Week 1- ANS Flashcards

1
Q

what are the effects of adrenergic blocking agents?

A

inhibit or lyse stimulation of sympathetic nervous system and NT’s

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2
Q

What are the 3 basic nervous system functions?

A

Recognizing sensory input or stimuli

Processing and integrating the stimuli

Reacting and responding to the stimuli (producing the motor output)

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2
Q

What are the effects of beta adrenergic agonists?

A

know all: bronchial, GI smooth muscle, and uterine smooth muscle relaxation, glycogenolysis, and cardiac stimulation

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3
Q

Which NT is dopamine similar to and what is its mechanism of action?

A

similar to epinephrine (even though it is an inhibitory NT) that causes vasodilation of select arteries = increased blood flow in the renal, mesenteric, coronary and cerebral arteries.

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4
Q

the Nervous–>PNS–> MOTOR division is further divided into what?

A

Somatic Nervous system and Autonomic Nervous systen (ANS)

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5
Q

what do alpha2 adrenergic receptors do?

A

control release of NE located on the presynaptic nerve terminal

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5
Q

What is the mechanism of cholinergic antagonists?

A

drugs that inhibit or block action of ACH in parasympathetic nervous system

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6
Q

Most imp NT’s (or chemical msg) in Pharm are?

A

*DEANS*

Dopamine

Epinephrine

Acetylcholine

Norepinephrine

Serotonin

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6
Q

What do alpha1 adrenergic receptors do?

A

target cell muscle or organ stimulated by nerve located on postsynaptic effector target

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7
Q

What are the effects of cholinergic agonists?

A

*SLUDGE*

Salivation

Lacrimation

Urinary Incontinence

Diarrhea

GI cramps

Emesis

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8
Q

where are beta- adrenergic receptors located?

A

all are located on the postsynaptic effector cells

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9
Q

What is the basic functional unit of the nervous system?

A

the neuron

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9
Q

Where are the NT in axon terminals held?

A

vesicles

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10
Q

Where are the postganglionic neurons located?

A

outside the CNS in the PNS bc its axon terminates the signal on the effector cell/tissue/or organ. *** (CNS)pregang—ganglia synapse ANS—post(PNS)

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11
Q

What are the two major control systems?

A

Endocrine–> Slow control

Nervous –> Fast control

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12
Q

what is the originating neuron called?

A

presynaptic neuron

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12
Q

what is the receiving neuron called?

A

postsynaptic neuron

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12
Q

define: Adrenergic agonists

A

aka sympathomimetics bc they stimulate the sympathetic nervous system

mimic: EPI, NE mainly ALPHA-adrenergic effects

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14
Q

define: synaptic cleft

A

gap btw adjacent neurons

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15
Q

What are ganglia and what is their purpose?

A

clusters of neuron cell bodies OUTSIDE the CNS that serve as synapse stations for ANS

17
Q

WHat do both major control systems use to transmit info as messengers?

A

Both use Chemicals

Endocrine: uses hormones Nervous: uses NT

18
Q

Define: Sensory division

A

or Afferent division: nerve fibers that carry info to the CNS

19
Q

What are the two types of cholinergic receptors?

A

remember that it binds with ACH Muscarinic and Nicotinic receptors

21
Q

the ANS has what type of control over which muscle or tissue?

A

Involuntary control (vs voluntary like the somatic ) over smooth muscle, cardiac muscle and glandular tissue

23
Q

What are the two major nervous systems?

A

CNS and PNS

24
Q

Where are the beta1 and beta2 adrenergic receptors found?

A

1 heart, 2 lungs

beta1- primarily in the heart

beta2- in smooth muscle like bronchioles, arterioles, and visceral organs

26
Q

Define: synapse

A

junction btw nerves

27
Q

What is in the gray matter of the CNS?

A

neuron cell bodies, tracts and unmyelinated axons

28
Q

Name the excitatory NT’s and what they do?

A

They stimulate(*excite*) the nerve impulse: dEANs

EPI, ACH, NE

28
Q

Adrenergic receptors are sub-divided into which receptors and what do they bind to?

A

Alpha-adrenergic receptors- binds to NE

Beta-adrenergic receptors- binds to EPI

28
Q

What are the effects of the beta2 adrenergic agonist drugs?

A

2 lungs- bronchodilation, uterine relaxation, glycogenolysis in the liver (glycogen–>glucose)

29
Q

Neurons have two specialized extensions: axons and dendrites. Which conducts toward the cell and which conducts away from the cell?

A

dendrites: conduct toward the cell

Axons: conduct Away from the cell

30
Q

What are the effects of alpha adrenergic agonists?

A

vasoconstriction and stimulation the CNS, male ejaculation, decreased insulin release

32
Q

Name the 3 Types of NT receptors?

A

*CAD*

Cholinergic- binds to ACH

Adrenergic- binds to Catecholamines (EPI, NE)

Dopaminergic- binds to dopamine

33
Q

which bodily functions are regulated by the ANS?

A

RUBDoWn- BH

Respiration

Urinary excretion

BP Digestive fx

Water balance

Body Temp

Heart Rate

35
Q

Sympathetic branch is known as what?

A

fight or flight

36
Q

What are the functions of the ANS?

A

regulate and integrate the body’s internal functions

integrate parts of the CNS and PNS to react to changes in the internal and external environment

37
Q

parasympathetic is known as what?

A

rest and digest

38
Q

Nervous–>PNS–> MOTOR division–> ANS is divided into??

A

Sympathetic and Parasympathetic branch

39
Q

Where are preganglionic neuron cell bodies located?

A

inside the CNS *** (CNS)pregang—ganglia synapse ANS—post(PNS)

40
Q

Where are the beta1 adrenergic agonists located?

A

1 heart- located in the myocardium AV node and SA node

41
Q

What are the effects of the beta1 adrenergic agonist drugs?

A

cardiac stimulation: positive inotropic(force of contraction), positive chronotropic (heart rate), and positive dromotropic effect (conduction speed of AV node).

42
Q

What is the PNS divided into?

A

Sensory and Motor divisions

43
Q

why are NT, axons, and neurons imp in pharm?

A

Bc many drugs act like NT, some block the NT form binding to its receptor and some enhance NT action

44
Q

Define: Motor Division

A

or Efferent division (E for effort of a motor): nerve fibers that carry impulses away from the CNS, to the effector cell/tissue

45
Q

What are other names of adrenergic-blocking agents?

A

adrenergic antagonist or sympatholytics

47
Q

Name the Inhibitory NT’s and what they do?

A

They inhibit the nerve impulse. (DeanS + G)

Dopamine, Serotonin and GABA

48
Q

what are cholinergic agonists?

A

drugs that bind to cholinergic receptors- act like ACH aka parasympathomimetics

49
Q

When NT crosses the synapse what does it bind with on the effector structure (target tissue)?

A

Specific Receptors