Ward 6 Flashcards

1
Q

How many values are find in ABGs?

A

Six:
pH
PaO2
PaCO2
HCO3 (bicarbonate)
SaO2
BE (base excess)

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2
Q

What do ABGs try to tell us?

A

ABGs tell us about activity in two systems; the respiratory system and the ‘metabolic’ system. If one system is disturbed, the other tries to restore balance. Both systems are primarily concerned with keeping blood pH in the normal range. Even for the respiratory system, pH (rather than oxygen) is the priority

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3
Q

What are the main steps to take when looking at ABGs?

A

1- Look at pH
2- Look at PaCO2
3- Look at the base picture
4- Look at oxygen

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4
Q

What should you do when looking for pH in ABGs?

A

Decide whether this is an ‘acidosis’ or ‘alkalosis’ (if it is within the normal range, note whether it is sitting towards the ‘acidotic’ or ‘alkalotic’ end of that range)

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5
Q

Normal pH ABG

A

7.35 and 7.45.

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6
Q

What should you do when looking at PaCO2 in ABG?

A
  • Ask the question: is the PaCO2 contributing to, or attempting to compensate for, the problem. If, for example, the problem is an acidosis and the PaCO2 is low, then clearly the respiratory system is attempting to compensate. Thus, one can conclude that the problem is metabolic (similarly with other combinations). Therefore, after looking at only two numbers (pH and PaCO2), most of the interpretation is done.
  • The other numbers (actual bicarbonate [aHCO3], base excess [BE], PaO2 and so on) might do nothing more than confirm this conclusion. However, they can sometimes add information about time course or provide information on additional derangements, but they will not contradict the conclusion that has already been reached
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7
Q

What should you do when looking at the base picture in ABG?

A

Actual bicarbonate (aHCO3) vs standard bicarbonate (sHCO3) – what’s the difference? What is perhaps surprising is that, after many years of looking at ABGs, those intelligent, enquiring minds have seemingly never once pondered that question.

aHCO3 is the actual measurement of bicarbonate in that actual blood sample (hence the name). The problem with this measurement is that it is markedly affected by PaCO2. If the PaCO2 is high, the aHCO3 is dragged higher and vice versa. What one would like to know is what the HCO3 would have been had the PaCO2 been normal. It is this value that would provide a direct handle on what the metabolic system is doing. One can calculate the value if aHCO3 and PaCO2 are known, although most blood gas machines do this automatically, known as the sHCO3

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8
Q

What is base excess?

A

Base excess (BE) measures all bases, not just bicarbonate. However, because bicarbonate is the greater part of the base buffer, for most practical interpretations, BE provides essentially the same information as bicarbonate. In simple terms, a high BE excess is the same as a high HCO3

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9
Q

Normal level for base excess?

A

One could probably have guessed that the expected value of BE was zero (the clue is in the word: ‘excess’). Therefore, a tight range around zero (−3 to +3) is normal

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10
Q

Normal PaCO2

A

35-45 mm Hg

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11
Q

Normal PaO2

A

75-100 mm Hg

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12
Q

Interpret this ABG

A
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13
Q

What is type 2 respiratory failure?

A
  • Type 2 respiratory failure is extremely an issue of ventilation, that is, the business of pumping air in and out of the lungs. When underventilation occurs, for what ever reason (eg muscular weakness or opiate overdose), the PaCO2 will increase (the definition of underventilation) and PaO2 must decrease (even if the lungs are perfectly healthy).
  • Type 2 respiratory failure results from underventilation, which can occur even in the context of healthy lungs
  • defined as an increase in arterial carbon dioxide (CO2) (PaCO)> 45 mmHg with a pH < 7.35 due to respiratory pump failure and/or increased CO2 production
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14
Q

Respiratory failure types

A

Type 1, type 2, or type1+2

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15
Q

What is type 1 resp failure?

A

An acute type of resp failure with the distinguishing characteristic being a partial pressure of oxygen (PaO2) < 60 mmHg with a normal or decreased partial pressure of carbon dioxide (PaCO2)

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16
Q

Another name for type 2 resp failure

A

Hypercapnic resp failure

17
Q

V/Q mismatch etiologies

A

Etiologies of V/Q mismatch include:
- Acute respiratory distress syndrome
- Chronic obstructive pulmonary disease
- Congestive heart failure
- Pulmonary embolism

17
Q

Type 1 resp failure etiologies

A

Depending on the cause of hypoxemia, the alveolar-arterial (A-a) gradient may be normal or increased
Etiologies of Type 1 respiratory failure with normal A-a gradients include:
- Alveolar hypoventilation
- Low atmospheric pressure(such as high altitudes)/fraction of inspired oxygen
Etiologies of Type 1 respiratory failure with increased A-a gradients include:
- Diffusion defect (emphysema or interstitial lung disease)
- Ventilation/perfusion (V/Q) mismatch
- Right-to-left shunt

18
Q

Right to left shunt etiologies

A

Arteriovenous malformation
Complete atelectasis
Severe pneumonia
Severe pulmonary edema

19
Q

Type 2 resp failure etiologies

A
  • Respiratory pump failure
  • Increased dead space:
  • Increased CO2 production
  • Alveolar hypoventilation:
20
Q

What is the respiratory pump?

A

The respiratory pump is comprised of the chest wall, the pulmonary parenchyma, the muscles of respiration, as well as the central and peripheral nervous systems

21
Q

Reasons for respiratory pump failure

A
  • Decreased central dive
  • Altered neural and neuromuscular transmission
  • Chest wall and pleural disorders
  • Dead space ventilation
  • Muscle abnormalities
22
Q

Reasons for respiratory pump failure due to neural and neuromuscluar transmission

A

Amyotrophic lateral sclerosis, botulism, Guillain-Barre syndrome, myasthenia graves, organophosphate poisoning, poliomyelitis, spinal cord injury (SCI), tetanus, and transverse myelitis may impair the function of the respiratory pump, resulting in hypoventilation.

22
Q

Reasons for decreased central drive

A

Sedatives (i.e., alcohol, benzodiazepines, and opiates) and diseases of the central nervous system (i.e., encephalitis, stroke, tumor, and SCI) may impair the respiratory drive, resulting in hypoventilation

23
Q

Reasons for respiratory pump failure due to chest wall and pleural disorders

A

Flail chest, kyphoscoliosis, hyperinflation, large pleural effusions, obesity, and thoracoplasty may impair the function of the respiratory pump, resulting in hypoventilation

24
Q

Reasons for respiratory pump failure due to dead space ventilation

A

Conditions that increase the V/Q ratio, such as acute respiratory distress syndrome, bronchitis, bronchiectasis, emphysema, and pulmonary embolism, can result in hypoventilation

25
Q

When does hypoventilation occur in the setting of dead space ventilation

A

Hypoventilation typically occurs once dead space ventilation exceeds 50% of total ventilation.

26
Q

Reasons for respiratory drive failure due to muscle abnormalities

A

Diaphragmatic paralysis, diffuse atrophy, muscular dystrophy, and ruptured diaphragm may impair the function of the respiratory pump, resulting in hypoventilation.

27
Q

Settings where we find increased CO2 productions

A

CO2 is a by-product of oxidative metabolism, and high CO2 production may occur due to fever, exercise, hyperalimentation, sepsis, and thyrotoxicosis. High CO2 production becomes pathologic if the compensatory increase in minute ventilation mechanism fails.

28
Q

What is dead space when referring to the lung?

A

Dead space (VD) refers to areas of the lung that are not anatomically or physiologically able to exchange gas