W1 - INTRO AND HISTORY OF MICROBIOLOGY Flashcards
cause disease when the hosts defenses are compromised or when they grow in a part of the body that is not natural to them
opportunistic pathogens
year and name
- coined “cell”
- observed cork through a microscope
1665, Robert Hooke
first to observe live microorganisms (animalcules)
anton van leeuwenhoek
leeuwenhoke made detaile ddrawings of organisms he found in the -, -, -?
rain water, feces, material scraped from teeth
devised two-part naming system; father of taxonomy
carolus linnaeus
explain abiogenesis
living organisms arise from nonliving matter
explain biogenesis
origin of life is due to pre-existing life
developers of cell theory
rudolf virchow
theodor schwann
matthias jacob schleiden
proposed theory of biogenesis; observed that cell divide to produce more cells
rudolf virchow
cell theory (3)
all living things are COMPOSED OF CELL
all life functions of an organism OCCUR WITHIN A CELL
all cells come from PRE-EXISTING CELLS
people who proved biogenesis theory
louis pasteur
francesco redi
lazzaro spallanzani
performed test for spontaneous generation (proved that cells can only arsis from pre existing cells)
louis pasteur 1864
golden age of microbiology
1857-1914
microbes is responsible for
fermentation snd spoilage of food
chemical break down of substance by bacteria, yeast and other org. - involving effervescent in the giving of heat
fermentation
produced when bacteria ferments ETHANOL in WINE
vinegar (HAc)
process if heating the object - make it safe ex milk
pasteurization
based on the concept that many diseases are caused by infections w microorganisms
germ theory of disease
laid the notion that diseases could be spread by seed-like entities and were categorized based on how they could be transmitted
Girolamo Fracastoro (1550s)
demonstrated that the disease AFFLICTING SILKWORMS was caused by a parasitic fungus
Agostino Bassi (1835)
theorized that disease in humans and animals was also caused by microorganisms
Agostino Bassi (1835)
demonstrated that life did not arrive spontaneously from non living matter
Louis Paster 1865
discovered silkworm disease was caused by a protozoan
Louis Pasteur 1865
advocated HANDWASHING to prevent the spread of puerperal fever
Ignaz Semmelweis (1840s)
used ANTISEPTICS to prevent surgical wound infections
Joseph Lister 1860s
Lister performed surgery under aseptic conditions using -
phenol
established experimental steps directly linking a specific microbe to a specific disease
Robert Koch
important diseases established by koch
Vibrio choleriae
Mycobacterium tuberculosis
Bacillus anthracis
Koch’s Postulates
- Microorganism must be found in diseased but not in healthy individuals
- Microorganism must be cultured from the disease
- Inoculation of healthy individual w the a cultured microorganism must recapitulate the disease
- Microorganism must be isolated from the inoculated
founder of vaccinology
edward jenner 1796
first smallpox wax was developed
1798
smallpox global eradication
1979
powerful chemicals to kill growing cells in body
chemotherapy
treatment for malaria
quinine
Ehrlich develioed an arsenic compound known as
Salvarsan or 606
imaginative thinker who first fired the first shot in chemotherapy revolution
Paul Ehrlich
discovered penicillin (1st antibiotic)
Alexander Fleming 1928
old name if penicillin
Penicillium notatum
new name of penicillin
Penicillium chrysogenum
in 1930s - were synthesized
Sulfonamides
when was Penicillin tested clinically and mass produced?
1940s
introduced Recombinant DNA or Hybrid DNA
Paul Berg 1960s
studies the mechanism by which the microorganism inherit traits in molecular biology
microbial genetics
bacteria once classified as plants
flora, microflora
harmless bacteria; may be beneficial; prevent growth of pathogens; produce growth factors
normal microbiota
ability to ward off disease factors
resistance
when a pathogen overcomes the hosts resistance, disease results
infectious diseases
diseases that are new or changing and are increasing or have the potential to increase in incidence in the near future
emerging infectious diseases
viral infection caused by SARS Cov
Severe Acute Respiratory Syndrome (SARS)
H1N1 influenza is also known as
swine flu
occurs in birds worldwide
Avian Influenza (H5N1) or bird flu
in 2013, - sickened 132 people in China
H7N9