Week 1/2 Pharmacokinetics Flashcards
1
Q
What proteins do basic drugs bind to?
A
Lipoproteins or acid glycoproteins
2
Q
What proteins do acidic drugs bind to?
A
Albumin
3
Q
What proteins do hormones bind to?
A
Globulins
4
Q
A drug which meets what 3 criteria would be more likely to be affected by a change in protein binding
A
- Low VD
- High protein binding
- Narrow therapeutic ratio
5
Q
What are some conditions which can affect protein binding?
A
Hypoalbuminaemia
Pregnancy
Renal failure
Displacement by other drugs
