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HandL Final > wbc, leukemia, lymphoma - hubbard > Flashcards

wbc, leukemia, lymphoma - hubbard Flashcards

1
Q

Tell me the Rai stage: lymphocytosis (ALC > 10,000) + anemia (Hg < 11)

A

3

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2
Q

5q- seen in what?

A

MDS

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3
Q

what chromosome is the BCL2 gene on?

A

18

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4
Q

what are AR conditions in SCN?

A

Kostmann HAX2

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5
Q

rituximab used to treat what? targets what?

A

ONLY B-cell lymphoma CD20

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6
Q

Auer rods pathognomic for what?

A

AML

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7
Q

back pain, leg edema can suggest what?

A

retroperitoneal LN enlargement

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8
Q

cause of hereditary neutrophilia? Inheritance?

A

mutated GCSF3 AD

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9
Q

what drug most commonly causes leukocytosis? what else?

A

corticosteroids Beta-agonists, Lithium

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10
Q

smudge cells

A

CLL

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11
Q

distended neck veins and veins distended in the upper chest is a classic picture of what? best imaging for it?

A

superior vena cava syndrome CT chest

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12
Q

what 2 things can treat APL (M3)?

A

all-trans retinoic acid (ATRA) arsenic trioxide

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13
Q

what can cause delayed separation of the umbilical cord?

A

leukocyte adhesion deficiency

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14
Q

describe LNs in lymphomas? pain can occur after what?

A

non-tender, rubbery beer drinking in HL

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15
Q

cause of Pelger-Huet? Morphology?

A

mutated Lamin B clumped chromatin w/in bilobed nucleus

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16
Q

lymphocytosis defined as what? due to what?

A

lymphocytes > 5,000 EBV, hepatitis, Bartonella h.

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17
Q

Ann Arbor Stage? LN region involved

A

1

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18
Q

acute febrile neutrophilic dermatosis (AFND) is known as what? what manifestation? treatment?

A

Sweet’s syndrome, cutaneous Manage AML

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19
Q

what is an Ommaya reservoir? used for what?

A

catheter inserted into lateral ventricle w/sq reservoir delivery of intrathecal therapies

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20
Q

gingival hypertrophy is most commonly seen in what leukemias?

A

AMML (M4) Acute monocytic Leukemia (M5)

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21
Q

Tell me the Rai stage: lymphocytosis (ALC > 10,000) + hepatosplenomegaly

A

2

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22
Q

standard of tx for pt under 70 in CLL?

A

fludarabine plus rituximab, w/or w/out cyclophosphamide

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23
Q

t(8;21) seen in what?

A

M1 and M2 (most common) AML

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24
Q

The Rai staging system is for what? treatment is based on what?

A

CLL Stage

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25
inversion of ch. 16 seen in what?
MDS M2 AML
26
eosinophilia defined as what? due to what?
\> 400 (IL-5) FIPIL1-PDGFRA mutation
27
schistocytes are seen in what conditions?
microangiopathic hemolytic anemias like TTP and HUS
28
what diseases have ALK(+)?
t-cell lymphoma lung cancer
29
remnants of the mitotic spindle, see in old rbcs are called what?
Cabot rings
30
what leukemias often present with bone pain?
acute leukemias, esp ALL
31
what is the most common mutation in SCN? inheritance
ELANE AD
32
Episodic fevers, rash, conjuctivitis, muscle and skin tenderness is what disease? mutation?
familial cord uticaria CIAS1, Decreased C1-esterase inhibitor
33
absolute lymphocyte count \> 5,000 means what?
CLL
34
radiation is associated with all leukemias except what?
CLL
35
LAD-1 due to mutation of what? LAD-2?
fucked B chain of Beta2 integrin, LOF in LFA-1 neuts lack sialyl Lewis X (L-selectin ligand)
36
Ann Arbor Stage? A subtype? B subtype?
A - lack constitutional symptoms B - have "B symptoms"
37
what occurs in 35% of pts with ALL manifested by diplopia? treatment?
leptomeningeal carcinomatosis intrathecal methotrexate
38
what pts are at increased risk for primary CNS lymphoma?
immunosuppresssed (HIV, organ transplant)
39
68 y/o woman presents w/painless swelling in groin, no other complaints or symptoms, main diagnosis?
indolent lymphoma shes old
40
t(12;21) seen in what?
ALL
41
hydroxyurea is used to treat what?
myeloproliferative disorders, CML
42
t(15;17) pathognomic for what? what fusion gene?
APL PML-RARa
43
Ann Arbor Stage? disseminated disease with extranodal involvement OR bone marrow involvement
4
44
t(6;9) is what?
aggressive lymphoma/leukemia
45
vincristine w/prednisone used to treat what?
ALL
46
what is associated with a better prognosis in ALL?
hyperdiploidy of 4, 10, 17 t(12;21)
47
7q- seen in what?
MDS
48
Tell me the Rai stage: lymphocytosis (ALC \> 10,000) + LAD
1
49
what environmental exposure is associated with AML? what drugs?
benzene doxorubicin, adriamycin
50
what defines a leukemoid rxn? what infections can cause it?
WBC \> 50,000 C diff, Tb
51
what clinical feature of SCN is the following describing: neutrophils \< 200 that lasts 3-5 days, occurs at 21-day intervals w/recurrent fevers, mouth sores, skin infections, uri's, om?
cyclic neutropenia
52
what is the best option for obtaining a tissue diagnosis in superior vena cava syndrome?
mediastinoscopy
53
Ann Arbor Stage? LN regions involved on both sides/(above and below) of diaphragm
3
54
2-chlorodeoxyadenosine is treatment for what?
hairy cell leukemia
55
t(4; 11) seen in what?
L2 ALL
56
tear drop cell pathology of what condition?
myelophthisis (metastatic cancer, fibrosis, granulomatous disease)
57
Tell me the Rai stage: lymphocytosis only (ALC \> 10,000)
0
58
Severe congenital neutropenia may progress to what? count of what?
MDS, AML \< 500 neuts
59
if untreated, the median duration of survival for adult acute leukemia is what?
3 months or less
60
faggot cells seen in what?
APL
61
what is the treatment for pts with stage 1 or 2 HL?
radiation therapy
62
Decitabine is used to treat what?
MDS
63
what value is low in DIC? what is high?
fibrinogen D-dimer
64
Down syndrome has a 10% association w/what? can progress to what? due to what?
Transient myeloproliferative disorder (TMD) acute megakaryoblastic leukemia (AMKL) mutated GATA1
65
trisomy 8 seen in what? prognosis?
MDS better
66
Tell me the Rai stage: lymphocytosis (ALC \> 10,000) + thrombocytopenia (\< 100,000)
4
67
Ann Arbor Stage? involvement of 2 or more noncontiguous LN regions on 1 side of diaphragm
2
68
treatment for AML?
anthracycline (rubicin) + cytarabine
69
what are the 3 main B symptoms? what prognosis?
fever, drenching night sweats, 10% weight loss worse
70
1st line chemo treatment for HL?
Eric Berry Did Beat VD Doxorubicin bleomycin vinblastine dacarbazine

HandL Final (8 decks)

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