W3 Acid Base (Bill) Flashcards

1
Q

Acid mnemonic

A

Respiratory = opposite
Metabolic = equal

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2
Q

Respiratory acidosis
Which electrolyte imbalance will you see?
How will the patient present?

A

Caused by ALVEOLAR HYPOVENTILATION
Lungs fail to expel CO2 and it accumulates in blood
CO2 reacts with H2O to form carbonic acid which dissociates into H+ and HCO3-
The increased H+ leads to a drop in PH and ACIDOSIS

Causes a lot of arterial dilation — BP drops
Low cardiac output — decreased squeeze, low peripheral resistance
These patients are “shock like” — give vasopressin, if it’s not working, the patient is acidosis, they don’t respond.
Have to correct the acidosis before the medication will work

Hyperkalemia — Why? H+ moves from Extracellular into intercellular, pushed K+ out of the cell. Causes hyperkalemia.

Muscle weakness, myoclonus.

Venous blood gas: check for pH
Arterial: CO2 and bicarb levels

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3
Q

What causes hypoventilation?

A

AIRWAY OBSTRUCTION: bronchitis, emphysema, bronchospasm
PULMONARY DISEASE (impaired gas exchange): fibrosis, PNA
RESPIRATORY DEPRESSION: anesthesia, sedatives, cerebral trauma
EXTRAPULMONARY THORACIC DISEASE: kyphosis, scoliosis, flail chest,
obesity
NEUROLOGIC DISEASE: polio

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4
Q

Respiratory alkalosis
Caused by?
Loss of _____ from the body
Leads to decrease of _____
Forces the kidneys to compensate and decrease _____

A

Caused by ALVEOLAR HYPERVENTILATION
-Excess loss of CO2 from body
-Leads to decreased formation of carbonic acid and decreased release of H+
-This increases the pH forcing the kidneys to compensate by decreasing HCO3-

Causes of increased respiratory drive: NORMAL COMPENSATORY RESPONSE:
1. ⭐️Hypoxia⭐️
a. PE
b. High altitude
c. Anemia

ABNORMAL COMPENSATORY RESPONSE
2. Anxiety
3. Salicylate Overdose
4. Brain Tumor

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5
Q

Some causes of respiratory alkalosis

A

P: panic attack A: anxiety S: salicylate overdose T: tumor P: pulmonary embolism H: hypoxia/high altitude

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6
Q

Respiratory alkalosis symptoms

A

—seizures
—low or normal BP, usually fine
—HYPOkalemia
—numbness and tingling

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7
Q

Metabolic acidosis
What is this?
How does the body compensate?

A

Caused the excess accumulation of organic acids in the body
-Increased production or ingestion
-Unable to eliminate the acid
-Excess HCO3- loss from the kidneys or GI tract

Leads to decreased HCO3- in blood (< 20 meq/L) and the pH falls < 7.35

The body hyperventilates to eliminate CO2 (compensatory)

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8
Q

How do you calculate the anion gap
What is high?
What is normal?

A

Sodium - chloride - CO2/HCO3
High is >12 mEq/L
Normal is <12

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9
Q

High anion gap : Excess H+
What is the mnemonic

A

*1. Increased Organic Acid Production:**
a. LACTIC ACIDOSIS: decreased oxygen delivery to tissues causes increased anaerobic metabolism and increased lactic acid
b. DIABETIC KETOACIDOSIS: lack of insulin causes cells to use fats as energy (instead of glucose) and the breakdown of fats produces keto acids

2. Failure of kidney to excrete organic acids:
a. Chronic Renal Failure: buildup of uric acids (uremia)

3. Ingestion:
a. Oxalic acid from ethylene glycol (anti-freeze)
b. Formic acid from methanol
c. Salicylate overdose
d. Paraldehyde (anti-epilepsy, old med)

4. Increased anaerobic metabolism and lactic acid production
a. Propylene glycol (paint)
b. Iron or Isoniazid overdose

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10
Q

What does MUD PILES stand for?

A
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11
Q

Metabolic acidosis and normal anion gap?
3 causes

A

DECREASED HCO3- OFFSET BY INCREASED OR BUILDUP OF CHLORIDE ION TO MAINTAIN THE ANION GAP Causes:

1. SEVERE DIARRHEA:
—intestinal secretions pass through GI tract prior to reabsorption

2. RENAL TUBULAR ACIDOSIS:
a. Type II: proximal convoluted tubule can’t reabsorb HCO3- and the pH decreases b. Other types of RTA: inability to excrete H+ in the urine

3. ADDISON’S DISEASE:
—don’t produce enough steroid hormones including
aldosterone.
—Aldosterone typically causes the distal collecting duct to secrete H+ ions and reabsorb Na.
When insufficient, retain H+ in blood.
a. Spironolactone: blocks aldosterone receptor

4. ACETAZOLAMIDE: decrease HCO3- reabsorption in the proximal trouble causing HCO3- wasting

5. TOTAL PARENTERAL NUTRITION: accumulation of H+ ions

6. SALINE INFUSION: IV saline has a pH of 5.5 therefore can get an accumulation of H+ ions

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12
Q

Normal anion gap mnemonic
HARD-ASS

A

Hyperalimentation
Addison’s disease
Renal tubular acidosis
Diarrhea
Acetazolamide
Spironolactone
Saline infusion

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13
Q

Metabolic acidosis

A

—headache
—decreased BP
—hyperkalemia
—warm, flushes kin,
—NVD
—changes in LOC
—kussmaul respirations

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14
Q

Metabolic alkalosis

A

Caused by:
1. Loss of excess H+ (by GI tract or kidneys) resulting in
increased HCO3- production

  1. Increased HCO3 Overall, the increased HCO3- increases pH and causes alkalosis

LOSS OF H+ IONS
1. From the GI tract: vomiting causes loss of stomach acid (H+ ions)
2. From the Kidneys (urine)
a. Conn’s Syndrome/Hyperaldosteronism: Aldosterone causes the sodium retention, the excretion of H+ ions into the urine, and reabsorption of HCO3-. This makes
the urine more acidic and the blood more alkaline.

INCREASED HCO3-
3. Volume contraction or contraction alkalosis: from loop diuretics
4. Ingested: antacids

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15
Q

Causes of metabolic alkalosis

A

LAVA

Loop diuretics
Antacids
Vomiting
Aldosterone increase

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16
Q

Know this summary of metabolic issues

A
17
Q

Potassium in alkalosis
Potassium in acidosis

A
18
Q

Hyperkalemia

A

Increased extracellular potassium reduces myocardial excitability with depression of both pacemaking and conduction tissues

Progressively worsening hyperkalemia leads to suppression of impulse generation by the SA node and reduced conduction by the AV node and His-Purkinje system, resulting in bradycardia, conduction blocks, and ultimately cardiac arrest.

Tip: After the initial T wave changes, the usual order of EKG changes seen in hyperkalemia follows logically and moves forward from the p wave, to the pr interval, and subsequently to the QRS complex with QRS widening and conduction blocks

19
Q

Which potassium level might manifest as peaked T waves?When do you see bradyarrhythmias?

A

5-6
7-9 bradyarrhythmias

20
Q

Hypokalemia

A

Decreased extracellular potassium causes myocardial hyperexcitability with the potential to develop reentrant arrhythmias

Can cause VT

Hypokalemia creates the illusion that the T wave is “pushed down” with resultant T wave flattening (or inverting), ST depression, and prominent U wave.

Can go into torsades

21
Q

Summary of hypo and hyper kalemia

A