Water Soluble Vitamins Flashcards
what fat soluble vitamin requirement is conditional
Vit D (sunlight exposure)
What are the water soluble vitamins
B1, B2, B3, B5, B6, B7, B9, B12, and C
what is the only water soluble vitamin stored in appreciable quantities in body tissues
B12
what must happen with all other water soluble vitamins
must be supplies in diet on day to day basis
how is water soluble vit requirement met in ruminants
microbial synthesis in rumen and lower GI tracts
where does microbial synthesis occur in herbivores (horse and rabbit)
colon or cecum
what is the structure of B complex vit
organic and unrelated
what animals do need dietary water soluble vit
non ruminants (pigs, poultry) and humans
what do B complex vit have role in
cell metabolism
do nutritionist have to worry about provided water soluble vit for ruminants and non-ruminant herbivores
no
what do B complex vit serve as
Coenzymes/ Cofactors
what is the requirement of B complex vit
minute amounts
what happens if B complex vit are unavailable to tissues in sufficient amounts
produce profound dysfunction in metabolism
is toxicity likely in B complex vit
very unlikely
what are plant sources of B1
outer layers of seeds/germs, growing roots leaves and shoots, fermented products
why is toxicity of B complex unlikley
readily excreted by kidney
what is chemical name of B1
Thiamin
What happens can happen in B1 deficiencies
loss of appetite, bradycardia/myocardial damage, enlarges adrenal glands
what are the different forms of B1
thiamin pyrophosphate and thiamin triphosphate
what are animal sources of B1
egg yolk, liver, kidney, pork
what biochemical reactions is B1 involved in
carbohydrate/AA catabolism and activation of chloride ion channel in membrane of nerves
what happens in B1 deficiency when there is loss of appetite
muscular weakness/NS dysfunction
what happens in B1 deficiency when there is bradycardia/myocardial damage
Dilated cardiomyopathy (DCM) and Heart failure (HF)
what happens in B1 deficiency when there is enlarged adrenal glands
hypothermia since adrenal glands aid in thermoregulation
What is a human disease caused by a deficiency in B1 called in humans
Beriberi
what causes beriberi in humans
diets high in white rice, alcoholism, poor absorption (rare)
clinical signs of wet beriberi
increased heart rate, shortness of breath, swelling of legs
clinical signs of dry beriberi
numbness in hands and feet, confusion
what is B1 deficiency marked by in poultry
decrease in appetite
what are the initial stages of B1 deficiency in poultry
lethargy and head tremors
when do neuro signs develop in B1 deficiency in poultry
3 weeks after initial stages
what are examples of neuro signs in B1 deficiency in poultry
sitting on flexed legs (star gazing position), retraction of head b/c paralysis of anterior neck muscles, lost ability to stand/sit upright
when is B1 deficiency in poultry most common
when poorly processed fish meals are used (thiaminase enzymes)
what is important about thiaminases heat sensitivity
cooking foods with them destroys anti-thiamin activity
what are the thiaminase enzymes in fish and sea foods and what makes them important
split thiamin molecule rendering it biologically ineffective
what is important about B1 in ruminants
microbial synthesis is usually sufficient
when are ruminants predisposed to bacterial thiaminases
lactic acidosis and polioencephalomalacia
what are clinical signs of bacterial thiaminases in ruminants
circling and head pressing
what does bacterial thiaminases result from
feeding rapidly fermentable foods
what predisposes horses to dietary thiaminases
Bracken fern (plant that renders thiamin inactive)