Week 1 - complete Flashcards
Sign vs symptom?
Sign: what the physician identifies on PEx
Symptom: What the patient perceives
What are the 4 types of clinical presentations?
- Undifferentiated
- Single typical
- Multisystem
- Preventative care/health promotion
Give an example of each type of clinical presentation
- Undifferentiated: fatigue, malaise
- Single typical: abdominal pain, diarrhea, knee swelling
- Multisystem: fever, cough
- Preventative care/health promotion: cancer, pap smear, blood screening
What are the steps in the diagnostic pathway?
- assess stability (vitals [ABC])
- History
- Physical exam
- Investigations
What are the main vitals to assess?
ABCs: airway, breathing, circulation
AKA blood pressure, HR, resp rate, temperature. O2 saturation can be extra
What is the framework used to develop a DDx?
Vitamin C&D
What does Vitamin C&D stand for?
Vascular
Infection/inflammation
Traumatic/toxic
Autoimmune/acquired/allergic
Metabolic/mental health
Iatrogenic
Neoplastic
Congenital
Degenerative
What is the framework for picking which investigations to use?
Choosing wisely
How do you choose which investigations to conduct?
Based on potential DDX based on patient history and physical exam
What are some aspects of choosing wisely?
Choose least invasive, high yield tests that will actually change patient management
Avoid unnecessary rule-out testing or tests for the learning experience
What is pre-test probability?
The probability that your patient actually has the illness you’re testing for
What is the post-predictive value of a test?
Positive predictive value is the probability that subjects with a positive screening test truly have the disease.
What are the 5 types of investigations to choose from?
- Biochemistry
- Microbiology
- Hematology
- Pathology
- Imaging
Describe biochemistry Ix
Function and metabolic tests and markers
Describe microbiology Ix
Infection workup
Describe hematology Ix
blood cells and elements, clotting parameters
Describe pathology Ix
autopsy, surgical pathology (tissue), cytopathology
Describe imaging Ix
Xray, CT, MRI, ultrasound, PET
What is important when doing Ix? Why?
Ensuring proper sample collection to ensure specimen viability
How many types of biopsies are there?
4
What are the 4 types of biopsies?
- Fine needle aspiration
- Needle core
- Punch
- Incisional and excisional
When do you use fine needle aspiration?
For palpable or deep lesions
When do you use needle core biopsies?
For deeper lesions, specific sites
When do you use punch biopsies?
For shallow samples, skin lesions only
When do you use incisional and excisional biopsies?
Incisional: for diagnosis
Excisional: for diagnosis AND treatment
In the case of fatigue, what might be a main vs an associated symptom?
Main symptom = fatigue
Associated symptoms = breathlessness, malaise, confusion
What is the first thing to do when determining the clinical presentation type?
See if it is life threatening (check vitals)
What is the key feature?
The key in understanding a case. Its not necessarily the symptom or what the patient is saying they’re there for.
For instance, rapid symptom onset could be the key feature of a case
What are 2 types of physical exam?
General and focused
Describe general vs focused PEx
general: whole body
Focused: prioritize areas that are relevant to the patient’s symptoms
What are social determinants of health?
Non-medical and non-biological influencers that affect health and health outcomes
What are examples of social determinants of health?
Race, employment status, education, lifestyle activities, social life