Warfarina Flashcards

1
Q

Mecanismo de acción

A

Antaginista de la vitamina K.
Disminución de los factores II, VII, IX, X (1972).

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1
Q

Indicaciones

A

TVP
EP
FA
IAM
Inmovilización prolongada
Prótesis valvulares cardíacas

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2
Q

Efectos adversos

A

Hemorragia
Necrosis cutanea
Sx del dedo hemorragico
Hepatotoxicidad
Alteraciones Gi
Teratogenicidad

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3
Q

Contraindicaciones

A

Hipersensiblidad
Hemorragias
Embarazo
Coagulopatias
IH o IR grave

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4
Q

Interacciones que aumentan

A

Inhibidores del CYP 450
- ABx
- Antidepresivos
- Amiodarona
- Antimicoticos
- Jugo de toronja

Paracetamol
Sulfunilureas
Alcohol

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5
Q

Interacciones que disminuyen

A

Inducotres de CYP 450
- Rifampicina, fenitoina, carbamazepina, barbituicos, griseofulvina, gengibre, regaliz.

Alimentos ricos en K
IBPS
Colestiramina

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