W11 - Encoding Valence 1/2 Flashcards
What is the main argument of James-Lange theory of emotion?
These theories suggested that the relationship between bodily experience & emotional experience is flipped
On what observation about anxiety is based the paper of Hsueh et al.?
anxiety causes increased heart rate (emotional states influence bodily physiology)
How are Hsueh et al. modulating the mice heart rate?
Optogenetics via ChRmine expression (highly-sensitive red-shifted pump-like channelrhrodopsin) targeted to cells that express mTNT i.e. cardiomyocytes (with viral packaging in an AAV9 viral serotype)
What have Hsueh et al. observed in the EPM and OFT when they increased heart rate?
Anxiety-like behaviour in both tests
What have Hsueh et al. concluded about the ability of cardiac stimulation to induce anxiety?
Increasing heart rate increases anxiety in contexts that would normally induce anxiety (by default)
What was the effect of increasing heart rate in a place paradigm experiment?
No diff but not a priori stressful
How did Hsueh et al. identify the brain regions involved in the anxiety response to an increased heart rate?
Activity-dependent labelling + clarity process
How did Hsueh et al. show that the posterior insular cortex is required for the anxiogenic effect in response to an increase in heart rate, but not the prefrontal cortex?
Photoinhibition of regions identified with the labelling + clarity process.
