WBC disorders

Question 1

Normal WBC count ____ (# and units)

Answer 1

5-10k

Question 2

Low WBC aka ___?

Answer 2

leukopenia

Question 3

High WBC aka ___?

Answer 3

Leukocytosis

Question 4

Hematopoietic stem cell (HSC) has CD___?

Answer 4

34

Question 5

2 causes of neutropenia (not genetic)

Answer 5

Drug toxicity - chemo (targets fast dividing cells)
Severe infection (neutrophils goes into tissue = less in blood)
Treat with GM CSF, G CSF

Question 6

lymphopenia causes

Answer 6

Immunodeficiency (DiGeorge, HIV)
High cortisol state - apoptosis in lymphocytes
Autoimmune destruction
Whole body radiation (lymphocytes esp sensitive to radiation)

Question 7

Neutrophilic leukocytosis causes

Answer 7

Bacterial infection/tissue necrosis - induce release of marginating pool/bone marrow neutrophils
High cortisol state - impair leukocyte adhesion

Question 8

Immature neutrohils characterize by decreased _____?

Answer 8

CD16 - FcR

Question 9

Basophilia highly correlates with ___?

Answer 9

CML

Question 10

Eosinophilia caused by ___, ____, ___

Answer 10

Allergic reaction (type 1 hypersensitivity), parasitic infection, Hodgkin lymphoma