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CRRAB II- Week 2 > Warren- Renal Tumors > Flashcards

Warren- Renal Tumors Flashcards

1
Q

What are the two benign renal tumors?

A

angiomyolipoma

oncocytoma

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2
Q

What is an angiomyoplipoma composed of?

A

VESSELS
SMOOTH MSUCLE
FAT

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3
Q

What is angiomyolipoma associated with?

A

Tuberus sclerosis

Autosomal dominant

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4
Q

A big mahogany brown tumor may be…

A

oncocytoma

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5
Q

What is seen microscopically in an oncocytoma?

A

large
EOSINOPHILIC CELLS w/
round nuclei

abundant mitochondria

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6
Q

Where do most oncocytoma arise from?

A

collecting duct

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7
Q

What percent of renal neoplasms are oncocytomas?

A

5-15%

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8
Q

What is the most common important risk factor for renal cell carcinoma?

A

tobacco use

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9
Q

What constitutes 85% of renal cancer in adults?

A

Renal cell carcinoma

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10
Q

What is Von hippel lindau syndrome?

A

Autosomal dominant
Hemangioblasoma of cerebellum/retina
renal cysts/renal carcinoma

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11
Q

What is the defect in VHLS?

A

VHL gene>
encodes protein of ubiquitin ligase complex (targets proteins for degradation)>
proteins that increase trx/promote angiogenesis aren’t degraded

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12
Q

What is the most common type of renal cell carcinoma?

A

Clear cell

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13
Q

What chromosome abnormality is associated w/ Clear cell?

A

loss of chromosom 3p

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14
Q

What does a clear cell tumor look like?

A

BRIGHT YELLOW tumor

Abundant clear/granular cytoplasm

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15
Q

What is papillary carcinoma?

A

10-15% of RCC

Papillary growth pattern and foam cells in papillary core

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16
Q

What is a chromophobe carcinoma?

A

Vegetable like cells with PROMINENT CELL MEMBRANES

17
Q

Where do RCCs usually grow?

A

Often invade the RENAL VEIN

18
Q

What is hte calssic presentation for RCC?

A

Only seen in 10% of pts: flank pain, palpable mass, hematuria

USUALLY asymptomatic for a long time

19
Q

A pt presents w/ polycythemia, hypercalcemia, HTN, hepatic dysfunction, feminization/masculinization. What might they have?

A

RCC which commonly causes PARANEOPLASTIC SYNDROMES

20
Q

What percent of RCC pts have metastasis at presentation and what is hte most common met location?

A

25%

Lung, then bone

21
Q

How do urothelial carcinomas present?

A

Usually arise in the renal pelvis>
Often multiple>
Early hematuria

CRRAB II- Week 2 (9 decks)

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