Water Balance Flashcards
1
Q
Name the two cell types in the collecting duct
A
principle cells and intercalated cells
2
Q
How does ADH work?
A
bind to V2 receptors (GPCR) on the basolateral membrane, activate adenylate cyclase, which produces cAMP which signals to protein kinase A to phosphorylate AQP2 channels and insert them into the apical membrane
3
Q
Give examples of situations when water retention would occur and ADH levels increase
A
hypoxia, hypercapnia, nausea, increased temperature (pyrogens)
4
Q
What does Na+ reabsorption favour?
A
K+ secretion
