mg/kg is enough for dose response and increasing further is not needed for an ergogenic response eg. 80 kg person should consume 240 mg.

21
Q

Caffeine side effects

A

Some individuals = sensitive to nervousness and tremor that acute caffeine consumption can induce.

Can lead to insomnia, diuresis - habituation , rest-exercise , withdrawal (headaches and lethargy)

22
Q

How does caffeine improve exercise performance?

A

Metabolic- caffeine increases lipolysis and muscle glycogen sparing
Neuromuscular- Caffeine increases muscle fibre excitability
Brain- caffeine has psychological or direct central effects via adenosine receptor antagonism or other unknown signaling pathways.

Metabolic- lipolysis and muscle glycogen utilization. Lipolysis breaks down fats for beta oxidation. Caffeine might increase lipolysis and fat oxidation and spare muscle glycogen in the muscle.

23
Q

Effects of caffeine on people in cycling study cycling for an hour at 70% of vo2 max/

A

Caffeine ingestion does not alter carb or fat metabolism in skeletal muscle during exercise.

Caffeine ingestion attenuated the decline in force output during low frequency tetanic stimulation of the calf muscle- caffeine decreased fatigue in the muscle and decrease the decrease in force experienced.

Caffeine reduces the RPE experienced during constant load exercise. e.g rpe time trial exercise the RPE is the same but the power is more in the caffeine group.

24
Q

Brain and adenosine relation to caffeine

A

Adenosine = an inhibitory modulator of neuronal excitability and synaptic transmission by activation of adenosine receptors. It inhibits the release of the brains most excitatory neurotransmitters e.g. dopamine
Caffeine decreases arousal, suppresses behavioral activity and decreases sleep.

Caffeine is an adenosine antagonist (blocker).

25
Q

What is carnitine?, where can it be found in the human body?, where do we source it from?

A

Carnitine = a naturally occurring amino acid derivative
95% of the carnitine found in the human body is found in skeletal muscle. Found in diet e.g. red meat and dairy. It can also be endogenously synthesised by methionine and lysine in the liver and kidneys. Loses = small and are in the urine and stool.

26
Q

What is carnitine important for?

A

Carnitine is important for glucose and fat oxidation in the muscle.
L-carnitine = important in fat oxidation- helps transport fatty acids from cytosol in the muscle to the fatty acids within the mitochondria for beta oxidation of fatty acids. If you do not have enough carnitine present there is a limitation of how much fatty acids you can get to the right place.
Carnitine also important for the aerobic metabolism of carbohydrate as if not enough carnitine is present then may not be able to convert pyruvate into acetyl coA and then go into the tca cycle etc

27
Q

Effect of higher intensity exercise on glycogen utilisation?

A

Higher intensity exercise = greater glycogen utilization. Process is reliant on carnitine and thought the more intense the exercise undertaken the less carnitine that will be available. Longer duration of exercise relies on fats and if not enough carnitine is present then cannot get fatty acids to the mitochondria, so cannot be beta oxidized and cannot get energy from them.

28
Q

Carnitine effects on endurance exercise.

A

More efficient fat oxidation leads to glycogen sparing.
Without supplementation of carnitine the carnitine conc in the muscle is far too low too encourage fat oxidation, Carnitine supplementation helps increase carnitine present in the muscle- this increases fat oxidation, decreases glycogen oxidation and reduces muscle fatigue.

29
Q

Carnitine effects in high intensity exercise

A

Effects of high intensity exercise on carnitine is increased carbohydrate oxidation. If glycolytic flux exceeds tca cycle flux the carnitine is then acetylated. When free carnitine is low acetyl coA accumulates and less free coA is available. Limited pool of coA limits PDH activity and can lead to H+ and lactate accumulation and muscle fatigue from acidosis. In high intensity exercise supply of carnitine makes oxidation of carnitine more efficient- less acidity in the muscle and less fatigue due to acidosis.

30
Q

No changes in carnitine in the muscle after oral supplementation.

A

Oral carnitine supplementation does not seem to change the amount of carnitine in the muscle- carnitine is not very bioavailable so little amounts of carnitine get into the muscle. Also does not increase very much as has to go against a large concentration gradient. Carnitine supplementation has no effect on substrate utilization. Glycogen use is exactly the same after carnitine supplementation.

31
Q

Insulin stimulates l-carnitine accumulation in human skeletal muscle.

A

Injection of carnitine did not increase carnitine concentration within the muscle. Carnitine transportation is regulated by insulin so if you inject carnitine with insulin get an increase in muscle concentration of carnitine- increased by 15%. It is not practical injecting carnitine. Supposedly at high intensity exercise injecting both increases efficiency of aerobic energy production and causes less lactate to be produced. There is muscle glycogen sparing occurring at low intensity exercise. Also improved exercise performance.

32
Q

Muscle carnitine and carb supplementation

A

Likely to be useful for those in submaximal events where glycogen availability can become a limiting factor. It would likely be useful in an an event like the 1500m as it would make glucose oxidation more efficient. Need several months supplementation to increase muscle carnitine and carbohydrate co-ingestion is needed to increase muscle carnitine.