Week 1 Flashcards

1
Q

Age related Developmental Changes:

Replicative senescence

A

Theory states that cells can replicate or divide a specific number of times. This ability tends to decrease with age.

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2
Q

Age related Developmental changes:

Oxidative damage

A

The cumulative result of the aerobic metabolism, which generates chemicals called free radicals. Free radicals may interact with other chemicals in the body and cause damage to cells.

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3
Q

Age related Developmental changes:

Telomere shortening

A

A theory that links aging to a reduction in cell division.

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4
Q

Age related Developmental changes:

Weakening of the immune response

A

Leaves older adults more vulnerable to infection and debilitating diseases.

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5
Q

Age related Physiological Changes:
Integumentary System

Loss of dermal an epidermal thickness

A

Functional change:
Loss of subcutaneous tissue and then epidermidis.

Implications:
Prone to skin breakdown and injury

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6
Q

Age related Physiological Changes:
Integumentary System

Decreased vascularity

A

Functional change:
Atrophy of sweat glands resulting in decreased sweat production, decreased body odor, decreased heat loss, dryness

Implications:
Alteration in thermoregulatory response, fluid requirements may change seasonally, loss of skin water, increase risk of heat stroke

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7
Q

Age related Physiological Changes:
Respiratory System

Decreased lung tissue elasticity

A

Functional change:
Decreased vital capacity

Implications:
Reduce overall efficiency of ventilatory exchange

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8
Q

Age related Physiological Changes:
Respiratory System

Cilia atrophy

A

Functional change:
Change in mucociliary transport

Implications:
Increased Susceptibility to infection

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9
Q

Age related Physiological Changes:
Respiratory System

Decreased respiratory muscle strength

A

Functional change:
Reduced ability to handle secretions and reduced effectiveness against noxious foreign particles. Partial inflation of lungs at rest.

Implications:
Increased risk of atelectasis

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10
Q

Age related Physiological Changes:
Cardiovascular System

Heart valves thicken and become fibrotic

A

Functional change:
Reduced stroke volume, cardiac output; may be altered

Implications:
Decreased responsiveness to stress

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11
Q

Age related Physiological Changes:
Cardiovascular System

Fibroelastic thickening of the Sinoatrial (SA) node; decreased number of pacemaker cells

A

Functional changes:
Slower heart rate

Implications:
Increased prevalence of arrhythmias

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12
Q

Age related Physiological Changes:
Cardiovascular System

Decreased Baroreceptor sensitivity (stretch receptors)

A

Functional change:
Decrease sensitivity to changes in blood pressure

Implications:
Prone to loss of balance, which increases the risk for falls

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13
Q

Age related Physiological Changes:
Gastrointestinal System

Liver become smaller

A

Functional change:

Decreased storage capacity

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14
Q

Age related Physiological Changes:
Gastrointestinal System

Decreased muscle tone

A

Functional change:
Altered mobility

Implications:
Increase risk of constipation, functional bowel syndrome, esophageal spasm, diverticular disease

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15
Q

Age related Physiological Changes:
Gastrointestinal System

Decrease basal metabolic rate (rate at which fuel is converted into energy)

A

Implications:

May need fewer calories

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16
Q

Lab results: UA

Protein

A

Normal:
0-5mg/100ml

Changes with age:
Rises slightly

Comments:
May be due to kidney changes with age, urinary tract infection, renal pathology

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17
Q

Lab results: UA

Specific gravity

A

Normal:
1.005-1.020

Changes with age:
Lower max in elderly 1.016–1.022

Comments:
Decline in nephrons impairs ability to concentrate urine

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18
Q

Lab results: Hematology

ESR

A

Normal:
Men 0–20
Women 0–30

Changes with age:
Significant increase

Comments:
Neither sensitive nor specific in aged

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19
Q

Lab results: Hematology

Iron binding

A

Normal:
Men 50–160mcg/dl
Women 230-410mcg/dl

Changes with age:
Slight decrease
Decrease

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20
Q

Lab results: Hematology

Hemoglobin

A

Normal: 
Men 13-18g/100ml
Women 12-16g

Changes with age:
Men 10-17g
Women none noted

Comments:
Anemia common in the elderly

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21
Q

Lab results: Hematology

Hematocrit

A

Normal:
Men 45-52%
Women 37-48%

Changes with age:
Men slightly decreased
Women speculated

Comments:
Decline in hematopoiesisLeu

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22
Q

Lab results: Hematology

Leukocytes

A

Normal:
4,300-10,800/mm3

Changes with age:
Drop to 3,100-9,000/mm3

Comments:
Decrease may be due to drugs or sepsis and should not be attributed immediately to age

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23
Q

Lab results: Hematology

Lymphocytes

A

Normal:
00-2,400 T cells/mm3
50-200 B cells/mm3

Changes with age:
T-cell and B-cell levels fall

Comment:
Infection risk higher; immunization encouraged

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24
Q

Lab results: Hematology

Platelet

A

Normal:
150,000-350,000

Changes with age:
No change in number

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25
Lab results: Blood chemistry Albumin
Normal: 3.5-5.0 Changes with age: Decline Comments: Related to decrease in liver size and enzymes; protein-energy malnutrition common
26
Lab results: Blood chemistry Globulin
Normal: 2.3-3.5 Changes with age: Slight increase
27
Lab results: Blood chemistry Total serum protein
Normal: 6.0-8.4g Changes with age: No change Comments: Decrease may indicate malnutrition, infection, liver disease
28
Lab results: Blood chemistry Blood urea nitrogen (BUN)
Normal: Men 10-25mg Women 8-20mg Changes with age: Increases significantly up to 69mg Comments: Increases significantly up to 69mg
29
Lab results: Blood chemistry Creatinine
Normal: 0.6-1.5mg Changes with age: Increases to 1.9mg Comments: Related to lean body mass decrease
30
Lab results: Blood chemistry Creatinine clearance
Normal: 104-124 mL/min Changes with age: Decreases 10%/decade after age 40 years Comments: Used for prescribing medications for drugs excreted by kidneys
31
Lab results: Blood chemistry Glucose tolerance
Normal: 62-110mg/dL after fasting; >120mg/dL after 2hrs postprandial Changes with age: Slight increase of 10mg/dL/decade after 30 years of age Comments: Diabetes increasingly prevalent; Drugs may cause glucose intolerance
32
Lab results: Blood chemistry Alkaline phosphatase
Normal: 13-39 IU/L Changes with age: Increased by 8-10 IU/L Comments: Elevations >20% usually due to disease; elevations may be found with bone abnormalities, drugs (narcotics), and eating a fatty meal
33
Atypical disease presentations: Acute abdomen
Absence of symptoms or vague symptoms, Acute confusion, mild discomfort and constipation, some tachypnea and possibly vague respiratory symptoms, appendicitis pain may begin in right lower quadrant and become diffuse
34
Atypical disease presentations: Depression
Anorexia, vague abdominal complaints, new onset of constipation, insomnia, hyperactivity, lack of sadness
35
Atypical disease presentations: Hyperthyroidism
Hyperthyroidism presenting as “apathetic thyrotoxicosis,”i.e., fatigue and weakness; weight loss may result instead of weight gain; patient’s report palpitations, tachycardia, new onset of atrial fabulation, and heart failure may occur with undiagnosed hyperthyroidism
36
Atypical disease presentations: Hypothyroidism
Hypothyroidism often presents with confusion and agitation; new onset of anorexia, weight loss, and arthralgias may occur
37
Atypical disease presentations: Malignancy
New or worsening back pain secondary to metastasis from slow growing breast masses or silent masses of the bowel
38
Atypical disease presentations: Myocardial infarction (MI)
Absence of chest pain. Vague symptoms of fatigue, nausea, and a decrease in functional and cognitive status; classic presentations include dyspnea, epigastric discomfort, weakness, vomiting; history of previous cardiac failure. Higher prevalence in females versus males. Non-Q-wave MI
39
Atypical disease presentations: Overall infectious disease process
Absence of fever or low-grade fever. Malaise. Sepsis without usual leukocytosis and fever. Falls, anorexia, new onset of confusion and/or alterations and change in mental status, decrease in usual functional status
40
Atypical disease presentations: Peptic ulcer disease
Absence of abdominal pain, dyspepsia, early satiety Painless, bloodless New onset of confusion, unexplained tachycardia, and/or hypotension
41
Atypical disease presentations: Pneumonia
Absence of fever; mild coughing without copious sputum, especially in dehydrated patients; tachycardia and tachypnea; anorexia and malaise are coming; alteration and cognition
42
Atypical disease presentations: Pulmonary edema
Lack of paroxysmal nocturnal dyspnea or coughing; insidious onset with changes in function, food or fluid intake, or confusion
43
Atypical disease presentations: Tuberculosis (TB)
Hepatosplenomegaly, abnormalities and liver function tests and anemia
44
Atypical disease presentations: Urinary tract infection
Absence of fever, worsening mental or functional status, dizziness, anorexia, fatigue, weakness
45
Geriatric syndromes: SPICES
``` S: sleep disturbances P: Problems with eating or feeding I: incontinence C: confusion E: evidence of falls  ```
46
Geriatric syndromes
Early detection and correction of problems such as sensory deficits, confusion, and gait/balance issues can increase independence and longevity among the elderly
47
Geriatric syndromes: Confusion (Delirium)
A state of unclear thinking caused by delirium and dementia Delirium is a state of mental confusion that develop suddenly and can fluctuate over time ``` D: drugs E: electrolyte imbalance L: lack of drugs (withdrawal, uncontrolled pain) I: infection (often UTI) R: reduce sensory input (vision or hearing loss) I: intracranial (CVA or subdural) U: urinary retention or fecal impaction M: myocardial/pulmonary ```
48
Categories of aging: Ranges
Young-old: 65-74 years Old: 75-84 years Oldest-old: 85 years and older
49
Categories of aging: Dermatological psoriasis
Younger adults: Late teens to 20s A regular course which tends to generalize hereditary factors Older adults: 50s: Males 60s: Females Sporadic onset
50
Categories of aging: | Gastrointestinal IBD, UC, CD
Younger adults: 20-40 years old Right lower UC ``` Older adults: > 60-75 years old a second peak occurs more often older women proctitis Left-sided UC higher rates of anemia may present as chronic diarrhea fistula development increased cases of associated malnutrition extraintestinal manifestations include arthritis spondylitis, Uveitis, and erythema nodosum, More comorbid conditions may be confused with other forms of colitis ```
51
Categories of aging: Malignancy
Younger adults: 20-30 years old Older adults: >50 years old
52
Categories of aging: Hodgkin’s lymphoma
Younger adults: Possible infectious ideology Older adults: Increased mortality
53
Categories of aging: Neurodegenerative myasthenia gravis
Young adults: Women 20-40 years old More thymus abnormalities ``` Older adults: Men 50-70 years old Woman 70 years old Dysphonia More frequent ocular form MG Increased rate of ACHR seropositivity ```
54
Exercise in older adults: Sleep and flexibility
To maintain the flexibility necessary for a regular physical activity in daily life, older adults should perform activities that maintain or increase flexibility on at least 2 days each week for at least 10 minutes each day
55
Exercise recommendations for specific diagnosis: Osteoarthritis
Walking, aquatic activities, tai chi, resistant exercises, cycling Vary type and intensity to avoid over stressing joints; heated pool
56
Exercise recommendations for specific diagnosis: Coronary artery disease
Walking, treadmill walking, cycle ergometry Supervised program with BP and HR monitoring
57
Exercise recommendations for specific diagnosis: Congestive heart failure
Walking, treadmill walking, cycle ergometry Individualized to client; supervised program
58
Exercise recommendations for specific diagnosis: Type 2 diabetes mellitus
Resistive, aerobic, aquatic, recreational activities  Proper shoe fit; may need insulin reduction if insulin dependent
59
Exercise recommendations for specific diagnosis: Anxiety disorder
Walking, biking, weightlifting If able to do high intensity exercise, this benefits anxiety
60
Exercise recommendations for specific diagnosis: Depression
Walking, cycling, recreational activities Group participation helpful to keep patient engaged
61
Exercise recommendations for specific diagnosis: Fibromyalgia
Aerobic, aquatic therapy, strengthening, tai chi, Pilates Heated pool, gentle stretches, counsel about possible increased pain initially
62
Exercise recommendations for specific diagnosis: Chronic obstructive pulmonary disease
Cycle ergometer, treadmill walking: individualize Supervised program-consider pulmonary rehab program
63
Exercise recommendations for specific diagnosis: Chronic venous insufficiency
Walking, standing exercises Supervised programs
64
Exercise recommendations for specific diagnosis: Osteoporosis
Weight-bearing exercises, weight training Assess balance and risk for falls before beginning
65
Exercise recommendations for specific diagnosis: Parkinson’s disease
Walking, treadmill walking, stationary bike, dancing, tai chi, Pilates, boxing Assess balance and risk for falls before beginning; American Parkinson’s disease Association resource
66
Exercise recommendations for specific diagnosis: Peripheral artery disease
Lower extremity exercises, treadmill walking, walking Very short intervals initially, progress as tolerated
67
Exercise recommendations for specific diagnosis: Age related sleep disorders
Tai chi, walking, aquatic therapy, biking Assess balance and risk for falls before beginning
68
Exercise recommendations for specific diagnosis: Dementia
Walking, recreational activities Provide safe environment, assess fall risk and ability to participate Testing prior to exercise initiation Recommended testing prior to exercise initiation
69
Recommended testing prior to exercise initiation
Assess balance and risk for falls
70
Barriers to exercise
Lack of time, perceived need for equipment, perceived barrier to begin exercise/physical activity, disability or functional limitation, unsafe neighborhood or weather conditions, no park or walking trails, depression, high body mass index, lack of motivation, enter personal loss or significant life event, ignorance of what to do
71
 patient facilitators to exercise
Social support, positive self-efficacy, Motivation to engage in physical activity, good health, no functional limitations, frequent contact with prescriber, regular schedule, plan program, satisfaction with program, insurance incentive, improvement in mobility or health condition, staff
72
Contraindications to exercise
Unstable angina, uncompensated heart failure, severe anemia, and controlled blood glucose, and stable aortic aneurysm, uncontrolled hypertension or tachycardia, severe dehydration or heat stroke, low oxygen saturation
73
Health promotion: immunizations Influenza
Recommended annually for all adults over 50 years old Unless contra indicated. Patients with a severe egg allergy or severe reaction to the influenza vaccination in the past with prior history of Guillain-Barré syndrome to talk to the healthcare provider before getting the vaccination 
74
Health promotion: immunizations Tetanus-diphtheria toxoids with pertussis vaccination (Tdap)
Once in a lifetime booster to adult then TD booster every 10 years
75
Health promotion: immunizations Pneumococcal vaccination
PCV 13 at the age of 65 | PPSV23 12months after PVC 13
76
Health promotion: immunizations Hepatitis B
Recommended for a high-risk person(I.e. Drug users, sexually active with multiple partners, living with someone with chronic happy, patients less than 60 years old with diabetes, and all desiring protection from Hep B) The initial dose is given followed one month later by second dose then their dose is given for six months after the second
77
Health promotion: immunizations Shingrix (zoster)
Administered and two doses Second dose is given 2 to 6 months after initial dose Persons who have had zostavax immunizations with shingrix
78
Recommended health screenings: Hearing loss
Greater than 50 years old
79
Recommended health screenings: HIV
15-65 years old
80
Recommended health screenings: Alcohol Misuse
Greater than 18 years old
81
Recommended health screenings: Tobacco abuse and depression
All adults
82
Recommended health screenings: Hypertension
Greater than 18 years old
83
Recommended health screenings: Abnormal blood glucose
40-70 years old who are overweight or obese
84
Recommended health screenings: Low-moderate dose statin for prevention of CVD without history of CVD or ischemic stroke
Who all is met: 40-75 years old One or more risk factor for CVD (Dyslipidemia, diabetes, hypertension, or smoking) Calculated 10 year risk of cardiovascular event of 10% or greater
85
Recommended health screenings: Abdominal aortic aneurysm
One time but ultrasound in men aged 65 to 75 years old who have ever smoked
86
Recommended health screenings: Obesity
All adults, refers BMI is greater than 30 or higher to intensive multi component behavioral interventions
87
Recommended health screenings: Mammogram
Biennial for women age 50 to 74 years old
88
Recommended health screenings: Visual acuity
Older adults
89
Recommended health screenings: Osteoporosis
Women age 65 and older Younger women whose fraction race is equal to or greater than that of a 65-year-old white woman who has no additional risk factors
90
Recommended health screenings: Prostate cancer
Older men
91
Recommended health screenings: Cognitive impairment
Older adults
92
Recommended health screenings: Colorectal cancer
Starting at age 50 and continuing until age 75
93
Risks related to travel
Patients with chronic disease that as well managed at home may decompensate and foreign environments because of heat, humidity, altitude, fatigue, changes in diet, and exposure to infectious diseases. Fever is not always reliable indication of illness and older adults Seroconversion rates decrease with age, rendering some vaccines less effective for older travelers
94
Immunizations for travel
All immunizations should be current: influenza, pneumococcal, TD/Tdap, zoster, and for some hepatitis B vaccination. Yellow fever and herpes Oster are the only life virus vaccines that people over the age 50 receive. A man response can be impaired if live virus vaccines are given within a 28 to 30 day interval from each other If a patient is required to have a yellow fever vaccine for travel, they can’t enter a yellow fever county until 10 days after receiving the yellow fever vaccine. The most common vaccine used for protecting travelers are hepatitis A, hepatitis B, typhoid fever, yellow fever, adult booster polio, Japanese encephalitis, meningococcal, and rabies
95
Comprehensive geriatric assessment: Purpose
Physical health is related to psychosocial, functional ability and safe environment Most beneficial for the vulnerable, older adult
96
Comprehensive geriatric assessment: Domain #1
Physical health History taking, physical exam, diagnostics, nutritional assessment, medication review (Cc, HPI, past history, family and social history, and ROS)
97
Comprehensive geriatric assessment: Domain #2
Functional health ADLs, instrumental activities of daily living, sensory assessment (hearing, vision) can I gait and balance Purpose determines how the older adult can care for themselves on a day-to-day basis Any change in function is often the first and only sign of a new or changed disease process (The Katz activities of daily living scale)
98
Comprehensive geriatric assessment: Domain # 3
Psychological health Cognitive disorders (delirium, dementia, mild cognitive impairment), Affective disorders (depression, anxiety), Spiritual well-being (MMSE, Montreal cognitive assessment (MoCA), and St. Louis University mental status examination (SLUMS))
99
Comprehensive geriatric assessment: Domain #4
Socioenvironmental support and quality of life measures Socioenvironmental: social network and support (The medical outcomes study—short-form 36) Supports: A living situation, environmental safety, economic resource (lubben social network scale) Quality of life measures: physical conditions, social conditions, environmental conditions, personal resources (mental health, life perspective), Preferences for care (The medical outcomes study— short-form 36)
100
Beers criteria: Purpose
Go to use for medical management of geriatric patients List of potentially inappropriate medication‘s for the elderly-listed by drug category and diagnosis List alternative drugs that can be used safely in older adults Drug to drug interactions listed, dosage for kidney impairment graded as high, medium, or low to assist with decision-making
101
Polypharmacy: Multiple definitions
Prescribing many drugs, prescribing five or more drugs, prescribing potentially inappropriate medication‘s The use of multiple pharmacies (providers and self-prescribers) Provider should routinely evaluate medication appropriateness to avoid the risk of polypharmacy
102
Polypharmacy: Prevention strategies
Have new patients bring in all medications to their first visit Review meds list at every visit Ask if any other provider has changed or added any medication‘s Update med list at every visit
103
Polypharmacy: Screening tools
Three available tools to evaluate patients prescriptions STOPP- screening tool of older persons potentially inappropriate prescriptions MAI- medication appropriateness index ARMOR- assess, review, minimize, optimize, reassess