WBC Disorders Flashcards
Presence of toxic granulation and Dohle bodies are seen in ___
infections
Name the disorder:
BCR-ABL fusion gene
Chronic Myeloid Leukemia
Causes dysregulated production and uncontrolled proliferation of mature and maturing granulocytes w fairly normal differentiation
Most common leukemia in adults in Western hemisphere
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Which of the following is NOT a feature of CML?
A. Many don’t have symptoms
B. Fatigue, night sweats, weight loss
C. Macrocytic anemia
D. Absolute basophilia, eosinophilia, neutrophilia
E. Hepato/splenomegaly
F. High platelet count
C. Normocytic normochromic anemia
T/F: CML is cured w/ Tyrosine kinase inhibitors (Gleevac)
False. Not curative
Only cured w/ allogenic stem cell transplant
T/F: CML has poor survival rate.
False. Very good long term survival
Which of the following is/are curable with chemotherapy? A. CML B. CLL/SLL C. ALL D. AML
C, D
> 20% lymphoblasts in bone marrow/peripheral blood is diagnostic of ___
Acute Lymphocytic Leukemia
> 20% myeloid blasts in bone marrow/peripheral blood is diagnostic of ___
Acute Myeloid Leukemia
UNLESS pt has one of 4 cytogenetic abnormalities
T/F: CNS and testicular involvement is typically seen in Acute Myeloid Leukemia
False. Acute Lymphocytic Leukemia
AML hardly have CNS or testicular involvement
Name the disease:
Auer rods on blood smear
Acute Myeloid Leukemia
T/F: Hepato/splenotomegaly is more common in AML than ALL and is most common in CML
False. More common in ALL than AML
True most common in CML: 50-90% sm, 50% hm
Name the disease:
Most common acute leukemia in adults
Acute Myeloid Leukemia
Median age of AML
65
Median age of ALL
Most common in kids
14
Median age of CML
50-60
Median age of CLL/SLL
72
T/F: CLL is predominately in bone marrow and SLL is predominately in lymph nodes. Other than that, they consist of the same cells.
True
Genetics is a very small risk factor of _____.
AML
Main RF: • Exposure to: Benzene Ionizing radiation Chemotherapy
Leukemia infiltration in gums, CNS, skin commonly seen in ___
AML
95% of pts have circulating blasts in ____
AML
T/F: Pts with CLL are more likely to get leukostasis
False. Most likely in AML
T/F: Pt with Chronic Myeloid Leukemia does not need treatment if he is asymptomatic.
False. True for Chronic Lymphocytic Leukemia