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Neet Pg > Water Soluble Vitamins > Flashcards

Water Soluble Vitamins Flashcards

1
Q

Vit B1-thiamine

A

Enzymes-ATP
Alpha keto glutarate dehydrogenase
Transketolase
Pyruvate dehydrogenase
Seen diet rich in polished rice

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2
Q

Vit B1 def causes

A

Beri-beri
Wet, dry
High output heart failure leads to edema

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3
Q

Vit B2 -riboflavin

A

Part fad/fadh2
Succinate dehydrogenase
Glutathione reductase
Def causes angular chelitis, corneal neovascularisation

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4
Q

Vit B3-Niacin

A

Function -NAD/NADH
Niacin is made in body from tryptophan
60mg—>1mg niacin
With the help of B6 or B2

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5
Q

Vit B3 def

A

Pellegra
3D dermatitis, diarrhoea, dementia
Casals necklace

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6
Q

Niacin def also seen in

A

Hartnub disease
Maize rich diet
Serotonin syndrome
Drugs-INH

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7
Q

Niacin excess symptoms

A

Flushing
Inc levels of uric acid
Hyperlipidemia

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8
Q

Vit B5 -panthothenic acid def causes

A

Alopecia
Dermatitis- burning foot syndrome
Enteritis

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9
Q

Vit B6 pyridoxine def

A

Peripheral neuropathy
Neonatal seizures
Sideroblastic anemia

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10
Q

Vit B6 functions

A

Decarboxylations
Heme synthesis
ALT or AST
Deficiency caused by drugs
INH, OCP

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11
Q

Vit B7 biotin def

A

Seen in raw white egg which is rich in avidin
C/f alopecia dermatitis

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12
Q

Hematinic vitamin

A

Folate B9, vit B12

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13
Q

B9 and B12 def causes

A

Megaloblastic and pancytopenia

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14
Q

Vit c functn

A

Hydroxylation of lysine/proline in collagen.
Anti-O2
Absorption of iron

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15
Q

Vit c

A

Hydroxylation of lysine/proline in collagen.
Anti-O2
Absorption of iron

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16
Q

Vit c def

A

Scurvy
Bleeding gums
Painful joints
Petechiae

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17
Q

Scurvy x ray features

A

Subperiosteal hemorrhage
Scorbitic zone
Dense zone of provisional calcification
Ring epiphysis
Pelken spur

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18
Q

7 dehydrochlesterol present in

A

Skin

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19
Q

25 oH hydroxylase present in

A

Liver

20
Q

7 dehydro cholesterol ->cholecalciferol in?

A

Skin

21
Q

Storage form of vit D

A

25-OH calciferol

22
Q

25-OH calciferol converted to 1,25 oH calciferol with the help of

A

1alpha hydroxylase

23
Q

Parathyroid causes hypophosphatemia how??

A

With the help of FGF23 -phosphate excretion

Inactivation of vit d

24
Q

Causes of rickets

A

Vit d def
Ckd
Micellaneous

25
Q

C/f of rickets

A

Craniotabes- ping, pong skull
Delayed dentition
Chest -rachitic rosary
Harrison sulcus
Pectus carinatum
Genu varum
Genu valgum
Wind swept deformity

26
Q

Inv of rickets

A

Calcium decreased
PTH-inc
Po4 - decreased
ALP-inc
25 OH vit D3 always low

27
Q

X ray rickets finding

A

Loss of provisional zone of calcification early sign
Cupping
Fraying
Splaying

28
Q

High dose reg for rickets

A

STOSS
60k iu/wk×6-10 wk

29
Q

Response check after ??

A

4 weeks by using x ray of wrist
White line of calcification -positive

30
Q

Vddr type 1

A

Defect-1alpha hydroxylase
Rx -1,25 oH calciferol

31
Q

Vddr 2

A

Defect in vit d receptor
AR
Syndromic:rickets+oligodontia/milia/ ectodent defect
Poor prog
Rx high dose ca

32
Q

Hypophosphatemic rickets

A

Rickets +ectodermal defect
X linked dominant
Mutn-PHEX codes for endopeptidase which converts active FGF23 to inactive that won’t occur
PTH level normal/dec slightly
Rx-joue soln contains po4
Mab-Burosumab

33
Q

Def vit A causes

A

Toad like dry skin - phrynoderma

34
Q

Vit A def eye wHO classification

A

X1A-conjunctival xerosis
X1B-Bitots spot
X2 -corneal sclerosis
X3A -corneal ulcer(<1/3)
X3B->1/3 rd of surface area
XF - fundal change
XS scarring

35
Q

Vit A def Tx

A

Vit A 3 dose 0,1,14
<6m-50k iu/day
6-12m-1lac iu/dose
>12 m-2lac iu /dose

36
Q

Vit k function

A

Gamma carboxylation of factors 2,7,9,10

37
Q

Vit k administration at birth

A

> 1kg -1mg
<1kg-0.5 mg

38
Q

Vit E def causes

A

Hemolytic anemia
Spinocerebellar ataxia

39
Q

Vit A excess causes

A

Teratogenic
Pseodo cereberi

40
Q

Vit d excess

A

Calcinosis

41
Q

Vit E excess

A

Thrombocyopenia

42
Q

Vit k excess

A

Nnj

43
Q

Zn function

A

Immunity, ep integrity, reproductive, anti oxidant

44
Q

Acrodermatitis enteropathica

A

AR
Mutation in SLC39A4

45
Q

Selenium def causes

A

Keshan d/s-cardiomyopathy

Neet Pg (5 decks)

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