Week 1 Flashcards

1
Q

Body Wall

A

portion of the body that forms the external body surface and encloses the body cavity

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2
Q

Body wall layer organization

A

skin, muscle, connective tissue, thoracic (pleural/pericardial) cavity and abdominopelvic cavity (peritoneal cavity), limbs are extensions of the body wall

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3
Q

Body wall organization (cont.)

A

Skin (epidermis/dermis), Superficial fascia (Camper’s fascia, Scarpa’s fascia), Skeletal Muscle, Bones, Tendons, and Deep fascia (envelops bones and muscles), Celomic lining (parietal pleura/parietal peritoneum)

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4
Q

Body wall Muscles

A

Rectus+ external/internal/transversus (all concentric)
Abdomen- Rectus abdominus, Exernal abdominal oblique, internal abdominal oblique, transversus abdominis, transversalis fascia, parietal peritoneum
Thorax- external intercostal, internal, and transversus (which includes innermost intercostal)

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5
Q

Muscles involved in breathing

A

Inspiration: Pectoralis, Serratus Anterior, External intercostal, Diaphragm
Expiration: Internal Intercostal, addominals

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6
Q

Other abdominal muscles

A

Aponeuroses- where the 3 concentric layers of muscle terminate
Linea alba- where the aponeuroses fibers terminate
Rectus sheath (which are layers of aponeuroses) - encloses the rectus abdominis muscle

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7
Q

TBS

A

the wall of the abdomen and thorax is organized like a stack of similarly structured circles because each segment is derived from a single somite

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8
Q

Sites of Ectopic Pregnancy

A

Normal- upper posterior uterine wall
Ectopic sites- tubal (most common), abdominal (mesentary of the intestines), ovarian, cervical
Ex. blastocystwould escape to addominoplevic cavity, always terminate pregnancy because death due to hemorrhage is very likely

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9
Q

Week 2- Implantation

A

inner cell mass sinks into upper posterior uterine wall, extraembroynic membrane formation- amnion, chorinon, yolk sac

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10
Q

Extraembroynic membrane (origin and fate)

A

Chorion- derives from trophoblast(synctio and cytotrophoblast) and mesoderm, makes chorionic villi
Amnion- continuous with the epiblast/ectoderm
Yolk Sac- continuous with hypoblast/endoderm
Both amnion and yolk sac come from inner cell mass

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11
Q

How do the layers of the chorion relate to the structure of the placenta

A

All three layers of the chorion invade the endometrium as villi
The synctiotrophoblast is in direct contact with maternal blood, the extraembryonic mesoderm forms connective tissue core of the villi and the cytotrophoblast eventually disappears

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12
Q

Primordia (origin and general fate)
Primitive knot and primitive streak

Neural tube and neural crest

Cardiogenic plate
Notochord

Paraxial Columns

Intermediate column
Lateral plate

Surface ectoderm
Mesenchyme

A

embryonic ectoderm thickening; Intraembryonic mesoderm, notochord
notochord induces ectoderm to form plate; nervous system
mesoderm in front of the oral membrane from primitive streak; heart
Primitive knot; nucleus pulposis; induces neurulation
Intraembryonic mesoderm; segmental somites, bone, muscle and dermis
UG system
pleura, peritoneum, connective tissue of organs and body well (intraembryoic coelom)

Primitive streak

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13
Q

Describe how tri-laminar gastrula folds in 4th week

A

Gastrula folds into cylinder, forms vertebral body plan. Folds at two sites of the amnion

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14
Q

Describe how the endoderm is shaped into the gut tube during folding of the embryonic disc

A

Endoderm forms epithelial gut and airway lining, and intraembryonic mesoderm remain the same place, intraembryonic coelom (from lateral plate mesoderm) increases in size and compresses the mesodermal lining of the coelom

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15
Q

Lateral plate mesoderm

A

Somatopleure- surface ectoderm and mesoderm from lateral plate, body wall (bone, partietal pleura and peritoneum, muscle, skin)
Splanchnopleure- endoderm and mesoderm from lateral plate, gut wall (epithelium), visceral peritoneum and pleura
Mesentary- two sheets of visceral peritoneum that suspends the gut tube from the body wall and provides a rout for vessels and nerves to supply the GI organs

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16
Q

Dizygotic vs Monozygotic

A

Dizygotic- two zygotes= 2 chorions= 2 placentas= 2 amnions

Monozygotic- Inner cell mass division (totipotent) with 2 amnions but 1 of everything else

17
Q

Spinal Nerves

A

Spinal nerves, innervate body wall, deep and cutaneous, contain both afferent and efferent

18
Q

Cell bodies

A

Spinal- in DRG and ventral horn
Cranial- in brain
Autonomic- lateral horn

19
Q

Neurulation

A

Neural plate folds into neural tube (all cell bodies in the CNS) and the neural crest pinches off (all ganglia outside of the spinal cord)
Neural tube defects: Rachischisis, menigocele, myelomenigocele, spina bifida occulta

20
Q

Lumbar Tap

Epidural block

A

Needle placed in subarachnoid space below L1 to anesthetize cauda equina roots bathed in cerebrospinal fluid

Needle placed below S1 where subarachnoid space ends and superificial to dura mater, sacral spinal nerves are anesthetized

21
Q

3 parts of somites

A

Sclerotome- vertebrae and parts of ribs
Myotome- striated musculature of the neck, trunk and extremities
Dermatome- subcutaneous tissue and skin

22
Q

Epimere/Hypomere

A

Epimere- dorsal, innervated by dorsal ramus of spinal nerve; form the extensors and rotators
Hypomere- ventral, innervated by ventral ramus; form the body wall and limb muscles

23
Q

Vertebral formation

A
  1. Sclerotome tissue surrounds neural tube and notochord by folding.
  2. Caudal and cranial segments of sclerotome separate
  3. Intersegmentation occurs as spinal nerve innervates the myotome.
  4. Muscles now are connected to 2 adjacent vertebra facilitating movement
24
Q

Gastrulation

A

Primitive Streak, Knot
Intraembryonic mesoderm- 4 columns
Connecting Stalk, Oral and Cloacal membranes
Cardiogenic plate- mesoderm

25
Q

When does patterning occur

A

Weeks 4-8
Primary Patterning- establishing the body axes
Secondary- Establishing regional or organ specific axes

26
Q

Anterior-posterior axis in the embryo

A

Hox-B expression determining veretebral type

27
Q

Dorsal-ventral axis in the CNS

A

Shh is secreted from notochord. Dorsal diffusion induces development of dorsal neural tube; Ventral neural tube forms motor neurons, dorsal neural tube forms sensory ganglia. Lateral diffusion affects adjacent somites. Ventral/medial somite becomes sclerotome, dorsal/lateral somite becomes dermomyotome

28
Q

Anterior-posterior axis in developing limbs

A

Shh is secreted from zone of polarizing activity, located in proximal-posterior part of limb bud. Greatest amount of Shh on posterior side

29
Q

Diseases
HOXD13

Sonic Hedgehog

Patched (receptor/repressor)

GLI3(transcription factor)

A

Synpolydactyly- polyalanine stretch of amino terminal region, causes the distal metacarpal bones to take on a more proximal phenotype
holoprosencephaly, abnormal septation of cerebral hemisphere
Basal cell nevus syndrome, calcifcation of cerebral hemisphere, predisposition to basal cell carcinoma
cephalopolysyndactyly or polydactyly

30
Q

Features of placenta- endometrium lining

A

Connecting stalk- connection between embryo and placenta; shifts during gastrulation
Smooth chorion- covers the amnion
Villous Chorion- anchoring villi (connect placenta to decidua basalis)/free villi
Cytotrophoblastic shell- interface of villous chorion and decidua basalis