Water Soluble Vitamins Flashcards

1
Q

What type of thiamin deficiency is associated with tender calf muscles?

A

Wet adult Beriberi

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2
Q

What are the sources of thiamin?

A

Pork and whole grain

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3
Q

What are the forms of thiamin?

A

TDP and TTP

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4
Q

What coenzyme related to thiamin is important for the reaction of pyruvate to acetyl CoA?

A

TDP

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5
Q

TTP is important in what body system?

A

Nervous system

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6
Q

What is TTP specifically important for in the nervous system?

A

Sodium-Chloride transport

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7
Q

Wernicke-Korsakoff Syndrome is limited to what group of people?

A

Alcoholics

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8
Q

What form of Beriberi is associated with an enlarged heart in adults?

A

Wet

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9
Q

What form of Beriberi is associated with geriatrics?

A

Dry

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10
Q

Acute Beriberi is associated with what population?

A

Babies

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11
Q

What is vitamin B1?

A

Thiamin

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12
Q

What is the vitamin associated with ascorbic acid/ascorbate?

A

Vitamin C

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13
Q

What are the functions of vitamin C?

A

Antioxidant, nonheme iron absorption, collagen

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14
Q

What step of collagen formation is vitamin C important for?

A

Hydroxylation

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15
Q

What are the sources of vitamin C?

A

Ascorbic acids (citrus) and peppers

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16
Q

What condition is a deficiency of vitamin C?

A

Scurvy

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17
Q

What are the four “H’s” of scurvy?

A

1 Hemorrhagic
2 Hematologic
3 Hyperkeratosis
4 Hyperchondriasis

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18
Q

What is a symptom of vitamin C toxicity?

A

Diarrhea

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19
Q

What is B2?

A

Riboflavin

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20
Q

What are the forms of riboflavin?

A

Coenzymes FAD and FMN

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21
Q

What are the sources of riboflavin?

A

Dairy products, dark green leafy vegetables, and whole grains

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22
Q

FAD and FMN are important or the synthesis of what B vitamins?

A

Niacin and B6

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23
Q

Riboflavin (FAD and FMN) is important in what biochemical cycles?

A

Electron transport chain, Krebs Cycle, Beta-oxidation

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24
Q

FAD and FMN are important for what group of enzymes?

A

Dehydrogenases

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25
Q

What mouth condition is specific to ariboflavinosis?

A

Magenta tongue

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26
Q

What mouth conditions are seen with ariboflavinosis?

A

1 Cheilosis
2 Angular stomatitis
3 Glossitis
4 Magenta Tongue

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27
Q

Besides mouth conditions, what other symptom can be seen with ariboflavinosis?

A

Dermatitis

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28
Q

What is B5?

A

Pantothenic acid

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29
Q

What are the forms of vitamin B5?

A

CoA and Acyl carrier protein (ACP)

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30
Q

The CoA function of pantothenic acid is important in what biochemistry cycles?

A

Krebs Cycle and Beta-oxidation

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31
Q

What is the condition of pantothenic acid deficiency?

A

Burning feet syndrome

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32
Q

What are sources of pantothenic acid?

A

Whole grains, legumes, and meat

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33
Q

What is the Acyl carrier protein function of pantothenic acid important for?

A

Lipid synthesis

34
Q

What is B7?

A

Biotin

35
Q

Biotin deficiency is most likely seen in what population?

A

Pregnant women

36
Q

What are symptoms of biotin deficiency?

A

Dermatitis, glossitis, increased cholesterol

37
Q

What are the sources for biotin?

A

Large intestinal bacteria, dairy, and nuts

38
Q

Biotin is bound to what structure?

A

Carboxylases

39
Q

An important chelator for biotin is found in what food source?

A

Raw eggs

40
Q

What is vitamin B3?

A

Niacin

41
Q

Niacin is made from what substance?

A

Tryptophan

42
Q

What are the forms of niacin?

A

NAD and NADPH for dehydrogenase reactions

43
Q

Niacin is important in dehydrogenase reactions in which biochemical cycles?

A

Glycolysis, Krebs, and Beta-oxidation

44
Q

NADPH is important for the synthesis of what substances?

A

Fatty acids, triglycerides, and cholesterol

45
Q

What are sources of niacin?

A

Meat

46
Q

What is the condition of niacin deficiency?

A

Pellagra

47
Q

What are the symptoms of pellagra?

A

Dermatitis, diarrhea, dementia (sometimes death)

48
Q

What are the issues with niacin deficiency?

A

Liver damage (leading to gout) and flushing

49
Q

What is B6?

A

Pyridoxine

50
Q

What are sources of B6?

A

Meat and whole grains

51
Q

Vitamin B6 is important for the synthesis of what substances?

A

Neurotransmitters, myelin sheath, heme

52
Q

What is the form of vitamin B6?

A

PLP

53
Q

What is PLP (B6) important for?

A

Amino acid metabolism

54
Q

Vitamin B6 is important for the synthesis of what other B vitamin?

A

Niacin (B3)

55
Q

Both deficiency and toxicity of which vitamin leads to peripheral neuropathy?

A

Vitamin B6 (Pyridoxine)

56
Q

What are the symptoms of vitamin B6 deficiency?

A

Fatigue and peripheral neuropathy

57
Q

What is vitamin B12?

A

Cobalamin

58
Q

What are the sources of cobalamin?

A

Meat, fish, and dairy

59
Q

What are the two main conditions of thiamin deficiency?

A

Wernicke-Korsakoff and Beriberi

60
Q

What enzymes are responsible for the digestion of vitamin B12?

A

Proteases

61
Q

What is the function of adenosylcobalamin?

A

Amino acid metabolism

62
Q

What is the function of methylcobalamin?

A

Myelination and decreased homocysteine

63
Q

What conditions arise from vitamin B12 deficiency?

A

Megaloblastic anemia, pernicious anemia

64
Q

What binds to cobalamin in the stomach?

A

R protein

65
Q

Where does R protein (which binds to cobalamin in the stomach) come from?

A

Saliva

66
Q

What binds to cobalamin in the small intestine?

A

Intrinsic factor

67
Q

By what process is cobalamin absorbed?

A

Receptor mediated endocytosis

68
Q

Vitamin B12 is transported via what structures?

A

Transcobalamins

69
Q

Where is cobalamin stored?

A

Liver

70
Q

Receptor mediated endocytosis and therefore cobalamin absorption is decreased in what kinds of patients?

A

Those with pancreatic insufficiency and/or malabsorption issues

71
Q

Where is intrinsic factor released from?

A

Parietal cells of the stomach

72
Q

Cobalamin absorption can become impaired from what kinds of conditions that specifically inhibit intrinsic factor release?

A

Zollinger-Ellison and reflux disease

73
Q

What is vitamin B9?

A

Folate

74
Q

What is the synthetic form of folate?

A

Folic acid

75
Q

What are the sources for folate (B9)?

A

Dark green leafy vegetables and legumes

76
Q

What are the sources for folic acid?

A

Supplements and fortified cereals

77
Q

What can result from folate deficiency?

A

Neural tube defects, megaloblastic anemia

78
Q

Folic acid decreases the absorption of what mineral?

A

Zinc

79
Q

What mineral is required for the absorption of folate?

A

Zinc

80
Q

What is the form and function of folate?

A

THF (methylation)

81
Q

What is THF important for (folate)?

A

Synthesis of DNA/RNA, red blood cells, and white blood cells