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GI part 2 > WBC translocations/genetics to know > Flashcards

WBC translocations/genetics to know Flashcards

1
Q

CD34+

A

hematopoietic stem cell

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2
Q

IL 5 stimulates

A

eosinophils

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3
Q

IL6 stimulates

A

plasma cells

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4
Q

basophils increased in ?

A

CML

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5
Q

lymphoma with eosinophils?

A

Hodgkin lymphoma

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6
Q

+MPO?

+tDt?

A

myeloblasts/auer rods

lymphoblasts

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7
Q

t(12:21)

A

B-ALL with good prognosis

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8
Q

t(9,22)

A

philadelphia ch — bcr-abl fusion = increased tyrosine kinase activity = overgrowth
ALL with poor prognosis
CML

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9
Q

markers for B-ALL?

A

CD 19, 10, 22, PAX5

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10
Q

markers for T-ALL?

A

CD1-8, tDT, and NOTCH1

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11
Q

t(15,17)

A

retinoic acid receptor
AML
APL

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12
Q

leukemia in:
down syndrome kids >5?
down syndrome kids

A

> 5 —- ALL

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13
Q

smudge cells?

A

CLL

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14
Q

coexpression for CD5 and CD20?

A

CLL

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15
Q

richter transformation?

A

CLL –> DLBCL

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16
Q

trap + and CD11C?

A

hairy cell leukemia

17
Q

pautrier microabcesses?

A

aggregates in skin of CD4 = mycosis fungoides

18
Q

3 conditions with JAK 2 kinase mutations?

A

myeloproliferative disorders:
polycythemia vera
essential thrombocythemia
myelofibrosis

19
Q

t(14, 18)

A

overexpression of bcl2 = inhibits apoptosis

follicular lymphoma

20
Q

t(11,14)

A

mantle cell lymphoma

cyclin D1 overexpressed = G1/S transition and proliferation

21
Q

t(8, 14)

A

burkitt lymphoma

cmyc overexpression = growth

22
Q

reed Sternberg cells

A

owl eye appearance

Hodgkin lymphoma

23
Q

RANK involvement?

A

multiple myeloma –> osteoclasts cause lytic lesions

24
Q

birbeck granules

A

tennis rackets = Langerhans cell histiocytosis

CD1a+ and S100+

GI part 2 (8 decks)

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