Week 1 Flashcards
Age related Developmental Changes:
Replicative senescence
Theory states that cells can replicate or divide a specific number of times. This ability tends to decrease with age.
Age related Developmental changes:
Oxidative damage
The cumulative result of the aerobic metabolism, which generates chemicals called free radicals. Free radicals may interact with other chemicals in the body and cause damage to cells.
Age related Developmental changes:
Telomere shortening
A theory that links aging to a reduction in cell division.
Age related Developmental changes:
Weakening of the immune response
Leaves older adults more vulnerable to infection and debilitating diseases.
Age related Physiological Changes:
Integumentary System
Loss of dermal an epidermal thickness
Functional change:
Loss of subcutaneous tissue and then epidermidis.
Implications:
Prone to skin breakdown and injury
Age related Physiological Changes:
Integumentary System
Decreased vascularity
Functional change:
Atrophy of sweat glands resulting in decreased sweat production, decreased body odor, decreased heat loss, dryness
Implications:
Alteration in thermoregulatory response, fluid requirements may change seasonally, loss of skin water, increase risk of heat stroke
Age related Physiological Changes:
Respiratory System
Decreased lung tissue elasticity
Functional change:
Decreased vital capacity
Implications:
Reduce overall efficiency of ventilatory exchange
Age related Physiological Changes:
Respiratory System
Cilia atrophy
Functional change:
Change in mucociliary transport
Implications:
Increased Susceptibility to infection
Age related Physiological Changes:
Respiratory System
Decreased respiratory muscle strength
Functional change:
Reduced ability to handle secretions and reduced effectiveness against noxious foreign particles. Partial inflation of lungs at rest.
Implications:
Increased risk of atelectasis
Age related Physiological Changes:
Cardiovascular System
Heart valves thicken and become fibrotic
Functional change:
Reduced stroke volume, cardiac output; may be altered
Implications:
Decreased responsiveness to stress
Age related Physiological Changes:
Cardiovascular System
Fibroelastic thickening of the Sinoatrial (SA) node; decreased number of pacemaker cells
Functional changes:
Slower heart rate
Implications:
Increased prevalence of arrhythmias
Age related Physiological Changes:
Cardiovascular System
Decreased Baroreceptor sensitivity (stretch receptors)
Functional change:
Decrease sensitivity to changes in blood pressure
Implications:
Prone to loss of balance, which increases the risk for falls
Age related Physiological Changes:
Gastrointestinal System
Liver become smaller
Functional change:
Decreased storage capacity
Age related Physiological Changes:
Gastrointestinal System
Decreased muscle tone
Functional change:
Altered mobility
Implications:
Increase risk of constipation, functional bowel syndrome, esophageal spasm, diverticular disease
Age related Physiological Changes:
Gastrointestinal System
Decrease basal metabolic rate (rate at which fuel is converted into energy)
Implications:
May need fewer calories
Lab results: UA
Protein
Normal:
0-5mg/100ml
Changes with age:
Rises slightly
Comments:
May be due to kidney changes with age, urinary tract infection, renal pathology
Lab results: UA
Specific gravity
Normal:
1.005-1.020
Changes with age:
Lower max in elderly 1.016–1.022
Comments:
Decline in nephrons impairs ability to concentrate urine
Lab results: Hematology
ESR
Normal:
Men 0–20
Women 0–30
Changes with age:
Significant increase
Comments:
Neither sensitive nor specific in aged
Lab results: Hematology
Iron binding
Normal:
Men 50–160mcg/dl
Women 230-410mcg/dl
Changes with age:
Slight decrease
Decrease
Lab results: Hematology
Hemoglobin
Normal: 
Men 13-18g/100ml
Women 12-16g
Changes with age:
Men 10-17g
Women none noted
Comments:
Anemia common in the elderly
Lab results: Hematology
Hematocrit
Normal:
Men 45-52%
Women 37-48%
Changes with age:
Men slightly decreased
Women speculated
Comments:
Decline in hematopoiesisLeu
Lab results: Hematology
Leukocytes
Normal:
4,300-10,800/mm3
Changes with age:
Drop to 3,100-9,000/mm3
Comments:
Decrease may be due to drugs or sepsis and should not be attributed immediately to age
Lab results: Hematology
Lymphocytes
Normal:
00-2,400 T cells/mm3
50-200 B cells/mm3
Changes with age:
T-cell and B-cell levels fall
Comment:
Infection risk higher; immunization encouraged
Lab results: Hematology
Platelet
Normal:
150,000-350,000
Changes with age:
No change in number