W8 Mood and depression Disorders Flashcards
What is depression
Low mood, sleeping less/more, eating less/more, loss of interest, hopelessness.
How to measure depression
Self-report scales
Causes of depression
Life events, genetics, chemical imbalance in the brain.
What are the symptoms of depression
Cognitive symptoms: difficulty with concentration or making decisions.
Behavioral symptoms: social withdrawal and agitation.
Somatic (physical) symptoms: insomnia or hypersomnia, eating too much too little.
Affective (mood) symptoms: depressed mood and feelings of worthlessness or guilt.
Reactive depression
triggered by a negative experience
Endogenous depression
no apparent negative life event
Unipolar affective disorder
depression
Bipolar affectve disorder
depression with periods of mania (energetic, impulsive, positive, very confident). Very cyclic, you might spend months in the mania period and then go through depressive period.
Iproniazid
originally developed to treat tuberculosis (didn’t work!) but patients felt less depressed about having tuberculosis.
Mono amine oxidase (MAO)
is an enzyme that breaks down monoamine neurotransmitters. MAO inhibitors stop it working. Leaves more neurotransmitter in the neuron so more can be released
What chemical structure is part of tricyclic antidepressants?
Imipramine: chemical structure includes a three-ring chain.
Tricuclic antidepressants
block reuptake and therefore leaves more transmitter at the synapse.
Prozac
blocks reuptake and therefore leave more transmitter at the synapse.
What is used to treat bipolar
Lithium: interferes with second messenger system
Monoamine theory of depression
Anti-depressants act on monoamines. Hypothesis: Depression is actually caused by a deficit of monoamine neurotransmission
Some evidence of elevated receptors in depressed patients (to compensate for low levels of transmission)