W10

Question 1

Factors affecting solubility

Answer 1

Crystal/solid properties
Solvent properties
Solute solvent interactions
Ionisation state
Molecular size
Temperature

Question 2

Stronger interactions =

Answer 2

Higher melting point = lower solubility

Question 3

The stronger the interactions the greater the…

Answer 3

Work

Question 4

Dissolving a solid

Answer 4

Not a single step

must remove a solute molecule

Then create a solvent cavity

Then incorporate the solute into the solvent

Question 5

Method to increase solubility

Answer 5

Co Solvency
Drug complexation
Salt formation
PH
Drug structure modification

Question 6

Factors that influence dissolution rate

Answer 6

Molecular diffusion
Solution stirring
Particle size
Temperature

Question 7

What does the diffusion coefficient reflect?

Answer 7

How quickly a molecule diffuses in a solution

Molecules move faster get dissolved faster

Question 8

Stoke Einstein equation

Answer 8

D = RT / 6πnaNa

n - viscosity of medium
a - molecular radius
Na - avogrados , constant

Question 9

The higher the D on the Stokes own Einstein equation the …

Answer 9

Faster a molecule can diffuse

Question 10

Noyes Whitney equation

Answer 10

Dm/dt = Da ( Cs - c / h )

Question 11

Osmotic pressure is directly proportional to …

Answer 11

Number of moles in solution