Week 1 + 2: Randoms

Question 1

Lamina

Answer 1

• Component of basal lamina (on muscle)

- stops growth cone and starts accumulation of synaptic vesicles

Question 2

Agrin

Answer 2

Made in motor neuron
- Agrin receptor = complex MuSK
- Activation = Aggregation of Ach receptors
Note: postnatal, replaces gamma subunits with E subunits.
Note: Rapsyn.

Question 3

Wernicke area: Location + Aphasia

Answer 3

• left posterior superior and middle temporal cortex

- Loss of receptive + comprehension but still able to speak fluently.

Question 4

Brocha area: Location + Aphasia

Answer 4

• left posterior frontal cortex + underlying structures

- Impaired speech but is able to understand simple sentences

Question 5

Learning of frequency + intensity vs duration

Answer 5

• Frequency and intensity = adult level by 6 months

- Duration = adult level by 5-10 years

Question 6

Longevity: IGF-1 + TOR + TOR inhibitor

Answer 6

• Increase Longevity: Inhibition of IGF-1 or TOR

Note: deletion of TSC1 (mTOR inhibitor) leads to decrease longevity.

Question 7

Werner Syndrome

Answer 7

• Mut: WRN Chromosome 8 = DNA/RNA helicase (Nuclear translocation sequence)
• Normal development until puberty
• Death at 56 yo (MI, cancer, etc. Cataracts too)

Question 8

Hutchinson-Gilford Syndrome

Answer 8

• Mut: LMNA = Nuclear intermediate
• Leads to accumulation of progerin
• Growth restriction by 6 months, death by 14 yo.

Question 9

Treatment of ADHD

Answer 9

1) Dextroamphetamine = only FDA approved medication for

Question 10

Treatment for Autsim

Answer 10

Risperidone + Aripiprazole: Atypical psychotics
- ONLY medication approved in the treatment of autism spectrum disorder

Fluoxetine: SSRI, treat repetitive behavior, anxiety, behavior

Lithium: Mood disorders