WBC translocations/genetics to know

Question 1

CD34+

Answer 1

hematopoietic stem cell

Question 2

IL 5 stimulates

Answer 2

eosinophils

Question 3

IL6 stimulates

Answer 3

plasma cells

Question 4

basophils increased in ?

Answer 4

CML

Question 5

lymphoma with eosinophils?

Answer 5

Hodgkin lymphoma

Question 6

+MPO?

+tDt?

Answer 6

myeloblasts/auer rods

lymphoblasts

Question 7

t(12:21)

Answer 7

B-ALL with good prognosis

Question 8

t(9,22)

Answer 8

philadelphia ch — bcr-abl fusion = increased tyrosine kinase activity = overgrowth
ALL with poor prognosis
CML

Question 9

markers for B-ALL?

Answer 9

CD 19, 10, 22, PAX5

Question 10

markers for T-ALL?

Answer 10

CD1-8, tDT, and NOTCH1

Question 11

t(15,17)

Answer 11

retinoic acid receptor
AML
APL

Question 12

leukemia in:
down syndrome kids >5?
down syndrome kids

Answer 12

> 5 —- ALL

Question 13

smudge cells?

Answer 13

CLL

Question 14

coexpression for CD5 and CD20?

Answer 14

CLL

Question 15

richter transformation?

Answer 15

CLL –> DLBCL

Question 16

trap + and CD11C?

Answer 16

hairy cell leukemia

Question 17

pautrier microabcesses?

Answer 17

aggregates in skin of CD4 = mycosis fungoides

Question 18

3 conditions with JAK 2 kinase mutations?

Answer 18

myeloproliferative disorders:
polycythemia vera
essential thrombocythemia
myelofibrosis

Question 19

t(14, 18)

Answer 19

overexpression of bcl2 = inhibits apoptosis

follicular lymphoma

Question 20

t(11,14)

Answer 20

mantle cell lymphoma

cyclin D1 overexpressed = G1/S transition and proliferation

Question 21

t(8, 14)

Answer 21

burkitt lymphoma

cmyc overexpression = growth

Question 22

reed Sternberg cells

Answer 22

owl eye appearance

Hodgkin lymphoma

Question 23

RANK involvement?

Answer 23

multiple myeloma –> osteoclasts cause lytic lesions

Question 24

birbeck granules

Answer 24

tennis rackets = Langerhans cell histiocytosis

CD1a+ and S100+