warfarin Flashcards
1
Q
can you use warfarin when breast-feeding?
A
yes
2
Q
factors that may potentiate warfarin
A
liver disease
P450 inhibitors (stop it being metabolised):
amiodarone, ciprofloxacin, cranberry juice
(sat OMION, havin a CIP of my cranberry juice, preparing myself to inhibit that enzyme + keep my drugs in my system)
NSAIDs (displace warfarin from albumin + inhibit platelet function)
3
Q
major bleeding on warfarin - management
A
major bleeding on warfarin is an indication for PCC
stop warfarin
IV vit K
PCC
4
Q
minor bleeding on warfarin - management
A
stop warfarin
IV vit K
restart when INR < 5
