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HandL Final > wbc, leukemia, lymphoma - hubbard > Flashcards

wbc, leukemia, lymphoma - hubbard Flashcards

1
Q

Tell me the Rai stage: lymphocytosis (ALC > 10,000) + anemia (Hg < 11)

A

3

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2
Q

5q- seen in what?

A

MDS

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3
Q

what chromosome is the BCL2 gene on?

A

18

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4
Q

what are AR conditions in SCN?

A

Kostmann HAX2

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5
Q

rituximab used to treat what? targets what?

A

ONLY B-cell lymphoma CD20

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6
Q

Auer rods pathognomic for what?

A

AML

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7
Q

back pain, leg edema can suggest what?

A

retroperitoneal LN enlargement

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8
Q

cause of hereditary neutrophilia? Inheritance?

A

mutated GCSF3 AD

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9
Q

what drug most commonly causes leukocytosis? what else?

A

corticosteroids Beta-agonists, Lithium

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10
Q

smudge cells

A

CLL

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11
Q

distended neck veins and veins distended in the upper chest is a classic picture of what? best imaging for it?

A

superior vena cava syndrome CT chest

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12
Q

what 2 things can treat APL (M3)?

A

all-trans retinoic acid (ATRA) arsenic trioxide

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13
Q

what can cause delayed separation of the umbilical cord?

A

leukocyte adhesion deficiency

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14
Q

describe LNs in lymphomas? pain can occur after what?

A

non-tender, rubbery beer drinking in HL

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15
Q

cause of Pelger-Huet? Morphology?

A

mutated Lamin B clumped chromatin w/in bilobed nucleus

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16
Q

lymphocytosis defined as what? due to what?

A

lymphocytes > 5,000 EBV, hepatitis, Bartonella h.

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17
Q

Ann Arbor Stage? LN region involved

A

1

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18
Q

acute febrile neutrophilic dermatosis (AFND) is known as what? what manifestation? treatment?

A

Sweet’s syndrome, cutaneous Manage AML

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19
Q

what is an Ommaya reservoir? used for what?

A

catheter inserted into lateral ventricle w/sq reservoir delivery of intrathecal therapies

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20
Q

gingival hypertrophy is most commonly seen in what leukemias?

A

AMML (M4) Acute monocytic Leukemia (M5)

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21
Q

Tell me the Rai stage: lymphocytosis (ALC > 10,000) + hepatosplenomegaly

A

2

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22
Q

standard of tx for pt under 70 in CLL?

A

fludarabine plus rituximab, w/or w/out cyclophosphamide

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23
Q

t(8;21) seen in what?

A

M1 and M2 (most common) AML

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24
Q

The Rai staging system is for what? treatment is based on what?

A

CLL Stage

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25
Q

inversion of ch. 16 seen in what?

A

MDS M2 AML

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26
Q

eosinophilia defined as what? due to what?

A

> 400 (IL-5) FIPIL1-PDGFRA mutation

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27
Q

schistocytes are seen in what conditions?

A

microangiopathic hemolytic anemias like TTP and HUS

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28
Q

what diseases have ALK(+)?

A

t-cell lymphoma lung cancer

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29
Q

remnants of the mitotic spindle, see in old rbcs are called what?

A

Cabot rings

30
Q

what leukemias often present with bone pain?

A

acute leukemias, esp ALL

31
Q

what is the most common mutation in SCN? inheritance

A

ELANE AD

32
Q

Episodic fevers, rash, conjuctivitis, muscle and skin tenderness is what disease? mutation?

A

familial cord uticaria CIAS1, Decreased C1-esterase inhibitor

33
Q

absolute lymphocyte count > 5,000 means what?

A

CLL

34
Q

radiation is associated with all leukemias except what?

A

CLL

35
Q

LAD-1 due to mutation of what? LAD-2?

A

fucked B chain of Beta2 integrin, LOF in LFA-1 neuts lack sialyl Lewis X (L-selectin ligand)

36
Q

Ann Arbor Stage? A subtype? B subtype?

A

A - lack constitutional symptoms B - have “B symptoms”

37
Q

what occurs in 35% of pts with ALL manifested by diplopia? treatment?

A

leptomeningeal carcinomatosis intrathecal methotrexate

38
Q

what pts are at increased risk for primary CNS lymphoma?

A

immunosuppresssed (HIV, organ transplant)

39
Q

68 y/o woman presents w/painless swelling in groin, no other complaints or symptoms, main diagnosis?

A

indolent lymphoma shes old

40
Q

t(12;21) seen in what?

A

ALL

41
Q

hydroxyurea is used to treat what?

A

myeloproliferative disorders, CML

42
Q

t(15;17) pathognomic for what? what fusion gene?

A

APL PML-RARa

43
Q

Ann Arbor Stage? disseminated disease with extranodal involvement OR bone marrow involvement

A

4

44
Q

t(6;9) is what?

A

aggressive lymphoma/leukemia

45
Q

vincristine w/prednisone used to treat what?

A

ALL

46
Q

what is associated with a better prognosis in ALL?

A

hyperdiploidy of 4, 10, 17 t(12;21)

47
Q

7q- seen in what?

A

MDS

48
Q

Tell me the Rai stage: lymphocytosis (ALC > 10,000) + LAD

A

1

49
Q

what environmental exposure is associated with AML? what drugs?

A

benzene doxorubicin, adriamycin

50
Q

what defines a leukemoid rxn? what infections can cause it?

A

WBC > 50,000 C diff, Tb

51
Q

what clinical feature of SCN is the following describing: neutrophils < 200 that lasts 3-5 days, occurs at 21-day intervals w/recurrent fevers, mouth sores, skin infections, uri’s, om?

A

cyclic neutropenia

52
Q

what is the best option for obtaining a tissue diagnosis in superior vena cava syndrome?

A

mediastinoscopy

53
Q

Ann Arbor Stage? LN regions involved on both sides/(above and below) of diaphragm

A

3

54
Q

2-chlorodeoxyadenosine is treatment for what?

A

hairy cell leukemia

55
Q

t(4; 11) seen in what?

A

L2 ALL

56
Q

tear drop cell pathology of what condition?

A

myelophthisis (metastatic cancer, fibrosis, granulomatous disease)

57
Q

Tell me the Rai stage: lymphocytosis only (ALC > 10,000)

A

0

58
Q

Severe congenital neutropenia may progress to what? count of what?

A

MDS, AML < 500 neuts

59
Q

if untreated, the median duration of survival for adult acute leukemia is what?

A

3 months or less

60
Q

faggot cells seen in what?

A

APL

61
Q

what is the treatment for pts with stage 1 or 2 HL?

A

radiation therapy

62
Q

Decitabine is used to treat what?

A

MDS

63
Q

what value is low in DIC? what is high?

A

fibrinogen D-dimer

64
Q

Down syndrome has a 10% association w/what? can progress to what? due to what?

A

Transient myeloproliferative disorder (TMD) acute megakaryoblastic leukemia (AMKL) mutated GATA1

65
Q

trisomy 8 seen in what? prognosis?

A

MDS better

66
Q

Tell me the Rai stage: lymphocytosis (ALC > 10,000) + thrombocytopenia (< 100,000)

A

4

67
Q

Ann Arbor Stage? involvement of 2 or more noncontiguous LN regions on 1 side of diaphragm

A

2

68
Q

treatment for AML?

A

anthracycline (rubicin) + cytarabine

69
Q

what are the 3 main B symptoms? what prognosis?

A

fever, drenching night sweats, 10% weight loss worse

70
Q

1st line chemo treatment for HL?

A

Eric Berry Did Beat VD Doxorubicin bleomycin vinblastine dacarbazine

HandL Final (8 decks)

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