Week 1 Flashcards
Age related Developmental Changes:
Replicative senescence
Theory states that cells can replicate or divide a specific number of times. This ability tends to decrease with age.
Age related Developmental changes:
Oxidative damage
The cumulative result of the aerobic metabolism, which generates chemicals called free radicals. Free radicals may interact with other chemicals in the body and cause damage to cells.
Age related Developmental changes:
Telomere shortening
A theory that links aging to a reduction in cell division.
Age related Developmental changes:
Weakening of the immune response
Leaves older adults more vulnerable to infection and debilitating diseases.
Age related Physiological Changes:
Integumentary System
Loss of dermal an epidermal thickness
Functional change:
Loss of subcutaneous tissue and then epidermidis.
Implications:
Prone to skin breakdown and injury
Age related Physiological Changes:
Integumentary System
Decreased vascularity
Functional change:
Atrophy of sweat glands resulting in decreased sweat production, decreased body odor, decreased heat loss, dryness
Implications:
Alteration in thermoregulatory response, fluid requirements may change seasonally, loss of skin water, increase risk of heat stroke
Age related Physiological Changes:
Respiratory System
Decreased lung tissue elasticity
Functional change:
Decreased vital capacity
Implications:
Reduce overall efficiency of ventilatory exchange
Age related Physiological Changes:
Respiratory System
Cilia atrophy
Functional change:
Change in mucociliary transport
Implications:
Increased Susceptibility to infection
Age related Physiological Changes:
Respiratory System
Decreased respiratory muscle strength
Functional change:
Reduced ability to handle secretions and reduced effectiveness against noxious foreign particles. Partial inflation of lungs at rest.
Implications:
Increased risk of atelectasis
Age related Physiological Changes:
Cardiovascular System
Heart valves thicken and become fibrotic
Functional change:
Reduced stroke volume, cardiac output; may be altered
Implications:
Decreased responsiveness to stress
Age related Physiological Changes:
Cardiovascular System
Fibroelastic thickening of the Sinoatrial (SA) node; decreased number of pacemaker cells
Functional changes:
Slower heart rate
Implications:
Increased prevalence of arrhythmias
Age related Physiological Changes:
Cardiovascular System
Decreased Baroreceptor sensitivity (stretch receptors)
Functional change:
Decrease sensitivity to changes in blood pressure
Implications:
Prone to loss of balance, which increases the risk for falls
Age related Physiological Changes:
Gastrointestinal System
Liver become smaller
Functional change:
Decreased storage capacity
Age related Physiological Changes:
Gastrointestinal System
Decreased muscle tone
Functional change:
Altered mobility
Implications:
Increase risk of constipation, functional bowel syndrome, esophageal spasm, diverticular disease
Age related Physiological Changes:
Gastrointestinal System
Decrease basal metabolic rate (rate at which fuel is converted into energy)
Implications:
May need fewer calories
Lab results: UA
Protein
Normal:
0-5mg/100ml
Changes with age:
Rises slightly
Comments:
May be due to kidney changes with age, urinary tract infection, renal pathology
Lab results: UA
Specific gravity
Normal:
1.005-1.020
Changes with age:
Lower max in elderly 1.016–1.022
Comments:
Decline in nephrons impairs ability to concentrate urine
Lab results: Hematology
ESR
Normal:
Men 0–20
Women 0–30
Changes with age:
Significant increase
Comments:
Neither sensitive nor specific in aged
Lab results: Hematology
Iron binding
Normal:
Men 50–160mcg/dl
Women 230-410mcg/dl
Changes with age:
Slight decrease
Decrease
Lab results: Hematology
Hemoglobin
Normal: 
Men 13-18g/100ml
Women 12-16g
Changes with age:
Men 10-17g
Women none noted
Comments:
Anemia common in the elderly
Lab results: Hematology
Hematocrit
Normal:
Men 45-52%
Women 37-48%
Changes with age:
Men slightly decreased
Women speculated
Comments:
Decline in hematopoiesisLeu
Lab results: Hematology
Leukocytes
Normal:
4,300-10,800/mm3
Changes with age:
Drop to 3,100-9,000/mm3
Comments:
Decrease may be due to drugs or sepsis and should not be attributed immediately to age
Lab results: Hematology
Lymphocytes
Normal:
00-2,400 T cells/mm3
50-200 B cells/mm3
Changes with age:
T-cell and B-cell levels fall
Comment:
Infection risk higher; immunization encouraged
Lab results: Hematology
Platelet
Normal:
150,000-350,000
Changes with age:
No change in number
Lab results: Blood chemistry
Albumin
Normal:
3.5-5.0
Changes with age:
Decline
Comments:
Related to decrease in liver size and enzymes; protein-energy malnutrition common
Lab results: Blood chemistry
Globulin
Normal:
2.3-3.5
Changes with age:
Slight increase
Lab results: Blood chemistry
Total serum protein
Normal:
6.0-8.4g
Changes with age:
No change
Comments:
Decrease may indicate malnutrition, infection, liver disease
Lab results: Blood chemistry
Blood urea nitrogen (BUN)
Normal:
Men 10-25mg
Women 8-20mg
Changes with age:
Increases significantly up to 69mg
Comments:
Increases significantly up to 69mg
Lab results: Blood chemistry
Creatinine
Normal:
0.6-1.5mg
Changes with age:
Increases to 1.9mg
Comments:
Related to lean body mass decrease
Lab results: Blood chemistry
Creatinine clearance
Normal:
104-124 mL/min
Changes with age:
Decreases 10%/decade after age 40 years
Comments:
Used for prescribing medications for drugs excreted by kidneys
Lab results: Blood chemistry
Glucose tolerance
Normal: 62-110mg/dL after fasting; >120mg/dL after 2hrs postprandial
Changes with age:
Slight increase of 10mg/dL/decade after 30 years of age
Comments:
Diabetes increasingly prevalent; Drugs may cause glucose intolerance
Lab results: Blood chemistry
Alkaline phosphatase
Normal:
13-39 IU/L
Changes with age:
Increased by 8-10 IU/L
Comments:
Elevations >20% usually due to disease; elevations may be found with bone abnormalities, drugs (narcotics), and eating a fatty meal
Atypical disease presentations:
Acute abdomen
Absence of symptoms or vague symptoms, Acute confusion, mild discomfort and constipation, some tachypnea and possibly vague respiratory symptoms, appendicitis pain may begin in right lower quadrant and become diffuse
Atypical disease presentations:
Depression
Anorexia, vague abdominal complaints, new onset of constipation, insomnia, hyperactivity, lack of sadness
Atypical disease presentations:
Hyperthyroidism
Hyperthyroidism presenting as “apathetic thyrotoxicosis,”i.e., fatigue and weakness; weight loss may result instead of weight gain; patient’s report palpitations, tachycardia, new onset of atrial fabulation, and heart failure may occur with undiagnosed hyperthyroidism
Atypical disease presentations:
Hypothyroidism
Hypothyroidism often presents with confusion and agitation; new onset of anorexia, weight loss, and arthralgias may occur
Atypical disease presentations:
Malignancy
New or worsening back pain secondary to metastasis from slow growing breast masses or silent masses of the bowel
Atypical disease presentations:
Myocardial infarction (MI)
Absence of chest pain.
Vague symptoms of fatigue, nausea, and a decrease in functional and cognitive status; classic presentations include dyspnea, epigastric discomfort, weakness, vomiting; history of previous cardiac failure.
Higher prevalence in females versus males. Non-Q-wave MI
Atypical disease presentations:
Overall infectious disease process
Absence of fever or low-grade fever.
Malaise.
Sepsis without usual leukocytosis and fever.
Falls, anorexia, new onset of confusion and/or alterations and change in mental status, decrease in usual functional status
Atypical disease presentations:
Peptic ulcer disease
Absence of abdominal pain, dyspepsia, early satiety
Painless, bloodless
New onset of confusion, unexplained tachycardia, and/or hypotension
Atypical disease presentations:
Pneumonia
Absence of fever; mild coughing without copious sputum, especially in dehydrated patients; tachycardia and tachypnea; anorexia and malaise are coming; alteration and cognition