week 1

Question 1

Receptors have three common
properties

Answer 1

Sensitivity, Selectivity, Specificity

Question 2

Sensitivity

Answer 2

Drug response occurs from a low
concentration

Question 3

Selectivity

Answer 3

Produced by structurally similar chemicals

Question 4

Specificity

Answer 4

The response from a given set of receptors is
always the same because the cells themselves
determine the response

Question 5

Bonds that form between drugs and
receptors

Answer 5

– van der Waals
– Hydrophobic
– Hydrogen
– Ionic
– Covalent

Question 6

Affinity

Answer 6

Degree of attraction between
a drug and its receptor on the cell’s
surface

Question 7

Efficacy

Answer 7

a drug’s capacity to produce
an effect

Question 8

Pure Antagonists

Answer 8

– Are similar in molecular structure to
their corresponding agonist drugs
– They have receptor affinity, but lack
intrinsic activity or efficacy

Question 9

Agonist-Antagonists

Answer 9

Second major type of antagonist drugs
– Have receptor protein affinity and
intrinsic activity, but often only a
fraction of the potency of the pure
agonist
* Nalbuphine (mixed agonist-antagonist)

Question 10

Physiologic Antagonism

Answer 10

– Involves two agonist drugs that bind to
different receptors
– Both drugs bind to specific unrelated
receptor proteins and initiate a protein
conformational shift with elicited
individual tissue response
– These responses however generate
opposing forces
* Isuprel and Levophed

Question 11

Chemical Antagonism

Answer 11

– Occurs when a drugs action is blocked
and no receptor activity is involved
– Example
* Protamine
* Sugammadex