Week 1 Flashcards
what are the effects of ace inhibitors on fetuses?
Renal tubular dysplasia causing renal failure and fetal or neonatal death and intrauterine growth restriction
how does warfarin affect fetuses?
Spontaneous abortion, fetal demise, fetal or newborn hemorrhage, CNS abnormalities
how does the cytomegalovirus affect fetuses?
Hydrocephaly, microcephaly, cerebral calcification, mental retardation, hearing loss
how does herpes varicella affect fetuses?
Hypoplasia of hands and feet, blindness and cataracts, and mental retardation
how does rubella affect fetuses?
Risk of heart defects, deafness or blindness, mental retardation, and fetal demise
how does syphilis affect fetuses?
Risk of skin, bone and teeth defects, and fetal demise
What are the three phases of the ovarian cycle?
follicular ovulatory and luteal phases
what are the three phases of the endometrial cycle?
Proliferative, secretary, and menstrual phases
in which menstrual cycle phase does the luteal hormone and follicle-stimulating hormone increase? What is their function?
To mature the Graafian follicle and produce estrogen; in the follicular phase
which phase does estrogen levels peak?
ovulatory
a surge in what hormone occurs before ovulation and what happens to other hormones?
Luteal hormone surges 12 to 36 hours, and estrogen decreases and progesterone increases
When does the luteal phase begin?
after ovulation, lasting for about 14 days
what happens in the luteal phase?
Empty follicles morph to form the corpus luteum which causes high progesterone and low estrogen to support a pregnancy
when does the proliferative phase begin?
After menstruation ending with ovulation
when does the secretory phase begin and end with?
After ovulation and ends with menstruation
what happens during the secretory phase and what hormone is secreted?
The endometrium thickens and progesterone is secreted from the corpus luteum
what happens to the endometrium if there is a pregnancy?
Why coercion is produced to become an energy source for the blastocyst
in approximately 12 days what forms in the fetus?
Embryonic disc
In fetal development what is created in approximately 20 days?
The head of the embryo
when would you see the head of the embryo, limb buds, and the umbilical cord?
Approximately 4 to 5 weeks
what should the fetal heart tones be in the first trimester?
110-160 bpm
What kind of tissue is the placenta formed from?
fetal and maternal
what are two functions of the placenta?
Metabolic and gas exchange
hormone production
what are hormones produced in the placenta?
Progesterone, estrogen, hCG, hPL
What are the two parts of the amniotic sac and which is the inner and which is the outer?
The amniotic membrane (inner) and the chorionic membrane (outer)
what does progesterone do in the placenta?
Facilitates implantation and decreases uterine contractility
what does estrogen do in the placenta?
Stimulates the enlargement of the breasts and uterus
what does the hormone hCG do in the placenta?
Stimulates the corpus luteum to continue secreting estrogen and progesterone until the placenta is mature enough to secrete these hormones
why is the hormone hCG important to test in pregnancy?
It rises in the first trimester and then has a rapid decline until 100-130 days
what does the hormone hPL do in the placenta?
Promotes fuel growth by regulating glucose available to the developing human
stimulates breast development and preparation for lactation
what are some viruses that can cross the placental membrane?
Rubella cytomegalovirus
at what week of gestation is the placenta fully functional?
8-10 Weeks
by the 9th month the placenta is how many grams, how many centimeters thick, and how many centimeters across?
15-25 cm In diameter, 3 cm thick, and ways approximately 600 grams
what is the amniotic sac made of?
Water, proteins, carbs, lipids, electrolytes, fetal cells, lanugo, and vernix caseosa
what is the function of amniotic fluid?
Cushions fetus, prevents adherence of fetus to amniotic membranes, allows freedom of fetal movement to aid in symmetrical musculoskeletal development, and provides a consistent thermal environment
what are some abnormalities of the amniotic fluid?
Polyhydramnios
oligohydramnios
what is the definition of oligohydramnios? What can it lead to?
Decrease the amount of amniotic fluid less than 500 milliliters at term or 50% reduction of normal amount which causes decrease in placental function and can cause congenital renal problems
what is the definition of polyhydramnios? What kind of complications can it lead to?
Excessive amount of fluid 1500 to 2,000 milliliters which can increase the incidence of chromosomal, gastrointestinal, cardiac or neural tube disorders
what are the three fetal circulation?
Ductus venosus
foramen Ovale
ductus arteriosus
What is the medication that induces ovulation?
Clomid also known as clomiphene citrate
what are some lifestyle changes that can impact fertility?
Improved nutrition, elimination of tobacco, stress, and other drugs
what are some surgeries to induce fertility?
Surgery to open up tubes, remove uterine fibroids called myomectomy
why might antibiotics be used as fertility treatments?
They can help with getting rid of infections in the cervix
what is the indication of clomid?
anovulatory infertility
what is the action of clomid?
Stimulates release of FSH and LH, which stimulates ovulation
what are some common side effects of clomid?
Hot flashes, breast discomfort, headaches, and insomnia
when should clomid be taken?
PO from cycle day three to seven
what are some barriers to conception in females?
Age greater than 35, abnormal uterine contours, history of STI’s, tobacco use, nutritional deficiencies, occupational or environmental risks, and abnormal secondary sexual characteristics
what are some barriers to conception regarding males?
Medical history of mumps especially after adolescence endocrine disorders, frequency of intercourse and history of STI’s, alcohol tobacco heroin and methadone use, and exposure to hazardous teratogenic materials in the home or work environment, and exposure of scrotum to high temperatures
What are some physiological changes in the reproductive system regarding the breasts?
Tenderness, feeling of fullness, and tingling sensation
increase in weight my 400 grams
enlargement of breasts, nipples, and areola add Montgomery follicles
what causes the breasts to increase during pregnancy?
Increase of prolactin which increases blood supply to the breasts
what does prolactin do to the breasts?
Increase the growth of mammary glands, lactiferous ducts and alveolar system, and production of colostrum
what is colostrum and when is it produced?
Yellow secretion rich in antibodies which is secreted as early as 16 weeks
what are some physiological changes in the reproductive system regarding the uterus?
Hypertrophy of the uterine wall
uterus contractility increases because increased estrogen levels (also known as Braxton Hicks contractions)
Enlargement and stretching of uterus to accommodate developing fetus and placenta
what are some physiological changes regarding the cervix and vagina?
Softening of the vaginal muscles and connective tissue to prepare for fetus expulsion
hypertrophy of cervical glands to form mucus plug as a barrier
increased vascularity and hypertrophy of vaginal and cervical glands leading to leukorrhea
expanded circulatory volume leads to increased what in the reproductive system?
Blood flow to the uterus is 500 to 600 mL/min at term
Goodells sign: softening of the cervix
Hegar’s sign: softening of the lower uterine segment
Chadwicks sign: bluish cervix, vaginal mucosa, and vulva
what happens to the pH of the vagina in pregnancy?
It becomes more acidic to inhibit the growth of bacteria but it also allows the growth of candida albicans, increasing the risk of a yeast infection
what are some physiological changes regarding the blood pressure?
decrease in peripheral vascular resistance and BP
what happens to blood volume, BMR, and cardiac output in pregnancy?
Blood volume increases by 40 to 45%
cardiac output increases by 40%
BMR increases to 10 to 20% by the 3rd trimester
what happens to what are some signs of increased blood volume and cardiac output during pregnancy?
Hypervolemia of pregnancy
increased heart rate of 15 to 20 beats per minute increased stroke volume of 25 to 30%
systolic murmurs, load and wide S1 split, load S2, obvious S3
increase in heart size
what happens to the WBC count during pregnancy?
Values up to 16,000 square millimeters w/o infection
what constitutes iron deficiency anemia in pregnant people?
Hemoglobin less than 11 grams per dL
hematocrit less than 33%
what are some signs and symptoms of increased venous blood pressure and decreased blood flow to the extremities?
Edema of the lower extremities
varicosities and leg and vulva
hemorrhoids
what might cause supine hypotensive syndrome?
When a pregnant woman lays down and it compresses the inferior vena cava causing reduced blood flow back to the right atrium
why might tidal volume increase during pregnancy?
Hormones stimulate the respiratory center and act on lung tissue to increase and enhance respiratory function
what is the oxygen consumption in pregnant people?
Increase by 15 to 20%
what are some signs and symptoms of changing respiration during pregnancy?
Increase in total volume by 35 to 50%
slight increase in respiratory rate
increase in inspiratory capacity
decrease in expiratory volume
slight hyperventilation and respiratory alkalosis
what hormones are responsible for smooth muscle relaxation?
Estrogen, progesterone, and prostaglandins
estrogen, progesterone and prostaglandins affect the respiratory system how?
Dyspnea, nasal and sinus congestion, and epistaxis
what are some signs that the diaphragm is becoming displaced by the uterus?
There’s a shift from abdominal to thoracic breathing
what happens to the renal system during pregnancy?
Increased cardiac output and blood plasma volume increases blood flow in the first trimester by 50 to 80% and then decreases
why might a woman have UTI’s during pregnancy?
Increased progesterone levels causes relaxation of the sphincters
what urinary habits might a woman in her 3rd trimester experience?
Urinary frequency and nocturia
what is hyperemia?
Increased vascularity and bloodflow to organs or other part of the body
what are some signs and symptoms of increased hCG levels?
Nausea and vomiting during early pregnancy
increased progesterone levels can cause what to the GI system?
Relax smooth muscles to slow the digestive process and movement of stool causing bloating, flatulence, and constipation
how does gallstone formation end Cholestasis increase in pregnancy?
Increased progesterone levels decrease muscle tone of gallbladder and result in prolonged emptying time
increased levels of estrogen can lead to what regarding blood flow and bleeding?
Increased vascular congestion of the mucosa, gingivitis, bleeding gums, which increase the risk of periodontal disease
when might a woman feel a round ligament spasm?
During their second trimester belly distends with diastasis recti
what are some musculoskeletal signs and symptoms of a pregnant person?
Altered gate such as waddling, low back pain or pelvic discomfort, pelvic tilts such as lordosis, and increased risk of falls
what are three signs and symptoms of estrogen and progesterone’s effect on the integumentary system?
Linea nigra
melasma also known as chloasma
increased pigmentation of nipples, areola, vulva, scars, and moles
increase blood flow affects the integumentary system how?
Hot flashes, facial flushing, alternating sensations of hot and cold, and increased perspiration
what causes the cutaneous elastic tissues to become fragile and what happens to the skin?
Increased adrenal corticosteroids me too stretch marks or striae gravidarum
increased estrogen levels can cause what color and vascular changes?
Angiomas
Palmarerythema- pinkish red mottling over palms of hands and redness of fingers
increased androgens lead to what in pregnancy?
Increased oiliness of skin and acne
decreased follicle stimulating hormones in pregnancy lead to what?
Amenorrhea
increased progesterone generally leads to what in pregnancy?
Maintains pregnancy by relaxation of smooth muscles
decreases uterine activity to reduce spontaneous abortions
decreases gastrointestinal motility and slows digestive processes
increased estrogen generally leads to what in pregnancy?
Facilitates uterine and breast development, increases in vascularity, and hyperpigmentation
alters metabolic processes and fluid and electrolyte balance
increased oxytocin leads to what in pregnancy?
Stimulates uterine contractions and milk let down or ejection reflex in response to breastfeeding
what does increased human chorionic gonadotropin hormone lead to?
Facilitates sentence of corpus luteum until the placenta becomes fully functional
what does human placental lactogen or human chorionic somatomammotropin hormone do?
Facilitates breast development
alters carb and protein and fat metabolism
facilitates fetal growth by altering maternal metabolism by acting as an insulin antagonist
what does hyperplasia and increased vascularity of the thyroid manifest as?
Enlargement of thyroid
heat intolerance and fatigue
increased BMR can lead to what alteration and blood sugar?
Depletion of maternal glucose stores leads to increased risk of maternal hypoglycemia
why does insulin production increase in pregnancy?
There is an increased need for glucose from the developing fetus
how does increased circulating cortisol manifest as?
Increase in maternal resistance to insulin leads to increased risk of hyperglycemia
At what week should the fundus be at the umbilicus?
20