Week 1 material Flashcards
Pyrimidines
C, T, U
Purines
A, G
How many H bonds in G - C?
3
How many H bonds in A - T/U?
2
Do all bp (e.g. A-T/U or G - C) have equivalent energy despite having the same # of bonds?
No
Laws vs Rules
Laws: NO exceptions
Rules: exceptions but not always
Rule 1a: for every rule, there is an exception
When can a law turn into a rule?
Is this rule valid?
When an exception to a law is found
No, given the rule must have an exception too
What are rules 1a + b
1a: for every LAW of science, there is NO exception
1b: the more you understand, the less you need to memorize
Variation in codon position attributed to G - C position?
aka the graph
Position 1: MEDIUM variation
Position 2: LEAST variation
Position 3: GREATEST variation
Most important 2 > 1 > 3
Which position is most important? why?
Which position is least important? why
Position 2 given greatest variation
Position 3 given least variation
What does P1 deals w/ in terms of aa?
IDENTITY of aa
AKA which of the 22 aa
What does P2 deals w/ in terms of aa?
TYPE of aa
AKA hydrophobic, semipolar, hydrophilic
What does P3 deals w/ in terms of aa?
Wobble except in initiation
p1 is wobble in initiation: rule 4
Position 2 + 3 are ALWAYS…
a) purines
b) pyrimidines
Purines
Position 2 is always purines. Which purine is MOST common?
a) A
b) G
A
If codon P2 is T, then the type of aa will be…
Hydrophobic
If codon P2 is C, then the type of aa will be…
Semipolar aa
If codon P2 is A, then the type of aa will be…
Hydrophillic + ocher + amber
If codon P2 is G, then the type of aa will be…
Semipolar + opal + Arg (exception)
P2 determined importance of P3. If P2 is C, then P3 is…
a) irrelevant
b) relevant
c) somewhat relevant
a) irrelevant